Leorey N. Saligan, Ph.D., R.N., C.R.N.P., is a Assistant Clinical Investigator in the National Institute of Nursing Research (NINR) of the United States National Institutes of Health.
His research interests center around fatigue, particularly fatigue experienced by cancer patients as a result of his parents both being diagnosed with cancer. He has developed an exercise intervention geared to improve aerobic metabolism of patients in order to potentially reduce oxidative stress, inflammation, and fatigue.
Controversy[edit | edit source]
In a very small uncontrolled study (n = 9) exploring the relationship between gene expression and pain catastrophizing in fibromyalgia, Saligan and his co-authors used a score of 16 on the Pain Catastrophizing Scale as the threshold for determination of "high catastrophizing". That is in stark contrast with the threshold of 30 recommended by the scale's creators to indicate a "clinically relevant level of catastrophizing," and a mean score for 851 injured workers was 20.90. Even the high catastrophizing subgroup (n = 5) in the study averaged a pain catastrophizing score of only 23.6, well below the recommended threshold. The authors concluded that "specific physiological pathways may possibly delineate pain and catastrophizing mechanisms."
ME/CFS Common Data Element (CDE) Project[edit | edit source]
Member on both the Fatigue Working Group and the Pain Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.
Notable studies[edit | edit source]
- 2017, Public Review - Draft of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials - (Full Text)
- 2016, Different Phenotyping Approaches Lead to Dissimilar Biologic Profiles in Men With Chronic Fatigue After Radiation Therapy
Editorial[edit | edit source]
- Editorial - Understanding cancer-related fatigue: advancing the science, Full text by Michael Renner and Leorey N. Saligan
Talks and interviews[edit | edit source]
- 2015, Is Medical Research for You? Meet Leorey Saligan, principal investigator in the Symptom Management Branch at the National Institutes of Health. Leorey’s research involves looking at blood samples from patients who have undergone cancer therapy and contributes to figuring out why cancer treatments cause fatigue
Online presence[edit | edit source]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- https://www.cdc.gov/cdcgrandrounds/pdf/archives/2016/feb2016.pdf page 54
- "Fatigue: Biomedicine, Health & Behavior". www.tandfonline.com. Retrieved Nov 1, 2019.
- Gene expression profiles of fatigued fibromyalgia patients with different categories of pain and catastrophizing: A preliminary report
- The Pain Catastrophizing Scale: User Manual
- "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019.
- Cella, David; Dimmock, Mary; Friedberg, Fred; Lin, Jin-Mann Sally; Nacul, Luis; Saligan, Leorey (Dec 2017), NINDS/CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials (PDF)
- Feng LR, Dickinson K, Kline N, Saligan LN. Different phenotyping approaches lead to dissimilar biologic profiles in men with chronic fatigue following radiation therapy Exit Disclaimer. J Pain Symptom Manage. 2016 Aug 9. pii: S0885-3924(16)30225-1. PMID: 27521284
- Renner, Michael; Saligan, Leorey N. (2016), "Understanding cancer-related fatigue: advancing the science", Fatigue: Biomedicine, Health & Behavior, 4 (4): 189-192, doi:10.1080/21641846.2016.1246513
National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.