Anthony Komaroff

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Source:bwh.harvard.edu

Anthony L. Komaroff, MD, is an Internal Medicine physician and a foremost expert in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) since the late 1980s. As of 1993, he has been a professor at Harvard Medical School in the United States, holding the title of the Steven P. Simcox, Patrick A. Clifford and James H. Higby Distinguished Professor of Medicine.[1][2]

Dr. Komaroff serves on the team for the Center for Solutions for ME/CFS at Columbia University, a Collaborative Research Center (CRC) partially funded by the National Institutes of Health (NIH).[3]

He was quoted in a Rolling Stone article in 1987, written by Hillary Johnson, stating that he did not agree the illness was a "yuppie disease", which became the derogatory label commonly used later, "Yuppie Flu".[4] He is featured in Ryan Prior's documentary, Forgotten Plague.

Committees and Boards[edit | edit source]

Education[edit | edit source]

  • 1959 – 1963, A.B., History, Pre-Med, Stanford University
  • 1963 – 1967, M.D., University of Washington

Awards and Honors[edit | edit source]

  • 2001, Rudy Perpich Senior Lectureship Award, presented to a distinguished CFS/FM scientist, physician or healthcare worker awarded by IACFS/ME[9]
  • Fellow of the American Association for the Advancement of Science, the American College of Physicians, and the Association for Health Services Research.
  • Served on advisory committees for the U.S. Department of Health and Human Services, (HHS) the Surgeon General of the United States, the Centers for Disease Control and Prevention (CDC), and the Institute of Medicine/National Academy of Sciences.
  • Member of the Scientific Advisory Board of the HHV-6 Foundation.[10]

Medscape Continuing Medicine Education[edit | edit source]

Articles[edit | edit source]

Research articles[edit | edit source]

Talks and interviews[edit | edit source]

  • Topic: "ME/CFS: The Mysterious Illness Science Has Yet to Unravel"[42][43]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Anthony Komaroff | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved Jul 8, 2018. 
  2. "Anthony L. Komaroff". LinkedIn. 
  3. "NIH Awards $9.6 Million Grant to Columbia for a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center | Columbia University Mailman School of Public Health". www.mailman.columbia.edu. Retrieved Aug 7, 2018. 
  4. Johnson, Hillary (Aug 13, 1987). "Journey Into Fear: Part Two". Rolling Stone. Retrieved Aug 14, 2018. 
  5. "Committees of the IACFS/ME". iacfsme.org. 
  6. HHS.gov (2006), Nov 20 & 21, 2006 CFSAC Meeting (PDF) (Minutes) 
  7. "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Elements (CDE) Working Group Roster". www.commondataelements.ninds.nih.gov. Retrieved Aug 7, 2018. 
  8. "NINDS CDE Project Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Baseline/Covariate Information Subgroup" (PDF). commondataelements.ninds.nih.gov. 
  9. "Former IACFS/ME Awardees". iacfsme.org. 
  10. "Scientific Advisory Board | HHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a Grant". hhv-6foundation.org. Retrieved Aug 7, 2018. 
  11. Corbin, Lisa; Komaroff, Anthony L.; Natelson Peter C. Rowe, Benjamin H.; Rowe, Peter. "A Case-Based Approach to Chronic Fatigue Syndrome". Medscape. Retrieved Oct 11, 2019. 
  12. Komoroff, Anthony L. "NEJM Journal Watch: Summaries of and commentary on original medical and scientific articles from key medical journals". www.jwatch.org. Retrieved Aug 14, 2018. 
  13. Komaroff, Anthony L. (Jun 16, 2015). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Real Illness". Annals of Internal Medicine. 162 (12): 871. doi:10.7326/m15-0647. ISSN 0003-4819. 
  14. Komaroff, Anthony L. (Jul 5, 2019). "Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome". JAMA. doi:10.1001/jama.2019.8312. 
  15. MD, Anthony Komaroff (Nov 14, 2019). "Chronic fatigue syndrome: Gradually figuring out what's wrong". Harvard Health Blog. Retrieved Nov 19, 2019. 
  16. Buchwald, Dedra; Cheney, Paul R.; Peterson, Daniel L.; Henry, Berch; Wormsley, Susan B.; Geiger, Ann; Ablashi, Dharam V.; Salahuddin, S. Zaki; Saxinger, Carl; Biddle, Royce; Kikinis, Ron; Jolesz, Ferenc A.; Folks, Thomas; Balachandran, N.; Peter, James B.; Gallo, Robert C.; Komaroff, Anthony L. (1992), "A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection", Annals of Internal Medicine, 116 (2): 103-113, PMID 1309285 
  17. Ablashi, DV; Berneman, ZN; Williams, M; Strayer, D; Kramarsky, B; Suhadolnik, RJ; Reichenbach, N; Hiltzges, P; Komaroff, AL (1994), "Ampligen inhibits human herpesvirus-6 in vitro", In Vivo, 8 (4): 587-91, PMID 7893986 
  18. Fukuda, Keiji; Straus, Stephen E; Sharpe, Michael C.; Dobbins, James G.; Komaroff, Anthony; International Chronic Fatigue Syndrome Study Group (Dec 15, 1994). "The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study". Annals of Internal Medicine. 121 (12): 953. doi:10.7326/0003-4819-121-12-199412150-00009. ISSN 0003-4819. 
  19. Evengård, B.; Schacterle, R. S.; Komaroff, A. L. (Nov 1999). "Chronic fatigue syndrome: new insights and old ignorance". Journal of Internal Medicine. 246 (5): 455–469. ISSN 0954-6820. PMID 10583715. 
  20. Schacterle, Richard S.; Conti, Fabrizio; Magrini, Laura; Komaroff, Anthony; Valesini, Guido (Dec 4, 2001). "Increased Eosinophil Protein X Levels in Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome. 9: 21–30. doi:10.1300/J092v09n01_03. 
  21. Matthews, Rosalind M.; Komaroff, Anthony L. (Jan 2007). "Changes in Functional Status in Chronic Fatigue Syndrome Over a Decade". Journal of Chronic Fatigue Syndrome. 14 (1): 33–42. doi:10.1300/j092v14n01_04. ISSN 1057-3321. 
  22. Kerr, J. R.; Gough, J.; Richards, S. C. M.; Main, J.; Enlander, D.; McCreary, M.; Komaroff, A. L.; Chia, J. K. (Apr 1, 2010). "Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis". Journal of General Virology. 91 (4): 893–897. doi:10.1099/vir.0.017590-0. ISSN 0022-1317. 
  23. Simmons, Graham; Glynn, Simone A.; Komaroff, Anthony L.; Mikovits, Judy A.; Tobler, Leslie H.; Hackett, John; Tang, Ning; Switzer, William M.; Heneine, Walid (Nov 11, 2011). "Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study". Science. 334 (6057): 814–817. doi:10.1126/science.1213841. ISSN 0036-8075. PMC 3299483Freely accessible. PMID 21940862. 
  24. Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M.; Ruscetti, Francis W.; Lo, Shyh-Ching; Klimas, Nancy; Komaroff, Anthony L.; Montoya, Jose G.; Bateman, Lucinda; Levine, Susan; Peterson, Daniel; Levin, Bruce; Hanson, Maureen R.; Genfi, Afia; Bhat, Meera; Zheng, HaoQiang; Wang, Richard; Li, Bingjie; Hung, Guo-Chiuan; Lee, Li Ling; Sameroff, Stephen; Heneine, Walid; Coffin, John; Hornig, Mady; Lipkin, W. Ian (2012), "A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus", mBio, 3 (5): e00266–12, doi:10.1128/mBio.00266-12 
  25. Klimas, N.G.; Ironson, G.; Carter, A.; Balbin, E.; Bateman, L.; Felsenstein, D.; Levine, S.; Peterson, D.; Chiu, K.; Allen, A.; Cunningham, K.; Gottschalk, C.G.; Fletcher, M; Hornig, M.; Canning, C.; Komaroff, A.L. (2015), "Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, 3 (2): 75-96, doi:10.1080/21641846.2015.1023652 
  26. Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015). "Distinct plasma immune signatures in ME/CFS are present early in the course of illness". Science Advances. 1 (1). doi:10.1126/sciadv.1400121. 
  27. Unger, ER; Lin, JS; Brimmer, DJ; Lapp, CW; Komaroff, AL; Nath, A; Laird, S; Iskander, J (2016). "CDC Grand Rounds: Chronic Fatigue Syndrome — Advancing Research and Clinical Education". Morbidity and Mortality Weekly Report. 65 (5051): 1434–1438. doi:10.15585/mmwr.mm655051a4.  -
  28. Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y 
  29. Komaroff, A.L. (2017), "Inflammation correlates with symptoms in chronic fatigue syndrome", PNAS, Proceedings of the National Academy of Sciences, 114 (34): 8914–8916, doi:10.1073/pnas.1712475114 
  30. Komaroff, AL; Takahashi, R; Yamamura, T; Sawamura, M (2018), "Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review", Brain Nerve, 70 (1): 41-54, doi:10.11477/mf.1416200948, PMID 29348374 
  31. Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J. R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9 
  32. King, Llewellyn (Apr 25, 2014). "MECFS Alert Episode 60: Interview with Dr. Anthony Komaroff, Harvard Medical School". YouTube. ME/CFS Alert. 
  33. King, Llewellyn (May 22, 2014). "MECFS Alert Episode 61: Dr. Anthony Komaroff, Part 2". YouTube. ME/CFS Alert. 
  34. King, Llewelyn (Jun 3, 2014). "MECFS Alert Episode 62: Dr. Anthony Komaroff, Part 3". YouTube. ME/CFS Alert. 
  35. King, Llewellyn (Jun 14, 2015). "Episode 63: Dr. Anthony Komaroff Offers Advice for the Department of Health". YouTube. ME/CFS Alert. 
  36. Iskander, John (Feb 17, 2016). "Beyond the Data – Chronic Fatigue Syndrome: Advancing Research and Clinical Education". Youtube. Centers for Disease Control and Prevention (CDC). 
  37. Lapp, Charles; Unger, Elizabeth; Komaroff, Anthony; Nath, Avindra (Feb 16, 2016). "Chronic Fatigue Syndrome: Advancing Research and Clinical Education". cdc.gov (Video). Centers for Disease Control and Prevention (CDC). 
  38. Lapp, Charles; Unger, Elizabeth; Komaroff, Anthony; Nath, Avindra (2016). "Chronic Fatigue Syndrome: Advancing Research and Clinical Education" (PDF). cdc.gov. Centers for Disease Control and Prevention (CDC). 
  39. Komaroff, Anthony (Fall 2016). "ME/CFS: A Surge of Interest and Knowledge (Lecture) | Anthony L. Komaroff, MD". YouTube. Massachusetts CFIDS/ME & FM Association. 
  40. Komaroff, Anthony L. (Nov 10, 2016). "Webinar with Dr. Anthony L. Komaroff". YouTube. 
  41. King, Llewellyn (Nov 18, 2016). "Dr Anthony Komaroff on ME/CFS Treatment and Research | Ep 85". YouTube. ME/CFS Alert. 
  42. "ME/Chronic Fatigue Syndrome Takes Center Stage on First Afternoon of Personalized Medicine World Conference (PMWC) 2017 at Duke | www.bioquicknews.com". www.bioquicknews.com. Jun 6, 2017. Retrieved Aug 14, 2018. 
  43. "ME/CFS: The Mysterious Illness Science Has Yet to Unravel Session Chair: Zaher Nahle, Solve ME/CFS Initiative - Precision Medicine World Conference 2017 Duke". Precision Medicine World Conference 2017 Duke. Retrieved Aug 14, 2018. 
  44. Komaroff, Anthony (May 29, 2018). ""Hot Areas in ME/CFS Research: 2018"". YouTube. SolveCFS. 
  45. "ME/CFS Advocacy Call - July 19, 2018". nih.gov. National Institutes of Health. 
  46. "ME/CFS: A Surge of Interest and Knowledge (Lecture) | Anthony L. Komaroff, MD". YouTube. MassCFIDSFM. Jan 7, 2019. 
  47. Murphy, Dylan (Apr 12, 2019). "Meet The Scientist: Professor Anthony Komaroff". #MEAction. Retrieved Apr 13, 2019. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.