Alexandra Mandarano

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Alexandra H. Mandarano is a Ph.D. student in the Hanson lab at Cornell University, supervised by Dr. Maureen Hanson.[1]

Notable studies[edit | edit source]

  • 2018, Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome[2] - (Full text)
  • 2020, Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations[3] - (Full text)

See also[edit | edit source]

References[edit | edit source]

  1. ↑ "SMCI's Research Advisory Board member, Dr. Maureen Hanson, publishes new study". Solve ME/CFS Initiative. February 22, 2018. Retrieved April 5, 2019.
  2. ↑ Mandarano, AH; Giloteaux, L; Keller, BA; Levine, SM; Hanson, MR (2018), "Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome", PeerJ, 6: e4282, doi:10.7717/peerj.4282
  3. ↑ Mandarano, Alexandra H.; Maya, Jessica; Giloteaux, Ludovic; Peterson, Daniel L.; Maynard, Marco; Gottschalk, C. Gunnar; Hanson, Maureen R. (March 2, 2020). "Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations". The Journal of Clinical Investigation. 130 (3): 1491–1505. doi:10.1172/JCI132185. ISSN 1558-8238. PMC 7269566. PMID 31830003.

eukaryote any cell or organism that possesses a clearly defined nucleus, unlike bacteria. Eukaryotes include yeast, fungus, plants, and animals.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

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