James Baraniuk

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Source:www.prohealth.com

James Nicholas Baraniuk, MD, is an Associate Professor with Tenure in the Department of Medicine at Georgetown University[1] and the Director of the Chronic Pain and Fatigue Research Center, located within the Georgetown University Medical Center in Washington,D.C. The Chronic Pain and Fatigue Research Center does research on chronic fatigue syndrome (CFS), Gulf War Illness (GWI) and other pain conditions, particularly in the areas of Functional Magnetic Resonance Imaging (fMRI), biomarker discovery through proteomic, metabolomic, and transcriptomic assays in blood and cereobrospinal fluid, autonomic testing and heart rate variability (HRV) and statistical analyses using machine learning, hierarchical clustering, and other data mining methods.[2]

Education[edit | edit source]

  • 1972-1976 - B. Sc. (Hons.), Joint Honours in Chemistry and Microbiology, Dean's Honour List, University of Manitoba, Winnipeg, Manitoba, Canada
  • 1977-1981 - M.D., University of Manitoba
  • 1978-1979 - B. Sc. (Medicine), University of Manitoba
  • 1981-1982 - Internship, Saint Thomas Hospital Medical Center, Akron, Ohio
  • 1982-1984 - Internal Medicine Resident, Saint Thomas Hospital Medical Center, Akron, Ohio
  • 1984-1985 - Senior Assistant Resident in Internal Medicine, Duke University Medical Center, Durham, North Carolina
  • 1985-1987 - Fellowship in Allergy and Clinical Immunology, Duke University Medical Center

Positions of employment[edit | edit source]

  • 1987-1989 - Adjunct Scientist, Allergy Disease Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD
  • 1989-1991 - Visiting Clinical Scientist, Thoracic Medicine Department, National Heart and Lung Institute, London, England
  • 1991-present - Department of Medicine, Georgetown University, Washington,D.C.

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Neurologic/Cognitive/CNS Imaging Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke (NINDS) and the Centers for Disease Control and Prevention (CDC).[3]

Physician guide[edit | edit source]

  • 2018 - Authored the update to BMJ Best Practice: Chronic fatigue syndrome/Myalgic encephalomyelitis[4]

Notable studies related to ME/CFS[edit | edit source]

  • 1998, IgE Concentrations in Chronic Fatigue Syndrome[5]
  • 2000, Irritant Rhinitis in Allergic, Nonallergic, Control and Chronic Fatigue Syndrome Populations[6]
  • 2000, Tobacco Sensitivity in Chronic Fatigue Syndrome (CFS)[7] - (Abstract)
  • 2002, Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects[8] - (Abstract)
  • 2002, Cytokines in nasal lavage fluids from acute sinusitis, allergic rhinitis, and chronic fatigue syndrome subjects.[9] - (Abstract)
  • 2005, A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.[10] - (Full Text)
  • 2010, Xenotropic Murine Leukemia Virus-Related Virus in Chronic Fatigue Syndrome and Prostate Cancer[11] - (Full Text)
  • 2011, Migraine headaches in chronic fatigue syndrome (CFS): comparison of two prospective cross-sectional studies.[12]
  • 2012, No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome[13] - (Full text)
  • 2012, Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies.[14] - (Full Text)
  • 2013, Increased Brain White Matter Axial Diffusivity Associated with Fatigue, Pain and Hyperalgesia in Gulf War Illness[15] - (Full Text)
  • 2013, Migraine in gulf war illness and chronic fatigue syndrome: Prevalence, potential mechanisms, and evaluation.[16] - (Full Text)
  • 2013, A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria[17] - (Full Text)
  • 2017, Chronic Fatigue Syndrome prevalence is grossly overestimated using Oxford criteria compared to Centers for Disease Control (Fukuda) criteria in a U.S. population study[18](Full text)
  • 2017, Exercise-induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects[19] - (Full Text) (Author Correction)[20]
  • 2019, Chronic fatigue syndrome in the emergency department[21] - (Full text)
  • 2019, Orthostatic intolerance in chronic fatigue syndrome[22] - (Full text)
  • 2020, A Machine Learning Approach to the Differentiation of Functional Magnetic Resonance Imaging Data of Chronic Fatigue Syndrome (CFS) From a Sedentary Control[23] - (Full text)
  • 2020, Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[24] - (Full text)
  • 2022, Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM)[25] - (Full text)

Talks and interviews[edit | edit source]

Advocacy[edit | edit source]

Open letter to The Lancet[edit | edit source]

Dr Baraniuk signed two open letters to the editor of The Lancet urging the editor to commission a fully independent review of the PACE trial, which the journal published in 2011.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ "Georgetown University Faculty Directory". gufaculty360.georgetown.edu. Retrieved March 3, 2020.
  2. ↑ "Chronic Pain and Fatigue Research Center". sites.google.com. Retrieved March 3, 2020.
  3. ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
  4. ↑ "Chronic fatigue syndrome/Myalgic encephalomyelitis - Symptoms, diagnosis and treatment | BMJ Best Practice". bestpractice.bmj.com. Retrieved September 14, 2018.
  5. ↑ Baraniuk, James N.; Clauw, Daniel; Macdowellcarneiro, Anna-Louisa; Bellanti, Joseph; Pandiri, Pavani; Foong, Sukmun; Ali, Mushtaq (January 1998). "IgE Concentrations in Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome. 4 (1): 13–21. doi:10.1300/j092v04n01_03. ISSN 1057-3321.
  6. ↑ Baraniuk, James N.; Naranch, Kristina; Maibach, Hilda; Clauw, Daniel J. (2000), "Irritant Rhinitis in Allergic, Nonallergic, Control and Chronic Fatigue Syndrome Populations", Journal of Chronic Fatigue Syndrome, 7 (2): 3-31, doi:10.1300/J092v07n02_02
  7. ↑ Baraniuk, James N.; Naranch, Kristina; Maibach, Hilda; Clauw, Daniel J. (2000), "Tobacco Sensitivity in Chronic Fatigue Syndrome (CFS)", Journal of Chronic Fatigue Syndrome, 7 (2): 33-52, doi:10.1300/J092v07n02_03
  8. ↑ Naranch, K.; Repka-Ramirez, S.M.; Park, Y.-J.; Velarde, A.; Finnegan, R.; Murray, J.; Pheiffer, A.; Hwang, E.; Clauw, D.; Baraniuk, James (January 2002). "Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects". Journal of Chronic Fatigue Syndrome. 10 (1): 3–15. doi:10.1300/J092v10n01_02. ISSN 1057-3321.
  9. ↑ Repka-Ramirez, Susana; Naranch, Kristina; Park, Yong-Jin; Clauw, Daniel; Baraniuk, James N. (May 2002). "Cytokines in nasal lavage fluids from acute sinusitis, allergic rhinitis, and chronic fatigue syndrome subjects". Allergy and Asthma Proceedings. 23 (3): 185–190. ISSN 1088-5412. PMID 12125506.
  10. ↑ Baraniuk, J.N.; Casado, B.; Maibach, H.; Clauw, D.H.; Pannell, L.K.; Hess, S.A. (2005), "Chronic fatigue syndrome – related proteome in human cerebrospinal fluid", BMC Neurology, 5 (22), doi:10.1186/1471-2377-5-22
  11. ↑ Baraniuk, James N. (May 2010). "Xenotropic Murine Leukemia Virus-Related Virus in Chronic Fatigue Syndrome and Prostate Cancer". Current Allergy and Asthma Reports. 10 (3): 210–214. doi:10.1007/s11882-010-0106-2. ISSN 1529-7322. PMC 2880572. PMID 20425007.
  12. ↑ Ravindran, Murugan K; Zheng, Yin; Timbol, Christian; Merck, Samantha J; Baraniuk, James N (March 5, 2011). "Migraine headaches in Chronic Fatigue Syndrome (CFS): Comparison of two prospective cross-sectional studies". BMC Neurology. 11 (1). doi:10.1186/1471-2377-11-30. ISSN 1471-2377. PMID 21375763.
  13. ↑ Burbelo, PeterD.; Bayat, Ahmad; Wagner, Jason; Nutman, Thomas B.; Baraniuk, James N.; Iadarola, Michael J. (2012). "No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome". American Journal of Translational Research. 4 (4): 443–451. ISSN 1943-8141. PMC 3493030. PMID 23145212.
  14. ↑ Ravindran, Murugan; Adewuyi, Oluwatoyin; Zheng, Yin; Rayhan, Rakib U.; Le, Uyenphuong; Timbol, Christian; Merck, Samantha; Esteitie, Rania; Read, Charles; Baraniuk, James (December 12, 2012). "Dyspnea in Chronic Fatigue Syndrome (CFS): Comparison of Two Prospective Cross-Sectional Studies". Global Journal of Health Science. 5 (2). doi:10.5539/gjhs.v5n2p94. ISSN 1916-9744.
  15. ↑ Rayhan, Rakib U.; Stevens, Benson W.; Timbol, Christian R.; Adewuyi, Oluwatoyin; Walitt, Brian; VanMeter, John W.; Baraniuk, James N. (March 20, 2013). Zang, Yu-Feng (ed.). "Increased Brain White Matter Axial Diffusivity Associated with Fatigue, Pain and Hyperalgesia in Gulf War Illness". PLoS ONE. 8 (3): e58493. doi:10.1371/journal.pone.0058493. ISSN 1932-6203. PMC 3603990. PMID 23526988.
  16. ↑ Rayhan, Rakib U.; Ravindran, Murugan K.; Baraniuk, James N. (2013). "Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation". Frontiers in Physiology. 4. doi:10.3389/fphys.2013.00181. ISSN 1664-042X.
  17. ↑ Baraniuk, James N.; Adewuyi, Oluwatoyin; Merck, Samantha Jean; Ali, Mushtaq; Ravindran, Murugan K.; Timbol, Christian R.; Rayhan, Rakib; Zheng, Yin; Le, Uyenphuong (2013). "A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria". American Journal of Translational Research. 5 (1): 53–68. ISSN 1943-8141. PMC 3560481. PMID 23390566.
  18. ↑ Baraniuk, James N. (October 2, 2017). "Chronic fatigue syndrome prevalence is grossly overestimated using Oxford criteria compared to Centers for Disease Control (Fukuda) criteria in a U.S. population study". Fatigue: Biomedicine, Health & Behavior. 5 (4): 215–230. doi:10.1080/21641846.2017.1353578. ISSN 2164-1846. PMC 6407870. PMID 30854252.
  19. ↑ Baraniuk, J.N.; Shivapurkar, N. (2017), "Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects", Scientific Reports, 7 (15338), doi:10.1038/s41598-017-15383-9
  20. ↑ Baraniuk, James N.; Shivapurkar, Narayan (April 19, 2018). "Author Correction: Exercise – induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects". Scientific Reports. 8 (1). doi:10.1038/s41598-018-23238-0. ISSN 2045-2322. PMID 29674668.
  21. ↑ Baraniuk, James N.; Timbol, Christian R. (January 11, 2019). "Chronic fatigue syndrome in the emergency department". Open Access Emergency Medicine. doi:10.2147/oaem.s176843. Retrieved January 19, 2019.
  22. ↑ Garner, Richard; Baraniuk, James N. (December 2019). "Orthostatic intolerance in chronic fatigue syndrome". Journal of Translational Medicine. 17 (1). doi:10.1186/s12967-019-1935-y. ISSN 1479-5876.
  23. ↑ Provenzano, Destie; Washington, StuartD.; Baraniuk, James N. (January 29, 2020). "A Machine Learning Approach to the Differentiation of Functional Magnetic Resonance Imaging Data of Chronic Fatigue Syndrome (CFS) From a Sedentary Control". Frontiers in Computational Neuroscience. 14: 2. doi:10.3389/fncom.2020.00002. ISSN 1662-5188.
  24. ↑ Washington, StuartD.; Rayhan, Rakib U.; Garner, Richard; Provenzano, Destie; Zajur, Kristina; Addiego, Florencia Martinez; VanMeter, John W.; Baraniuk, James N. (July 1, 2020). "Exercise alters brain activation in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Brain Communications. 2 (2). doi:10.1093/braincomms/fcaa070.
  25. ↑ Baraniuk, James N. (February 2022). "Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM)". Brain Sciences. 12 (2): 132. doi:10.3390/brainsci12020132. ISSN 2076-3425. PMC 8870178. PMID 35203896.
  26. ↑ "IIMEC6 International ME Conference 2011". Invest in ME Research. Retrieved March 3, 2020.
  27. ↑ "IIMEC7 International ME Conference 2012". Invest in ME Research. Retrieved March 3, 2020.
  28. ↑ "IIMEC9 International ME Conference 2014". Invest in ME Research. Retrieved March 3, 2020.
  29. ↑ "IIMEC11 International ME Conference 2016". Invest in ME Research. Retrieved March 3, 2020.
  30. ↑ "IIMEC13 International ME Conference 2018". Invest in ME Research. Retrieved March 3, 2020.
  31. ↑ "IIMEC14 14th Invest in ME Reseaerch International ME Conference 2019". Invest in ME Research. Retrieved March 3, 2020.
  32. ↑ Tuller, David (February 10, 2016). "An open letter to The Lancet, again".
  33. ↑ Tuller, David (June 19, 2018). "Trial By Error: An Open Letter to The Lancet, Two Years On".

assay 1. (verb) analysis (as of an ore or drug) to determine the presence, absence, or quantity of one or more components. 2. (noun) In biochemistry, any laboratory protocol used to test a sample for one or more qualities.

heart rate variability (HRV) - A measurement of the variability of the heart rate over time. When the heart rate is consistent, there will be a low heart rate variability. When the heart rate is constantly changing, there will be a high heart rate variability. Heart rate variability is often used by ME/CFS patients to monitor their autonomic nervous system, as high heart rate variability is associated with the sympathetic nervous system and low heart rate variability is associated with the parasympathetic nervous system.

cognition Thought processes, including attention, reasoning, and memory.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

tachycardia An unusually rapid heart beat. Can be caused by exercise or illness. A symptom of postural orthostatic tachycardia syndrome (POTS). (Learn more: www.heart.org)

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.

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