Anthony Komaroff

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Source:bwh.harvard.edu

Anthony L. Komaroff, MD, is an Internal Medicine physician and a foremost expert in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) since the late 1980s. As of 1993, he has been a professor at Harvard Medical School in the United States, holding the title of the Steven P. Simcox, Patrick A. Clifford and James H. Higby Distinguished Professor of Medicine.[1][2]

Dr. Komaroff serves on the team for the Center for Solutions for ME/CFS at Columbia University, a Collaborative Research Center (CRC) partially funded by the National Institutes of Health (NIH).[3]

He was quoted in a Rolling Stone article in 1987, written by Hillary Johnson, stating that he did not agree the illness was a "yuppie disease", which became the derogatory label commonly used later, "Yuppie Flu".[4] He is featured in Ryan Prior's documentary, Forgotten Plague.

Committees and Boards[edit | edit source]

Education[edit | edit source]

  • 1959 – 1963, A.B., History, Pre-Med, Stanford University
  • 1963 – 1967, M.D., University of Washington

Awards and Honors[edit | edit source]

  • 2001, Rudy Perpich Senior Lectureship Award, presented to a distinguished CFS/FM scientist, physician or healthcare worker awarded by IACFS/ME[9]
  • Fellow of the American Association for the Advancement of Science, the American College of Physicians, and the Association for Health Services Research.
  • Served on advisory committees for the U.S. Department of Health and Human Services, (HHS) the Surgeon General of the United States, the Centers for Disease Control and Prevention (CDC), and the Institute of Medicine/National Academy of Sciences.
  • Member of the Scientific Advisory Board of the HHV-6 Foundation.[10]

Medscape Continuing Medicine Education[edit | edit source]

Articles[edit | edit source]

Research articles[edit | edit source]

  • 1992, A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection[17] - (Abstract)
  • 1994, Ampligen inhibits human herpesvirus-6 in vitro[18] -(Abstract)
  • 1994, The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group[19] - (Abstract)
  • 1999, Chronic fatigue syndrome: new insights and old ignorance[20] - (Abstract)
  • 2001, Increased Eosinophil Protein X Levels in Chronic Fatigue Syndrome[21] - (Abstract)
  • 2007, Changes in Functional Status in Chronic Fatigue Syndrome Over a Decade: Do Age and Gender Matter?[22] - (Abstract)
  • 2010, Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis[23] - (Full Text)
  • 2011, Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study[24] - (Full Text)
  • 2012, A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus[25] - (Full Text)
  • 2015, Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome[26] - (Abstract)
  • 2015, Distinct plasma immune signatures in ME/CFS are present early in the course of illness[27] - (Full text)
  • 2016, CDC Grand Rounds: Chronic Fatigue Syndrome — Advancing Research and Clinical Education. Morbidity and Mortality Weekly Report[28] - (Full Text)
  • 2017, Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome[29] - (Full Text)
  • 2017, Inflammation correlates with symptoms in chronic fatigue syndrome[30] - (Full Text)
  • 2018, Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review[31] - (Abstract)
  • 2018, Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics[32] - (Full Text)
  • 2019, Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome[33] (Abstract)
  • 2020, Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS[34] - (Full text)
  • 2020, Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation[35] (Full text)
  • 2021, Will COVID-19 lead to myalgic encephalomyelitis/chronic fatigue syndrome?[36] (Full text)
  • 2021, Insights from ME/CFS May Help Unravel the Pathogenesis of Post-Acute COVID-19 Syndrome[37] (Full text)
  • 2021, Dysregulation of the Kennedy Pathway and Tricarboxylic Acid Cycle in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[38] (Full text)

Talks and interviews[edit | edit source]

  • Topic: "ME/CFS: The Mysterious Illness Science Has Yet to Unravel"[49][50]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ "Anthony Komaroff | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved July 8, 2018.
  2. ↑ "Anthony L. Komaroff". LinkedIn.
  3. ↑ "NIH Awards $9.6 Million Grant to Columbia for a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center | Columbia University Mailman School of Public Health". mailman.columbia.edu. Retrieved August 7, 2018.
  4. ↑ Johnson, Hillary (August 13, 1987). "Journey Into Fear: Part Two". Rolling Stone. Retrieved August 14, 2018.
  5. ↑ "Committees of the IACFS/ME". IACFSME.
  6. ↑ HHS.gov (2006), Nov 20 & 21, 2006 CFSAC Meeting (PDF) (Minutes)
  7. ↑ "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Elements (CDE) Working Group Roster". commondataelements.ninds.nih.gov. Retrieved August 7, 2018.
  8. ↑ "NINDS CDE Project Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Baseline/Covariate Information Subgroup" (PDF). commondataelements.ninds.nih.gov.
  9. ↑ "IACFS/ME Awardees". IACFS/ME. Retrieved April 13, 2020.
  10. ↑ "Scientific Advisory Board | HHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a Grant". hhv-6foundation.org. Retrieved August 7, 2018.
  11. ↑ Corbin, Lisa; Komaroff, Anthony L.; Natelson Peter C. Rowe, Benjamin H.; Rowe, Peter. "A Case-Based Approach to Chronic Fatigue Syndrome". Medscape. Retrieved October 11, 2019.
  12. ↑ Komoroff, Anthony L. "NEJM Journal Watch: Summaries of and commentary on original medical and scientific articles from key medical journals". jwatch.org. Retrieved August 14, 2018.
  13. ↑ Komaroff, Anthony L. (June 16, 2015). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Real Illness". Annals of Internal Medicine. 162 (12): 871. doi:10.7326/m15-0647. ISSN 0003-4819.
  14. ↑ Komaroff, Anthony L. (July 5, 2019). "Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome". JAMA. doi:10.1001/jama.2019.8312.
  15. ↑ Komaroff, Anthony (November 14, 2019). "Chronic fatigue syndrome: Gradually figuring out what's wrong". Harvard Health Blog. Retrieved November 19, 2019.
  16. ↑ Komaroff, Anthony L. (July 20, 2021). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied". Healthcare. 9 (7): 919. doi:10.3390/healthcare9070919. ISSN 2227-9032. PMC 8307552. PMID 34356297.
  17. ↑ Buchwald, Dedra; Cheney, Paul R.; Peterson, Daniel L.; Henry, Berch; Wormsley, Susan B.; Geiger, Ann; Ablashi, Dharam V.; Salahuddin, S. Zaki; Saxinger, Carl; Biddle, Royce; Kikinis, Ron; Jolesz, Ferenc A.; Folks, Thomas; Balachandran, N.; Peter, James B.; Gallo, Robert C.; Komaroff, Anthony L. (1992), "A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection", Annals of Internal Medicine, 116 (2): 103–113, PMID 1309285
  18. ↑ Ablashi, DV; Berneman, ZN; Williams, M; Strayer, D; Kramarsky, B; Suhadolnik, RJ; Reichenbach, N; Hiltzges, P; Komaroff, AL (1994), "Ampligen inhibits human herpesvirus-6 in vitro", In Vivo, 8 (4): 587-91, PMID 7893986
  19. ↑ Fukuda, Keiji; Straus, Stephen E; Sharpe, Michael C.; Dobbins, James G.; Komaroff, Anthony; International Chronic Fatigue Syndrome Study Group (December 15, 1994). "The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study". Annals of Internal Medicine. 121 (12): 953. doi:10.7326/0003-4819-121-12-199412150-00009. ISSN 0003-4819.
  20. ↑ Evengård, B.; Schacterle, R.S.; Komaroff, A.L. (November 1999). "Chronic fatigue syndrome: new insights and old ignorance". Journal of Internal Medicine. 246 (5): 455–469. ISSN 0954-6820. PMID 10583715.
  21. ↑ Schacterle, Richard S.; Conti, Fabrizio; Magrini, Laura; Komaroff, Anthony; Valesini, Guido (December 4, 2001). "Increased Eosinophil Protein X Levels in Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome. 9: 21–30. doi:10.1300/J092v09n01_03.
  22. ↑ Matthews, Rosalind M.; Komaroff, Anthony L. (January 2007). "Changes in Functional Status in Chronic Fatigue Syndrome Over a Decade". Journal of Chronic Fatigue Syndrome. 14 (1): 33–42. doi:10.1300/j092v14n01_04. ISSN 1057-3321.
  23. ↑ Kerr, J.R.; Gough, J.; Richards, S.C.M.; Main, J.; Enlander, D.; McCreary, M.; Komaroff, A.L.; Chia, J.K. (April 1, 2010). "Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis". Journal of General Virology. 91 (4): 893–897. doi:10.1099/vir.0.017590-0. ISSN 0022-1317.
  24. ↑ Simmons, Graham; Glynn, Simone A.; Komaroff, Anthony L.; Mikovits, Judy A.; Tobler, Leslie H.; Hackett, John; Tang, Ning; Switzer, William M.; Heneine, Walid (November 11, 2011). "Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-Laboratory Study". Science. 334 (6057): 814–817. doi:10.1126/science.1213841. ISSN 0036-8075. PMC 3299483. PMID 21940862.
  25. ↑ Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M.; Ruscetti, Francis W.; Lo, Shyh-Ching; Klimas, Nancy; Komaroff, Anthony L.; Montoya, Jose G.; Bateman, Lucinda; Levine, Susan; Peterson, Daniel; Levin, Bruce; Hanson, Maureen R.; Genfi, Afia; Bhat, Meera; Zheng, HaoQiang; Wang, Richard; Li, Bingjie; Hung, Guo-Chiuan; Lee, Li Ling; Sameroff, Stephen; Heneine, Walid; Coffin, John; Hornig, Mady; Lipkin, W. Ian (2012), "A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus", mBio, 3 (5): e00266–12, doi:10.1128/mBio.00266-12
  26. ↑ Klimas, N.G.; Ironson, G.; Carter, A.; Balbin, E.; Bateman, L.; Felsenstein, D.; Levine, S.; Peterson, D.; Chiu, K.; Allen, A.; Cunningham, K.; Gottschalk, C.G.; Fletcher, M; Hornig, M.; Canning, C.; Komaroff, A.L. (2015), "Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, 3 (2): 75-96, doi:10.1080/21641846.2015.1023652
  27. ↑ Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015). "Distinct plasma immune signatures in ME/CFS are present early in the course of illness". Science Advances. 1 (1): e1400121. doi:10.1126/sciadv.1400121.
  28. ↑ Unger, ER; Lin, JS; Brimmer, DJ; Lapp, CW; Komaroff, AL; Nath, A; Laird, S; Iskander, J (2016). "CDC Grand Rounds: Chronic Fatigue Syndrome — Advancing Research and Clinical Education". Morbidity and Mortality Weekly Report. 65 (5051): 1434–1438. doi:10.15585/mmwr.mm655051a4.
  29. ↑ Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y
  30. ↑ Komaroff, A.L. (2017), "Inflammation correlates with symptoms in chronic fatigue syndrome", PNAS, Proceedings of the National Academy of Sciences, 114 (34): 8914–8916, doi:10.1073/pnas.1712475114
  31. ↑ Komaroff, AL; Takahashi, R; Yamamura, T; Sawamura, M (2018), "Neurologic Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review", Brain Nerve, 70 (1): 41-54, doi:10.11477/mf.1416200948, PMID 29348374
  32. ↑ Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J.R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9
  33. ↑ Komaroff, Anthony L. (August 13, 2019). "Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome". JAMA. 322 (6): 499–500. doi:10.1001/jama.2019.8312. ISSN 0098-7484.
  34. ↑ Milivojevic, Milica; Che, Xiaoyu; Bateman, Lucinda; Cheng, Aaron; Garcia, Benjamin A.; Hornig, Mady; Huber, Manuel; Klimas, Nancy G.; Lee, Bohyun; Lee, Hyoungjoo; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Komaroff, Anthony; Lipkin, W. Ian (July 21, 2020). "Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS". PLOS ONE. 15 (7): e0236148. doi:10.1371/journal.pone.0236148. ISSN 1932-6203. PMC 7373296. PMID 32692761.
  35. ↑ Komaroff, Anthony L.; Pellett, Philip E.; Jacobson, Steven (2020). "Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation". Clinical Microbiology Reviews. 34 (1): e00143-20. doi:10.1128/cmr.00143-20. PMC 7667666. PMID 33177186.
  36. ↑ Komaroff, Anthony L.; Bateman, Lucinda (2021). "Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?". Frontiers in Medicine. 7: 606824. doi:10.3389/fmed.2020.606824. ISSN 2296-858X. PMC 7848220. PMID 33537329.
  37. ↑ Komaroff, Anthony L.; Lipkin, W. Ian (June 7, 2021). "Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome". Trends in Molecular Medicine. 27 (8): 895–906. doi:10.1016/j.molmed.2021.06.002. ISSN 1471-4914. PMID 34175230.
  38. ↑ Che, Xiaoyu; Brydges, Christopher R.; Yu, Yuanzhi; Price, Adam; Joshi, Shreyas; Roy, Ayan; Lee, Bohyun; Barupal, Dinesh K.; Cheng, Aaron (June 22, 2021). "Dysregulation of the Kennedy Pathway and Tricarboxylic Acid Cycle in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". medRxiv: 2021.06.14.21258895. doi:10.1101/2021.06.14.21258895.
  39. ↑ King, Llewellyn (April 25, 2014). "MECFS Alert Episode 60: Interview with Dr. Anthony Komaroff, Harvard Medical School". YouTube. ME/CFS Alert.
  40. ↑ King, Llewellyn (May 22, 2014). "MECFS Alert Episode 61: Dr. Anthony Komaroff, Part 2". YouTube. ME/CFS Alert.
  41. ↑ King, Llewelyn (June 3, 2014). "MECFS Alert Episode 62: Dr. Anthony Komaroff, Part 3". YouTube. ME/CFS Alert.
  42. ↑ King, Llewellyn (June 14, 2015). "Episode 63: Dr. Anthony Komaroff Offers Advice for the Department of Health". YouTube. ME/CFS Alert.
  43. ↑ Iskander, John (February 17, 2016). "Beyond the Data – Chronic Fatigue Syndrome: Advancing Research and Clinical Education". Youtube. Centers for Disease Control and Prevention (CDC).
  44. ↑ Lapp, Charles; Unger, Elizabeth; Komaroff, Anthony; Nath, Avindra (February 16, 2016). "Chronic Fatigue Syndrome: Advancing Research and Clinical Education". cdc.gov (Video). Centers for Disease Control and Prevention (CDC).
  45. ↑ Lapp, Charles; Unger, Elizabeth; Komaroff, Anthony; Nath, Avindra (2016). "Chronic Fatigue Syndrome: Advancing Research and Clinical Education" (PDF). cdc.gov. Centers for Disease Control and Prevention (CDC).
  46. ↑ Komaroff, Anthony (Fall 2016). "ME/CFS: A Surge of Interest and Knowledge (Lecture) | Anthony L. Komaroff, MD". YouTube. Massachusetts CFIDS/ME & FM Association.
  47. ↑ Komaroff, Anthony L. (November 10, 2016). "Webinar with Dr. Anthony L. Komaroff". YouTube.
  48. ↑ King, Llewellyn (November 18, 2016). "Dr Anthony Komaroff on ME/CFS Treatment and Research | Ep 85". YouTube. ME/CFS Alert.
  49. ↑ "ME/Chronic Fatigue Syndrome Takes Center Stage on First Afternoon of Personalized Medicine World Conference (PMWC) 2017 at Duke". bioquicknews.com. June 6, 2017. Retrieved August 14, 2018.
  50. ↑ Session Chair: Zaher Nahle, Solve ME/CFS Initiative - Precision Medicine World Conference 2017 Duke. "ME/CFS: The Mysterious Illness Science Has Yet to Unravel". Precision Medicine World Conference 2017 Duke. Retrieved August 14, 2018.
  51. ↑ Komaroff, Anthony (May 29, 2018). ""Hot Areas in ME/CFS Research: 2018"". YouTube. SolveCFS.
  52. ↑ "ME/CFS Advocacy Call - July 19, 2018". nih.gov. National Institutes of Health.
  53. ↑ "ME/CFS: A Surge of Interest and Knowledge (Lecture) | Anthony L. Komaroff, MD". YouTube. MassCFIDSFM. January 7, 2019.
  54. ↑ Murphy, Dylan (April 12, 2019). "Meet The Scientist: Professor Anthony Komaroff". #MEAction. Retrieved April 13, 2019.

See National Institutes of Health.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

See Centers for Disease Control and Prevention.

National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

plasma The liquid part of blood, lymph, or milk after removing any suspended material. Most of the time, "plasma" simply refers to blood, after all the blood cells have been removed. If you also remove the clotting factors, then the plasma is referred to as "serum".

B cell B lymphocyte, or a type of white blood cell, which is involved in the immune response by secreting antibodies to ward off infections. In mammals, they are mostly matured in the bone marrow.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) - Chronic Fatigue and Immune Dysfunction Syndrome is another term for Chronic Fatigue Syndrome, but one which emphasizes the immunological aspects of the disease. Popular in the 1990s, this term has apparently fallen into disuse.

See Chronic Fatigue and Immune Dysfunction Syndrome.

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