Sex differences in myalgic encephalomyelitis and chronic fatigue syndrome
Epidemiology[edit | edit source]
A higher preponderance of women has also been noted in numerous outbreaks including Los Angeles, Akureyri, Rockville, MD, Royal Free Hospital, and Punta Gorda, Florida. In some cases, this was thought to do with the occupational hazard of nursing, but this female-skewed sex ratio was also found in several outbreaks among the general population. However, in other outbreaks, including the 1949-1953 Adelaide outbreak and an outbreak in northern England in 1955, a 1:1 gender ratio was reported. In Akureyri, a significantly higher incidence rate was found among adult women but not in patients under twenty.
A 2015 epidemiology study of ME/CFS in Spain found that although the most common trigger for both males and females was infection, the mean age of symptoms onset was lower in males than females. Males reported less pain and fewer comorbidities. In this cohort, fibromyalgia was present in 29% of the males vs 58% in the females.
Physiology[edit | edit source]
Naviaux found women with ME/CFS, but not men, generally had disturbed fatty acid and endocannabinoid metabolism. Men, but not women, generally showed increased serine and threonine concentrations. 
Notable studies[edit | edit source]
- 2015, Gender Differences in Chronic Fatigue Syndrome(Full Text)
- 2011, Gynecological History in Chronic Fatigue Syndrome: A Population-Based Case-Control Study
- 2002, Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia.
See also[edit | edit source]
References[edit | edit source]
- Bakken, Inger Johanne; Tveito, Kari; Gunnes, Nina; Ghaderi, Sara; Stoltenberg, Camilla; Trogstad, Lill; Håberg, Siri Eldevik; Magnus, Per (Oct 1, 2014). "Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012". BMC medicine. 12: 167. doi:10.1186/s12916-014-0167-5. ISSN 1741-7015. PMC . PMID 25274261.
- Jason, LA; Richman, JA; Rademaker, AW; Jordan, KM; Plioplys, AV; Taylor, RR; McCready, W; Huang, C; Plioplys, S (1999), "A Community-Based Study of Chronic Fatigue Syndrome", Arch Intern Med, 159 (18): 2129-2137, doi:10.1001/archinte.159.18.2129
- Gunn, Walter (1993). "Epidemiology of Chronic Fatigue Syndrome: The Centers for Disease Control Study". Ciba Foundation Symposium 173 ‐ Chronic Fatigue Syndrome.
- Parish, JG (1978). "Early outbreaks of 'epidemic neuromyasthenia'". Postgraduate Medical Journal. 54: 711–7.
- Shelokov, Alexis; Habel, Karl; Verder, Elizabeth; Welsh, William (August 1957), "Epidemic Neuromyasthenia — An Outbreak of Poliomyelitis-like Illness in Student Nurses", New England Journal of Medicine, 1957 (257): 345-355, doi:10.1056/NEJM195708222570801
- Gilliam, A.G. (1938), "Epidemiological Study Of An Epidemic, Diagnosed As Poliomyelitis, Occurring Among The Personnel Of The Los Angeles County General Hospital During The Summer Of 1934", Public health bulletin, 1936-1938, no.231-240
- Acheson, E.D. (1959), "The Clinical Syndrome Variously Called Benign Myalgic Encephalomyelitis, Iceland Disease and Epidemic Neuromyasthenia" (PDF), American Journal of Medicine, 26 (4): 569–595
- Poskanzer, David C.; Henderson, Donald A.; Kunkle, E. Charles; Kalter, Seymour S.; Clement, Walter B.; Bond, James O. (1957), "Epidemic Neuromyasthenia — An Outbreak in Punta Gorda, Florida", New England Journal of Medicine, 1957 (257): 356-364, doi:10.1056/NEJM195708222570802, PMID 13464939
- An Outbreak of Encephalomyelitis in the Royal Free Hospital Group, London, in 1955 - The Medical Staff Of The Royal Free Hospital
- Sigurdsson, B (September 1950). "A disease epidemic in Iceland simulating poliomyelitis". American Journal of Hygiene. 52: 222–38.
- Faro, Mónica; Sáez-Francàs, Naia; Castro-Marrero, Jesús; Aliste, Luisa; Fernández de Sevilla, Tomás; Alegre, Jose (2015), "Gender Differences in Chronic Fatigue Syndrome", Reumatologia clinica, 12 (2), doi:10.1016/j.reuma.2015.05.007
- "Naviaux's metabolism paper is about as big as you think - #MEAction". #MEAction. Aug 30, 2016. Retrieved Nov 5, 2018.
- Faro, Mònica; Sàez-Francás, Naia; Castro-Marrero, Jesús; Aliste, Luisa; Fernández de Sevilla, Tomás; Alegre, José (Mar 2016). "Diferencias de género en pacientes con síndrome de fatiga crónica". Reumatología Clínica. 12 (2): 72–77. doi:10.1016/j.reuma.2015.05.007. ISSN 1699-258X.
- Boneva, Roumiana S.; Maloney, Elizabeth M.; Lin, Jin-Mann; Jones, James F.; Wieser, Friedrich; Nater, Urs M.; Heim, Christine M.; Reeves, William C. (Jan 2011). "Gynecological history in chronic fatigue syndrome: a population-based case-control study". Journal of Women's Health (2002). 20 (1): 21–28. doi:10.1089/jwh.2009.1900. ISSN 1931-843X. PMC . PMID 21091051.
- Asbring, Pia; Närvänen, Anna-Liisa (February 2002), "Women's experiences of stigma in relation to chronic fatigue syndrome and fibromyalgia", Qualitative Health Research, 12 (2): 148–160, ISSN 1049-7323, PMID 11837367
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.