Lorenzo Lorusso

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Lorenzo Lorusso, MD, is the Head of the Multiple Sclerosis (SM)/Amyotrophic Lateral Sclerosis (ALS) Centre and a Consultant Neurologist at Mellino Mellini Hospital, Chiari-Brescia, Italy. He serves on the Scientific Committee of Associazione Malati di CFS onlus, a patient advocacy group for chronic fatigue syndrome in Pavia, Italy and on the scientific committee for creating recommendations for the Italian National Agency for Health Regional Service (AGENAS) of the Italian National Institute of Health on CFS/ME.

EUROMENE[edit | edit source]

Dr. Lorusso is a member of the Working Group on dissemination and exploitation, patient involvement, digitalisation on behalf of the EUROMENE, a European Union COST Action CA15111 not-for-profit research organization committed to tackling the cause and treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[1]

Notable studies[edit | edit source]

  • 2004, Chronic fatigue syndrome: a review[2] - (Abstract)
  • 2006, A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles[3] - (Full text)
  • 2009, Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome[4] - (Abstract)
  • 2009, Immunological aspects of chronic fatigue syndrome[5] - (Abstract)
  • 2010, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An Update[6] - (Full Text)
  • 2015, Chronic fatigue syndrome: Features of a population of patients from northern Italy[7] - (Full Text)
  • 2016, Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome[8] - (Full Text)
  • 2017, XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable[9] - (Full Text)
  • 2018, Cardiovascular characteristics of chronic fatigue syndrome[10] - (Full Text)
  • 2018, Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review[11] -?(Full text)
  • 2020, Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology [12] - (Full text)
  • 2021, Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME)[13] - (Full text)
  • 2021, European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe[14] - (Full text)
  • 2022, Systematic review and meta‐analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[15] - (Full text)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ http://www.cost.eu/COST_Actions/ca/CA15111?management
  2. ↑ Carlo-Stella, N; Lorusso, L; Candura, SM; Cuccia, M (2004). "Chronic fatigue syndrome: a review". Recenti Prog Med. 96 (11): 546-52. PMID 15598093.
  3. ↑ Carlo-Stella, N; Badulli, C; De Silvestri, A; Bazzichi, L; Martinetti, M; Lorusso, L; Bombardieri, S; Salvaneschi, L; Cuccia, M (2006). "A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles". Clinical and Experimental Rheumatology. 24 (2): 179-82. PMID 16762155.
  4. ↑ Carlo-Stella, N; Bozzini, S; De Silvestri, A; Sbarsi, I; Pizzochero, C; Lorusso, L; Martinetti, M; Cuccia, M (2009). "Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome". International Journal of Immunopathology and Pharmacology. 22 (3): 745-54. doi:10.1177/039463200902200320. PMID 19822091.
  5. ↑ Lorusso, Lorenzo; Mikhaylova, SV; Capelli, Enrica; Ferrari, D; Ngonga, GK; Ricevuti, Giovanni (2009). "Immunological aspects of chronic fatigue syndrome". Autoimmun Rev. 8 (4): 287-91. doi:10.1016/j.autrev.2008.08.003. PMID 18801465.
  6. ↑ Capelli, Enrica; Zola, R; Lorusso, Lorenzo; Venturini, Luigi; Sardi, F; Ricevuti, Giovanni (2010). "Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An Update". International Journal of Immunopathology and Pharmacology. 23 (4): 981-989. doi:10.1177/039463201002300402. PMID 21244747.
  7. ↑ Capelli, Enrica; Lorusso, Lorenzo; Ghitti, M; Venturini, Luigi; Cusa, C; Ricevuti, Giovanni (2015), "Chronic fatigue syndrome: Features of a population of patients from northern Italy", International Journal of Immunopathology and Pharmacology, doi:10.1177/0394632015572074
  8. ↑ Maltese, PE; Venturini, L; Poplavskaya, E; Bertelli, M; Cecchin, S; Granato, M; Nikulina, SY; Salmina, A; Aksyutina, N; Capelli, Enrica; Ricevuti, Giovanni; Lorusso, Lorenzo (2016). "Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome". Genet Mol Res. 15 (3). doi:10.4238/gmr.15038717.
  9. ↑ Panelli, Simona; Lorusso, Lorenzo; Balestrieri, Alessandro; Lupo, Giuseppe; Capelli, Enrica (2017). "XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR, and Its Association with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Appears Unreliable". Frontiers in Public Health. 5 (108). doi:10.3389/fpubh.2017.00108. PMC 5439170. PMID 28589117.
  10. ↑ Bozzini, S; Albergati, A; Capelli, Enrica; Lorusso, L; Gazzaruso, C; Pelissero, G; Falcone, C (2018). "Cardiovascular characteristics of chronic fatigue syndrome". Biomedical Reports. 8 (1): 26–30. doi:10.3892/br.2017.1024. PMC 5772628. PMID 29399336.
  11. ↑ Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (September 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183.
  12. ↑ Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557.
  13. ↑ Lupo, Giuseppe Francesco Damiano; Rocchetti, Gabriele; Lucini, Luigi; Lorusso, Lorenzo; Manara, Elena; Bertelli, Matteo; Puglisi, Edoardo; Capelli, Enrica (March 2021). "Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME)". Scientific Reports. 11 (1): 7043. doi:10.1038/s41598-021-86425-6. ISSN 2045-2322. PMID 33782445.
  14. ↑ Nacul, Luis; Authier, François Jérôme; Scheibenbogen, Carmen; Lorusso, Lorenzo; Helland, Ingrid Bergliot; Martin, Jose Alegre; Sirbu, Carmen Adella; Mengshoel, Anne Marit; Polo, Olli; Behrends, Uta; Nielsen, Henrik; Grabowski, Patricia; Sekulic, Slobodan; Sepulveda, Nuno; Estévez-López, Fernando; Zalewski, Pawel; Pheby, Derek F.H.; Castro-Marrero, Jesus; Sakkas, Giorgos K.; Capelli, Enrica; Brundsdlund, Ivan; Cullinan, John; Krumina, Angelika; Bergquist, Jonas; Murovska, Modra; Vermuelen, Ruud C.W.; Lacerda, Eliana M. (May 2021). (EUROMENE). "European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe". Medicina. 57 (5): 510. doi:10.3390/medicina57050510. PMC 8161074. PMID 34069603.
  15. ↑ Aoun Sebaiti, Mehdi; Hainselin, Mathieu; Gounden, Yannick; Sirbu, Carmen Adella; Sekulic, Slobodan; Lorusso, Lorenzo; Nacul, Luis; Authier, François Jérôme (February 9, 2022). "Systematic review and meta-analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Scientific Reports. 12 (1): 2157. doi:10.1038/s41598-021-04764-w. ISSN 2045-2322. PMC 8828740. PMID 35140252.

See ME/CFS.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

human leukocyte antigen complex (HLA) - A set of genes responsible for a given person's immune response to potential threats. Specifically, HLA genes encode proteins which help the immune system to distinguish the body's own proteins from proteins which are made by foreign invaders like bacteria and viruses. The HLA complex can vary greatly from person to person, generating unique immune and allergic responses. (Learn more: mecfsresearchreview.me)

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

genome an organism's complete set of DNA, including all of its genes

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

cognition Thought processes, including attention, reasoning, and memory.

The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

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