Luis Nacul

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Dr Luis Carlos Nacul is a Clinical Associate Professor and researcher at the London School of Hygiene and Tropical Medicine in London, United Kingdom. He leads the CureME team and the UK ME/CFS biobank. He serves as a Member Substitute for EUROMENE, an international not-for-profit organization for ME/CFS research.

He is a doctor and general practitioner, with training across medicine, epidemiology and public health.[1] In 2018, Dr Nacul was appointed to the review committee for the NICE guidelines for ME/CFS used by the British NHS.[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Dr Nacul serves on the Fatigue Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention.[3]

Notable studies and writings related to ME/CFS[edit | edit source]


Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. London School of Hygiene and Tropical Medicine. "Luis Nacul". 
  2. NICE (Oct 28, 2018). "Committee member list | NICE CG53 CFS/ME guidance update". nice.org.uk. Retrieved Oct 20, 2018. 
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019. 
  4. Osoba, Tolu; Pheby, Derek; Gray, Selena; Nacul, Luis (2007), "The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 14 (4): 61-84, doi:10.3109/10573320802092112 
  5. Nacul, L. C.; Lacerda, E. M.; Pheby, D.; Campion, P.; Molokhia, M.; Fayyaz, S.; Leite, JCDC; Poland, F; Howe, A; Drachler, Maria (2011). "Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care". BMC Medicine. 9 (91). doi:10.1186/1741-7015-9-91. PMC 3170215Freely accessible. 
  6. de Carvalho Leite, JC; de L Drachler, M; Killett, A; Kale, S; Nacul, L; McArthur, M; Hong, CS; O'Driscoll, L; Pheby, D; Campion, P; Lacerda, E; Poland, F (2011), "Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis", International Journal for Equity in Health, 2 (10): 46, doi:10.1186/1475-9276-10-46, PMC 3229491Freely accessible 
  7. Nacul, Luis C; Lacerda, Eliana M; Campion, Peter; Pheby, Derek; Drachler, Maria de L; Leite, José C; Poland, Fiona; Howe, Amanda; Fayyaz, Shagufta (May 27, 2011). "The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers". BMC Public Health. 11 (1). doi:10.1186/1471-2458-11-402. ISSN 1471-2458. PMC 3123211Freely accessible. PMID 21619607. 
  8. Nacul, Luis; O’Donovan, Dominic G; Lacerda, Eliana M; Gveric, Djordje; Goldring, Kirstin; Hall, Alison; Bowman, Erinna; Pheby, Derek (2014). "Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol". BMC Research Notes. 7 (1): 370. doi:10.1186/1756-0500-7-370. ISSN 1756-0500. PMC 4076507Freely accessible. PMID 24938650. 
  9. Nacul, Luis; Lacerda, Eliana M; Kingdon, Caroline C; Curran, Hayley; Bowman, Erinna W (Mar 1, 2017). "How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?". Journal of Health Psychology: 1359105317695803. doi:10.1177/1359105317695803. ISSN 1359-1053. PMC 5581258Freely accessible. PMID 28810428. 
  10. Cella, David; Dimmock, Mary; Friedberg, Fred; Lin, Jin-Mann Sally; Nacul, Luis; Saligan, Leorey (Dec 2017), NINDS/CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials (PDF) 
  11. Lacerda, Eliana M.; Kingdon, Caroline C.; Bowman, Erinna W.; Nacul, Luis (2017). "Using a participatory approach to develop and implement the UK ME/CFS Biobank". Fatigue: Biomedicine, Health & Behavior. doi:10.1080/21641846.2018.1396021. 
  12. Nacul, Luis; Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Lacerda, Eliana M. (2017). "Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 5 (1): 1–4. doi:10.1080/21641846.2017.1273863. ISSN 2164-1846. PMC 5730342Freely accessible. PMID 29250461. 
  13. Lacerda, Eliana M; Bowman, Erinna W; Cliff, Jacqueline M; Kingdon, Caroline C; King, Elizabeth C; Lee, Ji-Sook; Clark, Taane G; Dockrell, Hazel M; Riley, Eleanor M; Curran, Hayley; Nacul, Luis (Feb 20, 2017). "The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis". Open Journal of Bioresources. 4. doi:10.5334/ojb.28. ISSN 2056-5542. PMC 5482226Freely accessible. PMID 28649428. 
  14. Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Nacul, Luis; Lacerda, Eliana M. (Mar 13, 2018). "Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls". PharmacoEconomics - Open. doi:10.1007/s41669-018-0071-6. ISSN 2509-4262. 
  15. Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (Sep 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183. 
  16. Nacul, Luis Carlos; Mudie, Kathleen; Kingdon, Caroline; Clark, Taane G.; Lacerda, Eliana Mattos (2018). "Hand grip strength as a clinical biomarker for ME/CFS and disease severity". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.00992. ISSN 1664-2295. 
  17. Lacerda, Eliana; Mudie, Kathleen; Butterworth, Jack D.; Kingdon, Caroline C.; O'Boyle, Shennae; Nacul, Luis (Dec 4, 2018). "The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.01026. ISSN 1664-2295. PMID 30564186. 
  18. Lacerda, Eliana M.; McDermott, Clare; Kingdon, Caroline C.; Butterworth, Jack; Cliff, Jacqueline M.; Nacul, Luis (Jan 10, 2019). "Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study". Health Expectations. 0 (0). doi:10.1111/hex.12857. ISSN 1369-7625. PMID 30632248. 
  19. Nacul, Luis; de Barros, Barbara; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Mudie, Kathleen; Dockrell, Hazel M.; Lacerda, Eliana M. (Apr 10, 2019). "Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study". Diagnostics. 9 (2): 41. doi:10.3390/diagnostics9020041. ISSN 2075-4418. 
  20. Cliff, Jacqueline M.; King, Elizabeth C.; Lee, Ji-Sook; Sepúlveda, Nuno; Wolf, Asia-Sophia; Kingdon, Caroline; Bowman, Erinna; Dockrell, Hazel M.; Nacul, Luis; Lacerda, Eliana; Riley, Eleanor (Apr 16, 2019). "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00796. ISSN 1664-3224. 
  21. Rodrigues, Lucas S; Nali, Luiz H da Silva; Leal, Cibele O D; Sabino, Ester C; Lacerda, Eliana M; Kingdon, Caroline C; Nacul, Luis; Romano, Camila M (Jul 5, 2019). "HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome". bioRxiv. doi:10.1101/693465. 
  22. Sepúlveda, Nuno; Carneiro, Jorge; Eliana M. Lacerda, Eliana M.; Nacul, Luis C. (Oct 2019). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections". Frontiers in Immunology. doi:10.3389/fimmu.2019.02684. 
  23. Lacerda, Eliana M.; Geraghty, Keith; Kingdon, Caroline C.; Palla, Luigi; Nacul, Luis (Dec 2019). "A logistic regression analysis of risk factors in ME/CFS pathogenesis". BMC Neurology. 19 (1): 275. doi:10.1186/s12883-019-1468-2. ISSN 1471-2377. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Accuracy - The "closeness of an observation to the true clinical state". With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.