Institute for Neuro Immune Medicine

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The Institute for Neuro-Immune Medicine (INIM), at Nova Southeastern University in Fort Lauderdale, Florida, United States, is led by Doctor Nancy Klimas.

Notable people[edit | edit source]

Notable studies[edit | edit source]

  • 2018, Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns[4]

Current research[edit | edit source]

Crowd-sourced ME/CFS Gene Study[edit | edit source]

Main article: ME/CFS Gene Study

Beginning in 2015, Dr. Klimas has asked patients to provide their genetic data (either via Ancestry.com or 23andMe) to develop a large-scale study to look for patterns and subgroups in the genetics of ME/CFS patients.[5]

ME/CFS Detecting Myotoxin Subgroup[edit | edit source]

This is a pilot study to look at mycotoxins (toxic metabolites produced by molds/fungi) in patients with ME/CFS. It aims to:

  • find out whether the Environmental Exposure Questionnaire (EEQ) can be used to assess for mycotoxin exposure in ME/CFS patients
  • assess if the mycotoxin exposure results in more severe symptoms in ME/CFS patients
  • future studies will use the blood samples collected to discover if there is a "specific immune or metabolic dysfunction, or epigenetic changes" related to mycotoxin exposure in ME/CFS patients[6]

Clinical Nutrition Profile for ME/CFS[edit | edit source]

The Clinical Nutrition Profile (CNP) project aims to create a profile of people with ME/CFS based on nutritional biomarkers, their dietary intake and other clinically relevant data. By investigating nutritional patterns and deficiencies associated with the ME/CFS it could help "identifying disease targets, improving overall organ system function, allowing body to heal and potentially resetting homeostatic function" to improve patient response to current treatments.[7]

Funding[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ NSU. "Institute for Neuro-Immune Medicine Clinic". NSU. Retrieved Jan 13, 2019. 
  2. ↑ "Mary Ann Fletcher Joins Nova Southeastern University as Schemel Professor for Neuro Immune Medicine | NSU Newsroom". nsunews.nova.edu. Retrieved Jan 13, 2019. 
  3. ↑ 3.03.1 NSU. "Our Team | Clinical Research | NSU Institute for Neuro Immune Medicine". NSU. Retrieved Jan 13, 2019. 
  4. ↑ Nathanson, Lubov; Klimas, Nancy G.; Fletcher, Mary Ann; Beljanski, Vladimir; Rose, Natasha; Sarria, Leonor; Oltra, Elisa; Trivedi, Malav S. (Jul 23, 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PLOS ONE. 13 (7): e0201066. doi:10.1371/journal.pone.0201066. ISSN 1932-6203. PMID 30036399. 
  5. ↑ Gene Study video invitation to participate
  6. ↑ "19-20 PFRDG Detecting Mycotoxin Subgroup". Nova Southeastern University. Retrieved Jun 7, 2020. 
  7. ↑ "Clinical Nutrition Profile for ME/CFS| Clinical Research". NSU Institute for Neuro Immune Medicine. Retrieved Jun 7, 2020. 

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

mycotoxin - "a poisonous substance produced by a fungus and especially a mold"

metabolite - A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

mycotoxin - "a poisonous substance produced by a fungus and especially a mold"

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.

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