Coenzyme Q10
Coenzyme Q10 (CoQ10) or ubiquinone is found in the mitochondria and as a component of the electron transport chain plays an important role in aerobic respiration.
Evidence[edit | edit source]
A trial of 50 mg CoQ10 taken with 5mg NADH twice daily for eight weeks found improvements in exercise performance/less exercise intolerance and a less fatigue and improved cognitive function, but those in the placebo group had better sensory and affective pain scores.[1]
Plasma CoQ10 was found to be significantly lower in ME/CFS patients than in normal controls and correlated with symptom severity.[2] A literature review found that CoQ10 was marginally deficient in people with chronic fatigue syndrome.[3]
Ubiquinol-10 supplementation can improve autonomic nervous function and cognitive function in chronic fatigue syndrome.[4]
Notable studies[edit | edit source]
- 2000, Nutritional Strategies for Treating Chronic Fatigue Syndrome[3](Full text)
- 2009, Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder[2](Abstract)
- 2016, Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome[4](Abstract)
- 2016,Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial[1] - (Full text)
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ 1.01.1 Castro-Marrero, Jesus; Sáez-Francàs, Naia; Segundo, María Jose; Calvo, Natalia; Faro, Mónica; Aliste, Luisa; Fernández de Sevilla, Tomás; Alegre, José (August 2016). "Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial". Clinical Nutrition. 35 (4): 826–834. doi:10.1016/j.clnu.2015.07.010. ISSN 0261-5614.
- ↑ 2.02.1 Maes, M; Mihaylova, I; Kubera, M; Uytterhoeven, M; Vrydags, N; Bosmans, E (2009), "Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder", Neuro Endocrinology Letters, 30 (4): 470–476, PMID 20010505
- ↑ 3.03.1 Werbach, Melvyn R. (May 2000). "Nutritional Strategies for Treating Chronic Fatigue Syndrome" (PDF). Alternative Medicine Review. 5 (2): 93–108.
- ↑ 4.04.1 Fukuda, S; Nojima, J; Kajimoto, O; Yamaguti, K; Nakatomi, Y; Kuratsune, H; Watanabe, Y (April 29, 2016), "Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome", BioFactors (Oxford, England), doi:10.1002/biof.1293, PMID 27125909
coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.
coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.
coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.
coenzyme Q10 (CoQ10) - Coenzyme Q10 (also known as ubiquinone) is found in the mitochondria and, as a component of the electron transport chain, plays an important role in aerobic respiration. The chemically-reduced form of CoQ10 is called ubiquinol.
double blinded trial A clinical trial is double blinded if neither the participants nor the researchers know which treatment group they are allocated to until after the results are interpreted. This reduces bias. (Learn more: www.nottingham.ac.uk)
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