Ronald Davis
Ronald Wayne Davis, PhD., is a Professor of Biochemistry & Genetics and the Director of the Stanford Genome Technology Center at Stanford University. In 1983, he was bestowed the honor of being elected a member of the National Academy of Sciences.[1]
His son, Whitney Dafoe, is severely ill with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Professor Davis leads the End ME/CFS Project with the Open Medicine Foundation whose first project was the ME/CFS Severely Ill, Big Data Study.[2]
Contents
Committees and boards[edit | edit source]
Open Medicine Foundation[edit | edit source]
Director of the Scientific Advisory Board at Open Medicine Foundation, which is committed to research for ME/CFS and related chronic complex diseases.[3]
Institute of Medicine report[edit | edit source]
Dr. Davis was one of the experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened as per US government request for the 2015 Institute of Medicine.[4] The Institute of Medicine has since changed its name to the National Academy of Medicine.[5]
ME/CFS Common Data Element (CDE) Project[edit | edit source]
Member of the Biomarkers Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[6]
Advocacy[edit | edit source]
Open Letters[edit | edit source]
- 2016 and 2018, Dr. Davis was one of the signatories of the Open letter to the Lancet urging its editor to commission a fully independent review of the PACE trial as published in its journal.[7][8][9]
- 2017, Dr. Davis was one of the signatories of An open letter to Psychological Medicine about “recovery” and the PACE trial[10]
Millions Missing protest[edit | edit source]
Dr. Ron Davis and his wife, Dr. Janet Dafoe, protested with #MillionsMissing at the San Francisco satellite protest on May 25, 2016.[11] Dr. Davis gave a speech about the challenges ME patients face, and his hopes for the future of ME research.[12] To see video of Dr. Davis's interview at the San Francisco #MillionsMissing click HERE.
ME/CFS research[edit | edit source]
- March 2016, it was announced that the ME/CFS Severely Ill, Big Data Study had a significant result in the area of mitochondria. This lead to the addition of Dr. Robert Naviaux (a mitochondrial expert) to the research team.[13]
- February 2017, Dr. Davis explained in a video that the development of new nanofabricated technology allows rapid drug screening via measurement of electrical impedance. This technology may be able to determine which medications could be most effective in treating myalgic encephalomyelitis/chronic fatigue syndrome. Experimentation is also being carried out to test if this same nanofabricated technology could be used in developing a simple diagnostic test for myalgic encephalomyelitis/chronic fatigue syndrome.[14]
- June 2018, Dr. Davis and the Stanford Genome Center received a grant award for the research study 'Molecular and Single-cell Immunology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome' "to investigate the immunological basis of ME/CFS using cutting-edge technologies to understand the role of infection and autoimmunity in the behavior of single immune cells from patients – offering precise insights into how this complex illness originates and persists that may lead to new strategies for treatment."[15] This is a five-year study that will receive $745,000 a year.[16]
- Nov 2018, Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome[17]
- Feb 2019, Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome[18] - (Full text)
- Apr 2019, A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[19] - (Full text)
Talks and interviews[edit | edit source]
2016
- 21 May 2016, Short Story of a Family's Struggle with ME/CFS[20]
- 3 Jun 2016, Speaker at the 11th Invest in ME International ME Conference - Big Data Approach: Severely Ill ME Patient Cohort DVD available
- 13 Dec 2016, Getting Answers to ME/CFS Faster through Collaboration and Openness[21]
2017
- 3 Feb 2017, Scientist Ron Davis Tells How We Are "Fast-Tracking" ME/CFS Research[22]
- 20 Feb 2017, Chronic Fatigue: Missing Millions (Carte Blanche DSTV)
- 21 Feb 2017, "An Update on ME/CFS Research with Dr. Ronald W. Davis"
- 7 Mar 2017, Q&A on ME/CFS Research with Dr. Ron Davis[23]
- Jun, Ron Davis is optimistic at the 2017 Invest in ME Research Conference[24]
- 2 Jun 2017, Speaker at the 12th Invest in ME International ME Conference on "Big Data Approach: Severely ill ME Patient Cohort"[25]DVD available
- 15 Jun 2017, "The Last Major Disease To Be Studied? Ron Davis of Stanford Thinks So"
- 12 Aug 2017, Community Symposium on the Molecular Basis of ME/CFS - 2017: Speech title - Establishing new mechanistic and diagnostic paradigms for ME/CFS[26]
2018
- 3-5 May 2018, ME/CFS Canadian Collaborative Team Conference - Speech titles: The Future of ME/CFS Research in the Multiomic and Big Data Era and An Integrative, Molecular, Data and Technology-Driven Approach to ME/CFS[27]
- 3 Jun 2018, Speaker at the 13th Invest in ME Conference 2018; Speech title: Establishing new mechanistic and diagnostic paradigms for ME/CFS[28]- (Video)
- Sep 2018, Dr. Ron Davis Presents ME/CFS Research at the 2018 IIMEC Conference[29] Patients' gene expression profiles most closely resembles Trypanosome infection (African sleeping sickness) variant suspected.
- 29 Sep 2018, Biomarkers, given at Second Annual Community Symposium on the Molecular Basis of ME/CFS, sponsored by Open Medicine Foundation - (Video)
2019
- 14 Mar 2019, Establishing New Mechanistic & Diagnostic Paradigms for ME/CFS given at the International Research Symposium, Geelong, Australia, sponsored by Emerge Australia
- 29 Apr 2019, What does the nanoneedle research mean for ME/CFS patients?
- 31 May 2019, Speaker at the 14th Invest in ME International ME Conference; Speech title: Establishing new mechanistic and diagnostic paradigms for ME/CFS - (Video)
- 8 June 2019, Stanford Experiences with ME/CFS: Update on Stanford activities, given at the Inaugural Harvard ME/CFS Collaboration Symposium sponsored by Open Medicine Foundation
Online presence[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
- Wikipedia - Ronald Davis
- 2016, Happy 75th Birthday to Scientist Ronald W. Davis, PhD[30]
- 2016, Tackling chronic fatigue syndrome[31]
- 2016, The puzzle solver: A researcher changes course to help his son[32]
References[edit | edit source]
- ↑ http://www.nasonline.org, National Academy of Sciences -. "Ronald Davis". www.nasonline.org. Retrieved Aug 16, 2018.
- ↑ "End ME/CFS Project | Open Medicine Foundation". Open Medicine Foundation. Retrieved Aug 16, 2018.
- ↑ "Scientific Advisory Board | Open Medicine Foundation". Open Medicine Foundation. Retrieved Aug 16, 2018.
- ↑ Syndrome, Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue; Populations, Board on the Health of Select; Medicine, Institute of (Feb 10, 2015). Biographical Sketches of Committee Members, Consultants, and Staff. National Academies Press (US).
- ↑ "Home - National Academy of Medicine". National Academy of Medicine. Retrieved Aug 16, 2018.
- ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019.
- ↑ "An open letter to Dr. Richard Horton and The Lancet". www.virology.ws. Retrieved Aug 18, 2018.
- ↑ "An open letter to The Lancet, again". www.virology.ws. Retrieved Aug 18, 2018.
- ↑ "Trial By Error: An Open Letter to The Lancet, Two Years On". www.virology.ws. Retrieved Aug 18, 2018.
- ↑ "An open letter to Psychological Medicine about "recovery" and the PACE trial". www.virology.ws. Retrieved Aug 18, 2018.
- ↑ "#MillionsMissing - #MillionsMissing". millionsmissing.meaction.net. Retrieved Aug 16, 2018.
- ↑ "Speeches from the Front Lines of #MillionsMissing: Ron Davis | #MEAction". www.meaction.net. Retrieved Aug 16, 2018.
- ↑ "End ME/CFS Severe Patient Study Turns to the Mitochondria". Health Rising's Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Forums. Retrieved Sep 12, 2019.
- ↑ An Update on ME/CFS Research with Dr. Ronald W. Davis, retrieved Sep 12, 2019
- ↑ Molecular and Single-cell Immunology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - NIH RePORT Project Number 1R01AI139550-01
- ↑ HealthRising: Ron Davis (Finally) Gets His Big Grant! by Cort Johnson via Open Medicine Foundation
- ↑ Saha, Amit K; Schmidt, Brendan R; Wilhelmy, Julie; Nguyen, Vy; Do, Justin; Suja, Vineeth C; Nemat-Gorgani, Mohsen; Ramasubramanian, Anand K; Davis, Ronald W (Nov 2018). "Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome". Blood (132): 4874. doi:10.1182/blood-2018-99-117260.
- ↑ Saha, Amit K.; Schmidt, Brendan R.; Wilhelmy, Julie; Nguyen, Vy; Abugherir, Abed; Do, Justin K.; Nemat-Gorgani, Mohsen; Davis, Ronald W.; Ramasubramanian, Anand K. (Feb 23, 2019). "Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome". Clinical Hemorheology and Microcirculation. 71 (1): 113–116. doi:10.3233/CH-180469.
- ↑ Esfandyarpour, R.; Kashi, A.; Nemat-Gorgani, M.; Wilhelmy, J.; Davis, R. W. (May 21, 2019). "A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Proceedings of the National Academy of Sciences. 116 (21): 10250–10257. doi:10.1073/pnas.1901274116. ISSN 0027-8424.
- ↑ Davis Family (May 21, 2016). "Short Story of a Family's Struggle with ME/CFS". YouTube.
- ↑ Davis, Ronald; Tannenbaum, Linda (Dec 13, 2016). "Getting Answers to ME/CFS Faster through Collaboration and Openness". YouTube. Open Medicine Foundation - OMF.
- ↑ Davis, Ronald (Feb 3, 2017). "Scientist Ron Davis Tells How We Are "Fast-Tracking" ME/CFS Research". YouTube. Open Medicine Foundation - OMF.
- ↑ Davis, Ronald (Mar 7, 2017). "Q&A on ME/CFS Research with Dr. Ron Davis". YouTube. Open Medicine Foundation - OMF.
- ↑ Davis, Ronald (Jun 20, 2017). "Ron Davis is optimistic at the 2017 Invest in ME Research Conference". YouTube. Open Medicine Foundation - OMF.
- ↑ "Invest in ME Research - International ME Conferences and Colloquiums Home Page". investinme.org. Retrieved Sep 12, 2019.
- ↑ Davis, Ronald (Sep 28, 2017). "Ronald Davis, PhD, Speaking on ME/CFS Research Approach". YouTube. Open Medicine Foundation - OMF.
- ↑ "ME/CFS Canadian Collaborative Team Conference program" (PDF). Retrieved Mar 6, 2019.
- ↑ "Invest in ME Research - IIMEC13 International ME Conference 2018". www.investinme.org. Retrieved Feb 26, 2020.
- ↑ Davis, Ronald (Sep 17, 2018). "Dr. Ron Davis Presents ME/CFS Research at the 2018 IIMEC Conference". YouTube. Open Medicine Foundation - OMF.
- ↑ Davis, Ronald (Jul 12, 2016). "Happy 75th Birthday to Scientist Ronald W. Davis, PhD". YouTube. Open Medicine Foundation - OMF.
- ↑ Gu, Katie (Jan 4, 2016). "Tackling Chronic Fatigue Syndrome". The Stanford Daily. Retrieved Sep 17, 2018.
- ↑ White, Tracie. "The puzzle solver". Stanford Medicine. Retrieved Sep 17, 2018.
genome - an organism’s complete set of DNA, including all of its genes
Institute of Medicine report (IOM report) - A report that was commissioned by the U.S. government and was published by the Institute of Medicine on February 10, 2015. The report was titled "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness" and proposed the term Systemic Exertion Intolerance Disease (SEID). Among its key findings were that "This disease is characterized by profound fatigue, cognitive dysfunction, sleep abnormalities, autonomic manifestations, pain, and other symptoms that are made worse by exertion of any sort." The report further stated "Between 836,000 and 2.5 million Americans suffer from myalgic encephalomyelitis/chronic fatigue syndrome."
Millions Missing - A global campaign, first led by #MEAction in May 2016, which aims to gain awareness, community, education, research, funding and treatment equality for Myalgic Encephalomyelitis. The campaign uses the hashtag #MillionsMissing on Twitter.
mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.
National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).
National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.
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