Jesús Castro-Marrero

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Source:Vall d'Hebron Research Institute (VHIR)

Jesús Castro-Marrero, PhD, (also known as Jesus Castro) works at Cornell ME/CFS Collaborative Research Center, New York, US. His research focuses on Extracellular Vesicles/Exosomes biology and decoding differences in the mRNA and miRNA expression cargo from Extracellular Vesicles (EVs) and blood immune cells (peripheral blood mononuclear cells) before and after a 24 hour CPET challenge in a gender-specific manner in individuals with ME/CFS.

Previously, he was a Senior Research Associate in Biochemistry and Molecular Biology at the Vall d’Hebron University Hospital Research Institute (VHIR), Barcelona, Spain.[1]

EUROMENE[edit | edit source]

Dr. Castro-Marrero is a Working Group Leader on Epidemiology of ME/CFS across Europe on behalf of the EUROMENE, a European Union not-for-profit research organization committed to tackling the cause and treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[2]

Education[edit | edit source]

  • 1987 - B.S. in Biochemistry, School of Biological Sciences, University of Havana, Cuba
  • 1999 - Ph.D. in Biochemistry and Molecular Biology, Valladolid University School of Medicine, Spain

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Vall d'Hebron Research Institute (VHIR)". en.vhir.org. Retrieved July 15, 2019.
  2. ↑ "Action CA15111". COST. Retrieved April 24, 2020.
  3. ↑ Curriu, Marta; Carrillo, Jorge; Massanella, Marta; Rigau, Josepa; Alegre, José; Puig, Jordi; Garcia-Quintana, Ana M; Castro-Marrero, Jesús; Negredo, Eugènia; Clotet, Bonaventura; Cabrera, Cecilia; Blanco, Julià (2013), "Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome", Journal of Translational Medicine, 11 (68), doi:10.1186/1479-5876-11-68
  4. ↑ Castro-Marrero, J.; Cordero, M.D.; Sáez-Francas, N.; Jimenez-Gutierrez, C.; Aguilar-Montilla, F.J.; Aliste, L.; Alegre-Martin, J. (2013), "Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?", Antioxidants & Redox Signaling, 19 (15): 1855-1860, doi:10.1089/ars.2013.5346, PMID 23600892
  5. ↑ Faro, M.; Sáez-Francàs, N.; Castro-Marrero, J.; Aliste, L.; Collado, A.; Alegre, J. (2014), "Impact of the fibromyalgia in the chronic fatigue syndrome", Medicina Clinica (Barc), 142 (12): 519-525, doi:10.1016/j.medcli.2013.06.030, PMID 24387955
  6. ↑ Castro-Marrero, J.; Cordero, M.D.; Segundo, M.J.; Sáez-Francàs, N.; Calvo, N.; Román-Malo, L.; Aliste, L.; Fernández de Sevilla, T.; Alegre, J. (2015), "Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome?", Antioxidants & Redox Signaling, 22 (8): 679–685, doi:10.1089/ars.2014.6181, PMID 25386668
  7. ↑ Calvo, N.; Sáez-Francas, N.; Valero, S.; Castro-Marrero, J.; Alegre, J.; Casas, M. (2015), "Diagnostic concordance between categorical and dimensional instrument to assess personality in chronic fatigue syndrome: PDQ-4+ and TCI-R", European Journal of Psychological Assessment, 33: 158-165, doi:10.1027/1015-5759/a000281
  8. ↑ Sáez-Francàs, Naia; Calvo, Natalia; Alegre, José; Castro-Marrero, Jesús; Casas, Miguel (2015), "Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology", Comprehensive Psychiatry, 62: 13-19, doi:10.1016/j.comppsych.2015.06.010
  9. ↑ Faro, Mónica; Sáez-Francàs, Naia; Castro-Marrero, Jesús; Aliste, Luisa; Fernández de Sevilla, Tomás; Alegre, Jose (2015), "Gender Differences in Chronic Fatigue Syndrome", Reumatologia clinica, 12 (2), doi:10.1016/j.reuma.2015.05.007
  10. ↑ Scheibenbogen, Carmen; Freitag, Helma; Blanco, Julià; Capelli, Enrica; Lacerda, Eliana; Authier, Jerome; Meeus, Mira; Castro Marrero, Jesus; Nora-Krukle, Zaiga; Oltra, Elisa; Strand, Elin Bolle; Shikova, Evelina; Sekulic, Slobodan; Murovska, Modra (July 26, 2017). "The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE". Journal of Translational Medicine. 15 (1). doi:10.1186/s12967-017-1263-z. ISSN 1479-5876. PMC 5530475. PMID 28747192.
  11. ↑ Castro-Marrero, J. (2017), "Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Rome", British Journal of Pharmacology, 174 (5): 345–369, doi:10.1111/bph.13702, PMID 28052319
  12. ↑ Castro-Marrero, J.; Faro, M.; Aliste, L.; Sáez-Francàs, N.; Calvo, N.; Martínez-Martínez, A.; de Sevilla, T.F.; Alegre, J. (2017), "Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study", Psychosomatics, 58 (5): 533 - 543, doi:10.1016/j.psym.2017.04.010
  13. ↑ Cambras, T.; Castro-Marrero, J.; Zaragoza, MC.; Díez-Noguera, A.; Alegre, J. (2018), "Circadian rhythm abnormalities and autonomic dysfunction in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", PLoS ONE, 13 (6): e0198106, doi:10.1371/journal.pone.0198106
  14. ↑ Castro-Marrero, Jesús; Zaragozá, Maria Cleofé; González-Garcia, Sergio; Aliste, Luisa; Sáez-Francàs, Naia; Romero, Odile; Ferré, Alex; Fernández de Sevilla, Tomás; Alegre, José (2018), "Poor self-reported sleep quality and health-related quality of life in patients with chronic fatigue syndrome/myalgic encephalomyelitis", J Sleep Res: e12703, doi:10.1111/jsr.12703, PMID 29770505
  15. ↑ Sotzny, Franziska; Blanco, Julià; Capelli, Enrica; Castro-Marrero, Jesús; Steiner, Sophie; Murovska, Modra; Scheibenbogen, Carmen (2018), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease", Autoimmunity Reviews, doi:10.1016/j.autrev.2018.01.009
  16. ↑ Castro-Marrero, Jesús; Serrano-Pertierra, Esther; Oliveira-Rodríguez, Myriam; Zaragozá, Maria Cleofé; Martínez-Martínez, Alba; Blanco-López, María del Carmen; Alegre, José (2018), "Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study", Journal of Extracellular Vesicles, 7 (1), doi:10.1080/20013078.2018.1453730
  17. ↑ Calvo, Natalia; Pueyo, Natalia; Gutiérrez, Fernando; Ferrer, Marc; Castro-Marrero, Jesús; Alegre, José; Casas, Miquel; Ramos Quiroga, Josep-Antoni; Sáez-Francàs, Naia (July 2018). "Dimensional Personality Assessment among a Chronic Fatigue Syndrome (CFS) sample with Personality Inventory for DSM-5 (PID-5)". Actas Espanolas De Psiquiatria. 46 (4): 125–132. ISSN 1578-2735. PMID 30079926.
  18. ↑ Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (September 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183.
  19. ↑ Castro-Marrero, Jesús; Zaragozá, Maria Cleofé; Domingo, Joan Carles; Martinez-Martinez, Alba; Alegre, José; von Schacky, Clemens (December 2018). "Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis". Prostaglandins, Leukotrienes and Essential Fatty Acids. 139: 20–24. doi:10.1016/j.plefa.2018.11.006. ISSN 0952-3278.
  20. ↑ Castro-Marrero, Jesús; Faro, Mónica; Zaragozá, María Cleofé; Aliste, Luisa; de Sevilla, Tomás Fernández; Alegre, José (December 2019). "Unemployment and work disability in individuals with chronic fatigue syndrome/myalgic encephalomyelitis: a community-based cross-sectional study from Spain". BMC Public Health. 19 (1). doi:10.1186/s12889-019-7225-z. ISSN 1471-2458. PMC 6599355. PMID 31253111.
  21. ↑ Escorihuela, Rosa María; Capdevila, Lluís; Castro, Juan Ramos; Zaragozà, María Cleofé; Maurel, Sara; Alegre, José; Castro-Marrero, Jesús (December 2020). "Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis". Journal of Translational Medicine. 18 (1): 4. doi:10.1186/s12967-019-02184-z. ISSN 1479-5876. PMC 6943898. PMID 31906988.
  22. ↑ Cheema, Amanpreet K.; Sarria, Leonor; Bekheit, Mina; Collado, Fanny; Almenar‐Pérez, Eloy; Martín‐Martínez, Eva; Alegre, Jose; Castro‐Marrero, Jesus; Fletcher, Mary A.; Klimas, Nancy; Oltra, Elisa; Nathanson, Lubov (April 14, 2020). "Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS". Journal of Cellular and Molecular Medicine. 00: 1–13. doi:10.1111/jcmm.15260. ISSN 1582-4934. PMID 32291908.
  23. ↑ Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557.
  24. ↑ Giloteaux, Ludovic; O'Neal, Adam; Castro-Marrero, Jesús; Levine, Susan M.; Hanson, Maureen R. (December 2020). "Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study". Journal of Translational Medicine. 18 (1): 387. doi:10.1186/s12967-020-02560-0. ISSN 1479-5876. PMC 7552484.
  25. ↑ Malato, João; Sotzny, Franziska; Bauer, Sandra; Freitag, Helma; Fonseca, André; Grabowska, Anna D; Graça, Luís; Cordeiro, Clara; Nacul, Luís; Lacerda, Eliana M; Castro-Marrero, Jesus; Scheibenbogen, Carmen; Westermeier, Francisco; Sepúlveda, Nuno (March 24, 2021). "The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies". medRxiv. doi:10.1101/2021.03.23.21254175. PMID 33791744.

extracellular vesicle An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

circadian rhythm Physical, mental, and behavioral changes that follow a 24-hour cycle, responding mostly to light and dark. Controlled the brain's hypothalamus. (Learn more: www.nigms.nih.gov)

extracellular vesicle An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

See Diagnostic and Statistical Manual of Mental Disorders.

Diagnostic and Statistical Manual of Mental Disorders (DSM) - A psychiatric reference book published by the American Psychiatric Association, often referred to as "the psychiatrist's Bible". Although the most recent version (DSM-5) purports to be the authoritative guide to the diagnosis of mental disorders, the editors of both previous versions of the manual have heavily criticized the current version due to the climate of secrecy that shrouded the development of the latest version. 69% of the people who worked on DSM-5 reported having ties to the pharmaceutical industry. Dr. Allen Frances, who headed the development of the previous version, warned of dangerous unintended consequences such as new false 'epidemics'. The British Psychological Society criticized DSM-5 diagnoses as "clearly based largely on social norms, with 'symptoms' that all rely on subjective judgements" and expressed a major concern that "clients and the general public are negatively affected by the continued and continuous medicalisation of their natural and normal responses to their experiences". A petition signed by over 13,000 mental health professionals stated that the lowered diagnostic thresholds in DSM-5, combined with entirely subjective criteria based on western social norms, would "lead to inappropriate medical treatment of vulnerable populations". The director of the US National Institute of Mental Health, Dr. Thomas R. Insel, pointed out that the diagnoses in DSM-5 had no scientific validity whatsoever. (Learn more: www.scientificamerican.com)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

(HR) - the number of times the heart beats within a certain time period, usually a minute[1]

heart rate (HR) - the number of times the heart beats within a certain time period, usually a minute

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

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