Mary Ann Fletcher

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Mary Ann Fletcher, Ph.D., is the first Schemel Professor for Neuro Immune Medicine at the Institute for Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, Florida, US.[1] Previously, she spent 40 years at the University of Miami Miller School of Medicine as a Professor of Medicine, Microbiology/Immunology and Psychology.[2] She holds two U.S. Patents for developing tests to determine if a person has mononucleosis.[1] Currently her research focus has been on the identification of diagnostic biomarkers in ME/CFS, Gulf War Illness and other multi-complex illnesses.

Education[edit | edit source]

  • Bachelor of Science in Microbiology from Texas Tech University
  • Master of Science in Immunology and Virology from University of Texas Medical School
  • Doctor of Philosophy in Immunochemistry from Baylor University
  • Postdoctoral research at Northwestern University in Chicago.

Committees and boards[edit | edit source]

Chronic Fatigue Syndrome Advisory Committee[edit | edit source]

Dr. Fletcher was a voting member of the Chronic Fatigue Syndrome Advisory Committee, for the U.S. Department of Health and Human Services, from June 13, 2012 to December 13, 2016.[3]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Immune Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[4]

Advocacy[edit | edit source]

Open Letter to The Lancet[edit | edit source]

Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016 and again in 2018 , Dr. Fletcher, along with colleagues in the ME/CFS field, signed the second and third letter.

Notable studies in ME/CFS[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 "Mary Ann Fletcher Joins Nova Southeastern University as Schemel Professor for Neuro Immune Medicine | NSU Newsroom". nsunews.nova.edu. Retrieved Jan 12, 2019. 
  2. http://iacfsme.org/Conferences/2014-San-Francisco/Agenda/Professional-Agenda.aspx
  3. http://www.hhs.gov/advcomcfs/roster/index.html
  4. "Report Viewer". www.commondataelements.ninds.nih.gov. Retrieved Jul 30, 2019. 
  5. Patarca, Roberto; Klimas, Nancy; Lugtendorf, S; Antoni, Michael H.; Fletcher, Mary Ann (1994), "Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression", Clinical Infectious Diseases, 18: S147-53, PMID 8148443 
  6. Lutgendorf, Susan; Klimas, Nancy; Antoni, Michael; Brickman, Andrew; Fletcher, Mary Ann (1995), "Relationships of Cognitive Difficulties to Immune Measures, Depression and Illness Burden in Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 1 (2): 23-41, doi:10.1300/J092v01n02_03 
  7. Lutgendorf, SK; Antoni, MH; Ironson, G; Fletcher, MA; Penedo, F; Baum, A; Schneiderman, N; Klimas, N (1995), "Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew", Psychosomatic Medicine, 57 (4): 310-23, PMID 7480560 
  8. Patarca, Patarca; Klimas, Nancy; Garcia, Maria N.; Walters, Michael J.; Dombroski, Derek; Pons, Hector; Fletcher, Mary Ann (1995), "Dysregulated Expression of Soluble Immune Mediator Receptors in a Subset of Patients with Chronic Fatigue Syndrome: Cross-Sectional Categorization of Patients by Immune Status", Journal of Chronic Fatigue Syndrome, 1 (1): 81-96, doi:10.1300/J092v01n01_06 
  9. Klimas, Nancy; Sandler, Dmitry; Garcia, Maria N.; Fletcher, Mary Ann (1996), "Interindividual Immune Status Variation Patterns in Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 2 (1): 13-39, doi:10.1300/J092v02n01_03 
  10. Roberto Patarca & Mary Ann Fletcher. (1998). Interleukin-6 and Disease: Two Case Reports that Point to the Usefulness of Measuring Cytokine Levels in Clinical Settings. Journal of Chronic Fatigue Syndrome, Vol. 4, Iss. 1, pp. 53-69. http://dx.doi.org/10.1300/J092v04n01_07
  11. Fletcher, Mary Ann; Maher, Kevin; Patarca-Montero, Roberto; Klimas, Nancy (2000), "Comparative Analysis of Lymphocytes in Lymph Nodes and Peripheral Blood of Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 7 (3): 65-75, doi:10.1300/J092v07n03_06 
  12. Klimas, Nancy; Patarca-Montero, Roberto; Maher, Kevin; Fletcher, Mary Ann (2000), "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance", Journal of Chronic Fatigue Syndrome, 8 (1): 39-55, doi:10.1300/J092v08n01_03 
  13. Montero, Roberto Patarca; Klimas, Nancy G.; Fletcher, Mary Ann (2000). "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance". Journal of Chronic Fatigue Syndrome. 8 (1): 3–37. doi:10.1300/J092v08n01_02. 
  14. Hurwitz, Barry E.; Brownley, Kimberly A.; Fletcher, Mary Ann; Klimas, Nancy (2000), "Chronic Fatigue Syndrome: Evidence Supporting the Hypothesis of a Behaviorally-Activated Neuromodulator of Fatigue", Journal of Chronic Fatigue Syndrome, 6 (1): 45-63, doi:10.1300/J092v06n02_06 
  15. Patarca-Montero, Roberto; Antoni, Michael; Fletcher, Mary Ann; Klimas, Nancy (2001), "Cytokine and Other Immunologic Markers in Chronic Fatigue Syndrome and Their Relation to Neuropsychological Factors", Applied Neuropsychology, 8 (1): 51-64, doi:10.1207/S15324826AN0801_7 
  16. Patarca, Patarca; Fletcher, Mary Ann (2002), "Effects of Benzalkonium Salts on G-protein-Mediated Processes and Surface Membranes: Relevance to Microbial- and Chemical-Induced Diseases", Journal of Chronic Fatigue Syndrome, 10 (2): 87-168, doi:10.1300/J092v10n03_07 
  17. Patarca, Patarca; Fletcher, Mary Ann (2002), "The Paul-Bunnell Heterophile Antibody Determinant in Epstein-Barr Virus-Associated Disease", Journal of Chronic Fatigue Syndrome, 10 (2): 51-86, doi:10.1300/J092v10n03_06 
  18. Jason, Leonard A.; Torres-Harding, Susan; Maher, Kevin; Reynolds, Nadia; Brown, Molly; Sorenson, Matthew; Donalek, Julie; Corradi, Karina; Fletcher, Mary Ann; Lu, Tony (2007), "Baseline Cortisol Levels Predict Treatment Outcomes in Chronic Fatigue Syndrome Nonpharmacologic Clinical Trial", Journal of Chronic Fatigue Syndrome, 14 (4): 39-59, doi:10.3109/10573320802092039 
  19. Torres-Harding, Susan; Sorenson, Matthew; Jason, Leonard; Maher, Kevin; Fletcher, Mary Ann; Reynolds, Nadia; Brown, Molly (2008), "The associations between basal salivary cortisol and illness symptomatology in chronic fatigue syndrome", Journal of Applied Biobehavioral Research, 2008 (13): 157-180, PMID 19701493 
  20. Torres-Harding, Susan; Sorenson, Matthew; Jason, Leonard; Maher, Kevin; Fletcher, Mary Ann (2008), "Evidence for T-helper 2 shift and association with illness parameters in chronic fatigue syndrome (CFS)", Bulletin of the IACFS/ME, 16 (3): 19–33., PMID 21234277 
  21. Fletcher, Mary Ann; Zeng, Xiao R; Barnes, Zachary; Levis, Silvina; Klimas, Nancy G (2009), "Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome", Journal of Translational Medicine, 7 (96), doi:10.1186/1479-5876-7-96 
  22. Broderick, Gordon; Fuite, Jim; Kreitz, Andrea; Vernon, Suzanne; Klimas, Nancy; Fletcher, Mary Ann (2010), "A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, 24 (7): 1209–1217, doi:10.1016/j.bbi.2010.04.012 
  23. Fletcher, Mary Ann; Rosenthal, Martin; Antoni, Michael; Ironson, Gail; Zeng, Xiao R; Barnes, Zachary; Harvey, Jeanna M; Hurwitz, Barry; Levis, Silvina; Broderick, Gordon; Klimas, Nancy G (2010), "Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome", Behavioral and Brain Functions, 6 (76), doi:10.1186/1744-9081-6-76 
  24. Porter, Nicole; Lerch, Athena; Jason, Leonard; Sorenson, Matthew; Fletcher, Mary Ann; Herrington, Joshua (2010), "A Comparison of Immune Functionality in Viral versus Non-Viral CFS Subtypes", Journal of Behavioral and Neuroscience Research, 8 (2): 1-8, PMID 24634898 
  25. Fletcher, M. A., Zeng, X. R., Maher, K., Levis, S., Hurwitz, B., Antoni, M., Broderick, G., Klimas, N. G. (2010). Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26. PLoS ONE, 5(5), e10817. http://doi.org/10.1371/journal.pone.0010817
  26. Klimas, NG; Broderick, G; Fletcher, MA (2012), "Biomarkers for chronic fatigue", Brain Behav Immun, 26 (8): 1202-10, doi:10.1016/j.bbi.2012.06.006, PMID 22732129 
  27. Broderick, Gordon; Katz, Ben Z; Fernandes, Henrique; Fletcher, Mary Ann; Klimas, Nancy; Smith, Frederick A; O'Gorman, Maurice RG; Vernon, Suzanne D; Taylor, Renee (2012), "Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue", Journal of Translational Medicine, 10 (191), doi:10.1186/1479-5876-10-191 
  28. Hall, DL; Lattie, EG; Antoni, MH; Fletcher, MA; Czaja, S; Perdomo, D; Klimas, NG (2014), "Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome", Psychoneuroendocrinology, 49: 26-31, doi:10.1016/j.psyneuen.2014.06.021, PMID 25049069 
  29. Craddock, Travis J. A.; Fritsch, Paul; Rice, Jr, Mark A.; del Rosario, Ryan M.; Miller, Diane B.; Fletcher, Mary Ann; Klimas, Nancy G.; Broderick, Gordon (2014), "A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome", PLOS One, 9 (1): e84839, doi:10.1371/journal.pone.0084839 
  30. Hall, DL; Antoni, MH; Lattie, EG; Jutagir, DR; Czaja, S; Perdomo, D; Lechner, SC; Stagl, JM; Bouchard, LC; Gudenkauf, LM; Traeger, L; Fletcher, MA; Klimas, NG (2015), "Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors", Fatigue: Biomedicine, Health & Behavior, 3 (3): 142-155, doi:10.1080/21641846.2015.1039289, PMID 26180660 
  31. Klimas, N.G.; Ironson, G.; Carter, A.; Balbin, E.; Bateman, L.; Felsenstein, D.; Levine, S.; Peterson, D.; Chiu, K.; Allen, A.; Cunningham, K.; Gottschalk, C.G.; Fletcher, M; Hornig, M.; Canning, C.; Komaroff, A.L. (2015), "Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, 3 (2): 75-96, doi:10.1080/21641846.2015.1023652 
  32. Craddock, Travis J.A.; Harvey, Jeanna M.; Nathanson, Lubov; Barnes, Zachary M.; Klimas, Nancy G.; Fletcher, Mary Ann; Broderick, Gordon (Jul 9, 2015). "Using gene expression signatures to identify novel treatment strategies in gulf war illness". BMC Medical Genomics. 8. doi:10.1186/s12920-015-0111-3. ISSN 1755-8794. PMC 4495687Freely accessible. PMID 26156520. 
  33. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Ironson, Gail H.; Wohlgemuth, William; Vera Nunez, Maria; Garcia, Lina; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2016), "Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women", Journal of Neuroimmunology, 0 (0), doi:10.1016/j.jneuroim.2016.12.008 
  34. Harvey, Jeanna M; Broderick, Gordon; Bowie, Alanna; Barnes, Zachary M; Katz, Ben Z; O'Gorman, Maurice R; Vernon, Suzanne D; Fletcher, Mary Ann; Klimas, Nancy; Taylor, Renee (2016), "Tracking post-infectious fatigue in clinic using routine Lab tests.", BMC Pediatrics, 16 (54), doi:10.1186/s12887-016-0596-8 
  35. Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth; Katz, Ben; Klimas, Nancy; Fletcher, Mary Ann (2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, 17 (3), doi:10.1186/s12865-016-0142-3 
  36. Hall, DL; Lattie, EG; Milrad, SF; Czaja, S; Fletcher, MA; Klimas, N; Perdomo, D; Antoni, MH (2017), "Telephone-administered versus live group cognitive behavioral stress management for adults with CFS", J Psychosom Res, 93: 41-47, doi:10.1016/j.jpsychores.2016.12.004 
  37. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2017), "Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model", Int J Psychophysiol, 0 (0), doi:10.1016/j.ijpsycho.2017.09.009 
  38. Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (Jul 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PlosOne. doi:10.1371/journal.pone.0201066. 
  39. Klimas, N.G.; Fletcher, M.A.; Abreu, M.M.; Aenlle, K.; Craddock, T.; Broderick, G. (Feb 2019). "From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story". Brain, Behavior, and Immunity. 76: e40. doi:10.1016/j.bbi.2018.11.301. 
  40. Morris, Matthew C.; Cooney, Katherine E.; Sedghamiz, Hooman; Abreu, Maria; Collado, Fanny; Balbin, Elizabeth G.; Craddock, Travis J.A.; Klimas, Nancy G.; Broderick, Gordon; Fletcher, Mary Ann (Mar 2019). "Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.03.002. 
  41. Richman, Spencer; Morris, Matthew C.; Broderick, Gordon; Craddock, Travis J.A.; Klimas, Nancy G.; Fletcher, Mary Ann (Mar 2019). "Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.02.011. 
  42. Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (Mar 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011. 
  43. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Ironson, Gail; Doss, Brian D.; Mendez, Armando; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (Jul 2019). "Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue". Social Science & Medicine: 112392. doi:10.1016/j.socscimed.2019.112392. 

Myalgic encephalomyelitis or chronic fatigue syndrome

Myalgic encephalomyelitis or M.E. has different diagnostic criteria to chronic fatigue syndrome; neurological symptoms are required but fatigue is an optional symptom.<ref name="ICP2011primer">{{Citation


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history