Open letter to the Lancet

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On 13 November 2015, an open letter to the medical journal,The Lancet, was directed at its editor, Dr. Richard Horton, by six experts in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, calling for the PACE trial data to be independently reanalysed.[1]The Lancet published an article in on the PACE trial in 2011, Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomized trial, in which claims made by the trial authors have since been shown to be in error after being sued to release the study's raw data.[2][3]

Following a lack of response, the open letter was submitted again three months later, this time with 42 signatories.[4] A third letter was sent 10 June 2018 and had 94 signatories.[5] The third letter was resent on July 9th, 2018 and had additional signatories which included Members of Parliament, the Countess of Mar, and patient advocacy organizations.[6]

Letters[edit | edit source]

Signatories[edit | edit source]

First letter[edit | edit source]

The first letter had 6 signatures:

Second letter[edit | edit source]

The second letter had 42 signatures:

Third letter[edit | edit source]

The third letter had over one hundred signatures:[7]

Leading experts:[edit | edit source]

Members of Parliament[edit | edit source]

Patient/Advocacy Organizations[edit | edit source]

  • American ME and CFS Society, US
  • Bury and Bolton ME/CFS & Fibromyalgia Support Group, UK
  • Chester MESH (ME self-help) group, Chester, UK
  • Dr Sarah Myhill’s MAIMES [Medical Abuse In ME Sufferers] Campaign, UK
  • Group ME – The Hague/Dutch Citizens’ Initiative Recognize ME, The Netherlands
  • ME Advocates Ireland, Ireland
  • ME Victoria, Canada
  • ME/CFS and Lyme Association of WA, Inc., Australia
  • ME/CFS Australia (SA), Inc., Australia
  • ME/CVS Stichting Nederland, Netherlands
  • ME/CVS Vereniging, Netherlands
  • ME/FM Myalgic Encephalomyelitis and Fibromyalgia Society of British Columbia, Canada
  • Minnesota ME/CFS Alliance, US
  • Norfolk & Suffolk ME Patient/Carer Group, UK
  • North London ME Network, UK
  • Nottingham ME Support Group, UK
  • OMEGA (Oxfordshire ME Group for Action), UK
  • Research ME-CFS.CZ, Czech Republic
  • Sheffield ME and Fibromyalgia Group, UK
  • Steungroep ME en Arbeidsongeschiktheid, The Netherlands
  • WAMES (Welsh Association of ME & CFS Support), Wales, UK

Response[edit | edit source]

There has not been a direct response to the letter from Richard Horton or The Lancet.

See also[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Tuller, David (Nov 13, 2015). "An open letter to Dr. Richard Horton and The Lancet". www.virology.ws. Retrieved Aug 29, 2018. 
  2. sasusa (Mar 21, 2016). "PACE: The research that sparked a patient rebellion and challenged medicine - Sense About Science USA". Sense About Science USA. Retrieved Aug 29, 2018. 
  3. Wilshire, C; Kindlon, T; Matthees, A; McGrath, S (2017), "Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial", Fatigue: Biomedicine, Health & Behavior, 5 (1): 43-56, doi:10.1080/21641846.2017.1259724 
  4. 4.04.1 Tuller, David (Feb 10, 2016). "An open letter to The Lancet, again". www.virology.ws. Retrieved Aug 29, 2018. 
  5. 5.05.1 Tuller, David (Jun 19, 2018). "Trial By Error: An Open Letter to The Lancet, Two Years On". www.virology.ws. Retrieved Aug 29, 2018. 
  6. 6.06.1 Tuller, David (Jul 10, 2018). "Trial By Error: Yet Another Appeal to The Lancet, With More On Board". www.virology.ws. Retrieved Aug 29, 2018. 
  7. "Trial By Error: Open Letter to The Lancet, version 3.0". www.virology.ws. Retrieved Jan 3, 2019. 

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation

Myalgic encephalomyelitis or chronic fatigue syndrome


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history