Maureen Hanson

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Source:Cornell.edu

Maureen R. Hanson, PhD., is the Liberty Hyde Bailey Professor in the Department of Molecular Biology & Genetics, Cornell University, Ithaca, New York, US. In addition to her research on genome-containing organelles of plants, chloroplasts and mitochondria, she is exploring the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Research goals include examining the gut and blood microbiome in healthy vs. ill subjects and identifying differences in gene expression before and after exercise in subjects diagnosed with CFS/ME compared to healthy subjects.[1]

Dr. Hanson, together with a team of researchers and clinicians at Ithaca College collaborated to create a new ME/CFS research center called the Center for Enervating NeuroImmune Disease (CENID).[2] She, also, is a member of the Working Group which offers their expertise and resources to the ME/CFS Collaborative Research Center at Stanford University.[3]

Dr. Hanson's strong desire to research and advocate for ME/CFS is motivated by her having a family member with chronic fatigue syndrome.[4]

Education[edit | edit source]

  • B.S. degree at Duke University
  • Ph.D. in Cell and Developmental Biology from Harvard University
  • NIH postdoctoral fellowship at Harvard

Cornell ME/CFS Collaborative Research Center[edit | edit source]

In 2017, Maureen Hanson, Ph.D. was named the Principal Investigator of the Cornell ME/CFS Collaborative Research Center, a collaborative research center partly funded by an NIH grant.[5]

Committees and boards[edit | edit source]

IOM Committee on Diagnostic Criteria for ME/CFS[edit | edit source]

Dr Hanson was a reviewer for the 2015 report produced by the Institute of Medicine's Committee on Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[6]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Biomarkers Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[7]

Notable studies[edit | edit source]

2020, Letter to the Editor of Metabolites[17] - (Full letter)
  • 2020, Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations[18] - (Full text)
  • 2020, Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: A pilot study[19] - (Full text)

Talks and interviews[edit | edit source]

Articles[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Maureen Hanson | Department of Molecular Biology and Genetics". mbg.cornell.edu. Retrieved Aug 26, 2019. 
  2. Webinar with Dr. Maureen Hanson, retrieved Aug 26, 2019 
  3. "OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University". bos.etapestry.com. Retrieved Aug 26, 2019. 
  4. "Hanson's Metabolomics ME/CFS Study Validates Naviaux's Core Finding". Health Rising's Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Forums. Retrieved Aug 26, 2019. 
  5. "NIH announces centers for myalgic encephalomyelitis/chronic fatigue syndrome research". NIH. Jan 2, 2019. 
  6. https://www.nap.edu/resource/19012/MECFS_Powerpoint.pdf
  7. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019. 
  8. Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M.; Ruscetti, Francis W.; Lo, Shyh-Ching; Klimas, Nancy; Komaroff, Anthony L.; Montoya, Jose G.; Bateman, Lucinda; Levine, Susan; Peterson, Daniel; Levin, Bruce; Hanson, Maureen R.; Genfi, Afia; Bhat, Meera; Zheng, HaoQiang; Wang, Richard; Li, Bingjie; Hung, Guo-Chiuan; Lee, Li Ling; Sameroff, Stephen; Heneine, Walid; Coffin, John; Hornig, Mady; Lipkin, W. Ian (2012), "A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus", mBio, 3 (5): e00266–12, doi:10.1128/mBio.00266-12 
  9. Giloteaux, Ludovic; Hanson, Maureen R.; Keller, Betsy (2016), "A Pair of Identical Twins Discordant for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Differ in Physiological Parameters and Gut Microbiome Composition", American Journal of Case Reports, 17: 720-729, doi:10.12659/AJCR.900314 
  10. Giloteaux, L.; Goodrich, J. K.; Walters, W. A.; Levine, S. M.; Ley, R.; Hanson, M. R. (2016), "Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome.", Microbiome, 4 (1): 30, doi:10.1186/s40168-016-0171-4, PMID 27338587 
  11. Billing-Ross, Paul; Germain, Arnaud; Ye, Kaixiong; Keinan, Alon; Gu, Zhenglong; Hanson, Maureen R. (Dec 2016). "Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome". Journal of Translational Medicine. 14 (1). doi:10.1186/s12967-016-0771-6. ISSN 1479-5876. PMC 4719218Freely accessible. PMID 26791940. 
  12. Hanson, Maureen R.; Gu, Zhenglong; Keinan, Alon; Ye, Kaixiong; Germain, Arnaud; Billing-Ross, Paul (Dec 20, 2016). "Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms". Journal of Translational Medicine. 14 (1): 342. doi:10.1186/s12967-016-1104-5. ISSN 1479-5876. PMC 5175376Freely accessible. PMID 27998272. 
  13. Germain, Arnaud; Ruppert, David; Levine, Susan M.; Hanson, Maureen R. (2017), "Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism", Molecular BioSystems, 2017 (2), doi:10.1039/C6MB00600K 
  14. Mandarano, AH; Giloteaux, L; Keller, BA; Levine, SM; Hanson, MR (2018), "Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome", PeerJ, 6: e4282, doi:10.7717/peerj.4282 
  15. Germain, Arnaud; Ruppert, David; Levine, Susan M.; Hanson, Maureen R. (Dec 2018). "Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology". Metabolites. 8 (4): 90. doi:10.3390/metabo8040090. 
  16. Germain, Arnaud; Barupal, Dinesh K.; Levine, Susan M.; Hanson, Maureen R. (Jan 14, 2020). "Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids". Metabolites. 10 (1): 34. doi:10.3390/metabo10010034. ISSN 2218-1989. 
  17. Hanson, Maureen R.; Germain, Arnaud (May 25, 2020). "Letter to the Editor of Metabolites". Metabolites. 10 (5): 216. doi:10.3390/metabo10050216. ISSN 2218-1989. 
  18. Mandarano, Alexandra H.; Maya, Jessica; Giloteaux, Ludovic; Peterson, Daniel L.; Maynard, Marco; Gottschalk, C. Gunnar; Hanson, Maureen R.; Maureen Hanson (Feb 10, 2020). "Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations". Journal of Clinical Investigation. 130 (3): 1491–1505. doi:10.1172/jci132185. 
  19. Giloteaux, Ludovic; O’Neal, Adam; Castro-Marrero, Jesús; Levine, Susan M.; Hanson, Maureen R. (Dec 2020). "Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study". Journal of Translational Medicine. 18 (1): 387. doi:10.1186/s12967-020-02560-0. ISSN 1479-5876. PMC 7552484Freely accessible. 
  20. "Invest in ME Research - International ME Conferences and Colloquiums Home Page". investinme.org. Retrieved Aug 26, 2019. 
  21. "ME/CFS Canadian Collaborative Team Conference program" (PDF). Retrieved Mar 6, 2019. 
  22. "Invest in ME Research - IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019". www.investinme.org. Retrieved Feb 26, 2020. 

genome - an organism’s complete set of DNA, including all of its genes

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

eukaryote - any cell or organism that possesses a clearly defined nucleus, unlike bacteria. Eukaryotes include yeast, fungus, plants, and animals.

metabolomics - The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

metabolite - A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

T cell - A type of white blood cell which is mostly produced or matured in the thymus gland (hence T-cell) and is involved in the adaptive immune response on a cellular level. Also known as a T lymphocyte. (Learn more: www.youtube.com)

extracellular vesicle - An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

microbiome - The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

microbiome - The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.