Stress, particularly chronic stress, is considered a potential trigger for ME/CFS. It is also thought to worsen ME/CFS symptoms. ME patients are usually advised to avoid stress wherever possible.
Notable studies[edit | edit source]
Several studies found it is not uncommon to experience major psychological chronic stress (from events such as divorce, bereavement or serious financial worries) in the year prior to developing ME/CFS.
Chronic psychological stress elevates cortisol which suppresses the Th1 antiviral/intracellular immune response and the T-cell response. Chronic stress has also been shown to greatly increase susceptibility to viral infection. This increased susceptibility is not observed after short-term acute stress (periods of stress of less than 1 month duration).
As ME/CFS normally appears after acute viral infection, the presence of chronic stress may weaken immunity and allow a normally mild virus to trigger the serious disease of ME/CFS.
See also[edit | edit source]
References[edit | edit source]
- Hatcher, Simon; House, Allan (Oct 2003). "Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study". Psychological Medicine. 33 (7): 1185–1192. doi:10.1017/s0033291703008274. ISSN 0033-2917. PMID 14580073.
- Theorell, T.; Blomkvist, V.; Lindh, G.; Evengård, B. (May 1999). "Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis". Psychosomatic Medicine. 61 (3): 304–310. ISSN 0033-3174. PMID 10367610.
- Salit, Irving E. (Jan 1, 1997). "Precipitating factors for the chronic fatigue syndrome". Journal of Psychiatric Research. 31 (1): 59–65. doi:10.1016/S0022-3956(96)00050-7. ISSN 0022-3956.
- Dhabhar, Firdaus S (Mar 15, 2008). "Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology". Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology. 4 (1): 2–11. doi:10.1186/1710-1492-4-1-2. ISSN 1710-1484. PMC . PMID 20525121.
- Murphy, Michael L. M.; Cohen, Sheldon; Janicki-Deverts, Denise; Doyle, William J. (Jun 20, 2017). "Offspring of parents who were separated and not speaking to one another have reduced resistance to the common cold as adults". Proceedings of the National Academy of Sciences of the United States of America. 114 (25): 6515–6520. doi:10.1073/pnas.1700610114. ISSN 1091-6490. PMC . PMID 28584098.
- Cohen, S.; Frank, E.; Doyle, W. J.; Skoner, D. P.; Rabin, B. S.; Gwaltney, J. M. (May 1998). "Types of stressors that increase susceptibility to the common cold in healthy adults". Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association. 17 (3): 214–223. doi:10.1037//0278-622.214.171.124. ISSN 0278-6133. PMID 9619470.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.