Human leukocyte antigen complex
The Human Leukocyte Antigen complex or HLA complex is a group of proteins that "helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria". It is the human version of the Major Histocompatibility Complex (MHC), which is also found in certain non-human species.
Autoimmune disease[edit | edit source]
HLA associations in the genes of patients are considered to be a classic indicator that is a disease is autoimmune disease in nature.
ME/CFS[edit | edit source]
A number of different studies by Mella et al. in Norway have found associations between HLA genes and ME/CFS patients meeting the Canadian Consensus Criteria, suggesting ME/CFS may be an autoimmune illness.
See also[edit | edit source]
Learn more[edit | edit source]
- Histocompatibility complex - Genetics home reference - US Library of Medicine
References[edit | edit source]
- "Genetics". MedlinePlus. Retrieved November 8, 2021.
- "Definition of HUMAN LEUKOCYTE ANTIGEN". Merriam-Webster Dictionary. Retrieved November 8, 2021.
- Hajdarevic, Riad; Lande, Asgeir; Rekeland, Ingrid; Rydland, Anne; Strand, Elin B.; Sosa, DaisyD.; Creary, Lisa E; Mella, Olav; Egeland, Torstein (November 1, 2021). "Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci". Brain, Behavior, and Immunity. 98: 101–109. doi:10.1016/j.bbi.2021.08.219. ISSN 0889-1591.