Luis Nacul

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Dr Luis Carlos Nacul is a Clinical Associate Professor and researcher at the London School of Hygiene and Tropical Medicine in London, United Kingdom. He leads the CureME team and the UK ME/CFS biobank. He served as a Member Substitute for EUROMENE, an international not-for-profit organization for ME/CFS research.

He is a doctor and general practitioner, with training across medicine, epidemiology and public health.[1] In 2018, Dr Nacul was appointed to the review committee for the NICE guidelines for ME/CFS used by the British NHS.[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Dr Nacul serves on the Fatigue Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[3]

Notable studies and publications[edit | edit source]

  • 2007, The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[4] - (Abstract)
  • 2011, Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care[5] - (Full Text)
  • 2011, Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis[6] - (Full Text)
  • 2011, The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers[7] - (Full Text)
  • 2014, Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: A proposed protocol[8] - (Full Text)
  • 2017, How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?[9] - (Full text)
  • 2017, Public Review - Draft of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials[10] - (Full Text)
  • 2017, Editorial - Using a participatory approach to develop and implement the UK ME/CFS Biobank[11]
  • 2017, Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome[12]
  • 2017, The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis[13] - (Full text)
  • 2018, Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls[14] - (Full Text)
  • 2018, Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review[15] - (Full text)
  • 2018, Hand grip strength as a clinical biomarker for ME/CFS and Disease Severity[16] - (Abstract)
  • 2018, The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[17] - (Full text)
  • 2019, Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study[18] - (Full text)
  • 2019, Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study[19] - (Abstract)
  • 2019, Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[20] - (Full text)
  • 2019, HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome[21] - (Full text)
  • 2019, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections[22] - (Abstract)
  • 2019, A logistic regression analysis of risk factors in ME/CFS pathogenesis[23] - (Full text)
  • 2019, Rethinking the Standard of Care for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[24] - (Full text)
  • 2019, How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS[25] - (Full text)
  • 2020, Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology[26] - (Full text)
  • 2021, The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies[27] - (Full text)
  • 2021, European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe[28] - (Full text)
  • 2022, Systematic review and meta‐analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[29] - (Full text)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ London School of Hygiene and Tropical Medicine. "Luis Nacul".
  2. ↑ NICE (October 28, 2018). "Committee member list | NICE CG53 CFS/ME guidance update". nice.org.uk. Retrieved October 20, 2018.
  3. ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
  4. ↑ Osoba, Tolu; Pheby, Derek; Gray, Selena; Nacul, Luis (2007), "The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 14 (4): 61-84, doi:10.3109/10573320802092112
  5. ↑ Nacul, L.C.; Lacerda, E.M.; Pheby, D.; Campion, P.; Molokhia, M.; Fayyaz, S.; Leite, JCDC; Poland, F; Howe, A; de L. Drachler, Maria (2011). "Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care". BMC Medicine. 9 (91). doi:10.1186/1741-7015-9-91. PMC 3170215.
  6. ↑ de Carvalho Leite, JC; de L Drachler, M; Killett, A; Kale, S; Nacul, L; McArthur, M; Hong, CS; O'Driscoll, L; Pheby, D; Campion, P; Lacerda, E; Poland, F (2011), "Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis", International Journal for Equity in Health, 2 (10): 46, doi:10.1186/1475-9276-10-46, PMC 3229491
  7. ↑ Nacul, Luis C; Lacerda, Eliana M; Campion, Peter; Pheby, Derek; Drachler, Maria de L; Leite, José C; Poland, Fiona; Howe, Amanda; Fayyaz, Shagufta (May 27, 2011). "The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers". BMC Public Health. 11 (1): 402. doi:10.1186/1471-2458-11-402. ISSN 1471-2458. PMC 3123211. PMID 21619607.
  8. ↑ Nacul, Luis; O'Donovan, Dominic G; Lacerda, Eliana M; Gveric, Djordje; Goldring, Kirstin; Hall, Alison; Bowman, Erinna; Pheby, Derek (2014). "Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol". BMC Research Notes. 7 (1): 370. doi:10.1186/1756-0500-7-370. ISSN 1756-0500. PMC 4076507. PMID 24938650.
  9. ↑ Nacul, Luis; Lacerda, Eliana M; Kingdon, Caroline C; Curran, Hayley; Bowman, Erinna W (March 1, 2017). "How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?". Journal of Health Psychology: 1359105317695803. doi:10.1177/1359105317695803. ISSN 1359-1053. PMC 5581258. PMID 28810428.
  10. ↑ Cella, David; Dimmock, Mary; Friedberg, Fred; Lin, Jin-Mann Sally; Nacul, Luis; Saligan, Leorey (December 2017), NINDS/CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials (PDF)
  11. ↑ Lacerda, Eliana M.; Kingdon, Caroline C.; Bowman, Erinna W.; Nacul, Luis (2017). "Using a participatory approach to develop and implement the UK ME/CFS Biobank". Fatigue: Biomedicine, Health & Behavior. doi:10.1080/21641846.2018.1396021.
  12. ↑ Nacul, Luis; Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Lacerda, Eliana M. (2017). "Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 5 (1): 1–4. doi:10.1080/21641846.2017.1273863. ISSN 2164-1846. PMC 5730342. PMID 29250461.
  13. ↑ Lacerda, Eliana M; Bowman, Erinna W; Cliff, Jacqueline M; Kingdon, Caroline C; King, Elizabeth C; Lee, Ji-Sook; Clark, Taane G; Dockrell, Hazel M; Riley, Eleanor M; Curran, Hayley; Nacul, Luis (February 20, 2017). "The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis". Open Journal of Bioresources. 4. doi:10.5334/ojb.28. ISSN 2056-5542. PMC 5482226. PMID 28649428.
  14. ↑ Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Nacul, Luis; Lacerda, Eliana M. (March 13, 2018). "Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls". PharmacoEconomics - Open. doi:10.1007/s41669-018-0071-6. ISSN 2509-4262.
  15. ↑ Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (September 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183.
  16. ↑ Nacul, Luis Carlos; Mudie, Kathleen; Kingdon, Caroline; Clark, Taane G.; Lacerda, Eliana Mattos (2018). "Hand grip strength as a clinical biomarker for ME/CFS and disease severity". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.00992. ISSN 1664-2295.
  17. ↑ Lacerda, Eliana; Mudie, Kathleen; Butterworth, Jack D.; Kingdon, Caroline C.; O'Boyle, Shennae; Nacul, Luis (December 4, 2018). "The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.01026. ISSN 1664-2295. PMID 30564186.
  18. ↑ Lacerda, Eliana M.; McDermott, Clare; Kingdon, Caroline C.; Butterworth, Jack; Cliff, Jacqueline M.; Nacul, Luis (January 10, 2019). "Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study". Health Expectations. 0 (0). doi:10.1111/hex.12857. ISSN 1369-7625. PMID 30632248.
  19. ↑ Nacul, Luis; de Barros, Barbara; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Mudie, Kathleen; Dockrell, Hazel M.; Lacerda, Eliana M. (April 10, 2019). "Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study". Diagnostics. 9 (2): 41. doi:10.3390/diagnostics9020041. ISSN 2075-4418.
  20. ↑ Cliff, Jacqueline M.; King, Elizabeth C.; Lee, Ji-Sook; Sepúlveda, Nuno; Wolf, Asia-Sophia; Kingdon, Caroline; Bowman, Erinna; Dockrell, Hazel M.; Nacul, Luis; Lacerda, Eliana; Riley, Eleanor (April 16, 2019). "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00796. ISSN 1664-3224.
  21. ↑ Rodrigues, Lucas S; Nali, Luiz H da Silva; Leal, Cibele O D; Sabino, Ester C; Lacerda, Eliana M; Kingdon, Caroline C; Nacul, Luis; Romano, Camila M (July 5, 2019). "HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome". bioRxiv. doi:10.1101/693465.
  22. ↑ Sepúlveda, Nuno; Carneiro, Jorge; Eliana M. Lacerda, Eliana M.; Nacul, Luis C. (October 2019). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections". Frontiers in Immunology. doi:10.3389/fimmu.2019.02684.
  23. ↑ Lacerda, Eliana M.; Geraghty, Keith; Kingdon, Caroline C.; Palla, Luigi; Nacul, Luis (December 2019). "A logistic regression analysis of risk factors in ME/CFS pathogenesis". BMC Neurology. 19 (1): 275. doi:10.1186/s12883-019-1468-2. ISSN 1471-2377.
  24. ↑ Friedberg, Fred; Sunnquist, Madison; Nacul, Luis (March 1, 2020). "Rethinking the Standard of Care for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of General Internal Medicine. 35 (3): 906–909. doi:10.1007/s11606-019-05375-y. ISSN 1525-1497. PMC 7080939. PMID 31637650.
  25. ↑ Nacul, Luis; O'Boyle, Shennae; Nacul, Flavio E.; Mudie, Kathleen; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Dockrell, Hazel M.; Lacerda, Eliana M. (September 17, 2019). "How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS". Preprints. doi:10.20944/preprints201909.0188.v1.
  26. ↑ Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557.
  27. ↑ Malato, João; Sotzny, Franziska; Bauer, Sandra; Freitag, Helma; Fonseca, André; Grabowska, Anna D; Graça, Luís; Cordeiro, Clara; Nacul, Luís; Lacerda, Eliana M; Castro-Marrero, Jesus; Scheibenbogen, Carmen; Westermeier, Francisco; Sepúlveda, Nuno (March 24, 2021). "The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies". medRxiv. doi:10.1101/2021.03.23.21254175. PMID 33791744.
  28. ↑ Nacul, Luis; Authier, François Jérôme; Scheibenbogen, Carmen; Lorusso, Lorenzo; Helland, Ingrid Bergliot; Martin, Jose Alegre; Sirbu, Carmen Adella; Mengshoel, Anne Marit; Polo, Olli; Behrends, Uta; Nielsen, Henrik; Grabowski, Patricia; Sekulic, Slobodan; Sepulveda, Nuno; Estévez-López, Fernando; Zalewski, Pawel; Pheby, Derek F.H.; Castro-Marrero, Jesus; Sakkas, Giorgos K.; Capelli, Enrica; Brundsdlund, Ivan; Cullinan, John; Krumina, Angelika; Bergquist, Jonas; Murovska, Modra; Vermuelen, Ruud C.W.; Lacerda, Eliana M. (May 2021). (EUROMENE). "European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe". Medicina. 57 (5): 510. doi:10.3390/medicina57050510. PMC 8161074. PMID 34069603.
  29. ↑ Aoun Sebaiti, Mehdi; Hainselin, Mathieu; Gounden, Yannick; Sirbu, Carmen Adella; Sekulic, Slobodan; Lorusso, Lorenzo; Nacul, Luis; Authier, François Jérôme (February 9, 2022). "Systematic review and meta-analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Scientific Reports. 12 (1): 2157. doi:10.1038/s41598-021-04764-w. ISSN 2045-2322. PMC 8828740. PMID 35140252.
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