Marcie Zinn

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Marcie Lynn Zinn Ph.D. (May 6, 1951- Dec 28, 2019) was a research psychologist in Psychophysiology, Rehabilitation, Cognitive Neuroscience and Data Science conducting myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) research with her husband, Mark Zinn, at their nonprofit, the Neurocognitive Research Institute. Dr Zinn's research interests included the study of brain dysfunction in chronic disease, such as myalgic encephalomyelitis or ME. Marcie and her husband, Mark Zinn, also founded the NeuroCognitive Research Institute. Marcie Zinn passed away suddenly from sudden heart failure[1] while working to establish the NeuroCognitive Research Institute.[2]

Dr Zinn's early research and career interests were in Performance Neuroscience and Psychology, but after being diagnosed in 2009 with herpes viral encephalitis which developed into Myalgic Encephalomyelitis, her interest turned toward using her extensive qEEG and neuroscience skills for research in ME. Under the leadership of Dr. Jose Montoya, she conducted a pilot study to look at cognitive dysfunction using qEEG methods. While continuing to collaborate with Jose Montoya at Stanford, she and her husband Mark published research using brain network modeling in the study of ME brain dysfunction.

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Marcie Zinn was a member of the Pain Working Group and the Neurologic/Cognitive/CNS Imaging Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[3]

Advocacy[edit | edit source]

Notable studies[edit | edit source]

  • June, 2004: Development of a Self-Report Inventory to Assess Cognitive Dysfunction in Musicians. ProQuest Information and Learning Company, Ann Arbor, Michigan.
  • March, 2005: The Hippocampus in Music Learning and Performance (March, 2005). Presentation at the annual Brain Awareness Week event sponsored by Dana Alliance for Brain Initiatives, Dublin, CA.
  • Mar 2014, Cortical hypoactivation during resting eLORETA suggests central nervous system pathology in patients with chronic fatigue syndrome (Conference paper, 2014 Stanford Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Symposium: Advances in Clinical Care and Translational Research for health care providers, Stanford School of Medicine, Palo Alto, CA[6] - (Abstract - full text on request)
  • Mar 2014,  EEG peak alpha frequency is associated with chronic fatigue syndrome: a case-control observational study. Invited presentation at the 2014 Stanford Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symposium : Advances in Clinical Care and Translational Research; March 19, 2014, Stanford University Dept. of Medicine, Palo Alto, CA.   
  • 2015, Myalgic Encephalomyelitis: Symptoms and Biomarkers[7] - (Full Text)
  • 2015,  Zinn, M.L. & Zinn, M.A. Psychophysiology for Performing Artists. In M. S. Schwartz & F. Andrasik, Eds: Biofeedback: A Practitioners Guide (4th ed.), New York: Guilford.
  • 2016, Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study[8] - (Full Text)
  • 2016, qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report[9] - (Full Text)
  • 2016, Functional Neural Network Connectivity in Myalgic Encephalomyelitis[10] - (Full Text)
  • 2017, Small-world network analysis of cortical connectivity in Chronic Fatigue Syndrome using quantitative EEG[11] - (Full Text)
  • 2018, Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome[12] - (Abstract)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Dr. Marcie Zinn, Ph.D. | Kaminski Family". www.kaminskifamilyfuneralhomes.com. Retrieved Jan 10, 2020. 
  2. "Click here to support Marcie Zinn Memorial Fund organized by Mark Zinn, Ph.D." gofundme.com. Retrieved Jan 9, 2020. 
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019. 
  4. "An open letter to The Lancet, again". www.virology.ws. Retrieved Dec 3, 2019. 
  5. "Trial By Error: An Open Letter to The Lancet, Two Years On". www.virology.ws. Retrieved Dec 3, 2019. 
  6. Zinn, Mark; Zinn, Marcie; Maldonado, Jose R; Norris, Jane L; Valencia, Ian J.; Montoya, Jose G (Mar 18, 2014). "Cortical hypoactivation during resting eLORETA suggests central nervous system pathology in patients with chronic fatigue syndrome". 2014 Stanford Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Symposium Conference Paper. Retrieved Dec 3, 2019. 
  7. Jason, Leonard A.; Zinn, Marcie L.; Zinn, Mark A. (Aug 31, 2015). "Myalgic Encephalomyelitis: Symptoms and Biomarkers". Current Neuropharmacology. doi:10.2174/1570159x13666150928105725. PMC 4761639Freely accessible. PMID 26411464. Retrieved Dec 3, 2019. 
  8. Zinn, Marcie L.; Zinn, Mark A.; Jason, Leonard A. (Sep 2016). "Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study". Applied Psychophysiology and Biofeedback. 41 (3): 283–300. doi:10.1007/s10484-016-9331-3. ISSN 1090-0586. 
  9. Marcie L, Zinn; Zinn, Mark A; Jason, Leonard A (2016). "qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report". Clinical Research: Open Access ( ISSN 2469-6714 ). 2 (1). doi:10.16966/2469-6714.110. 
  10. Zinn, Marcie; Zinn, Mark; Jason, Leonard (Mar 9, 2016). "Functional Neural Network Connectivity in Myalgic Encephalomyelitis". NeuroRegulation. 3 (1): 28–50. doi:10.15540/nr.3.1.28. 
  11. Zinn, Mark Alan; Zinn, Marcie L.; Jason, Leonard A. (Dec 7, 2017). "Small-World Network Analysis of Cortical Connectivity in Chronic Fatigue Syndrome Using Quantitative EEG". NeuroRegulation. 4 (3-4): 125. doi:10.15540/nr.4.3-4.125. ISSN 2373-0587. 
  12. Zinn, M.A.; Zinn, M.L.; Valencia, I.; Jason, L.A.; Montoya, J.G. (Jul 2018). "Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome". Biological Psychology. 136: 87–99. doi:10.1016/j.biopsycho.2018.05.016. PMID 29802861. 

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

chronic disease - a disease or condition that usually lasts for 3 months or longer and may get worse over time

cognition - Thought processes, including attention, reasoning, and memory.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.