Mark VanNess

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Dr J. Mark VanNess, PhD, is a member of the scientific advisory committee of the Workwell Foundation which specializes in two-day cardiopulmonary exercise testing (2-day CPET) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia and other fatiguing conditions. He has been working on ME/CFS since 1999, and is particularly interested in issues of autonomic dysfunction and mechanisms that produce post-exertional malaise.

Dr VanNess serves as an Associate Professor of Health, Exercise & Sport Sciences, Department of Sport Sciences, and an Adjunct Instructor at the College of Engineering, both at the University of the Pacific, Stockton, California.[1]

Education[edit | edit source]

  • 1990 - BS, Wheaton College, Illinois - Major: Exercise Physiology Minor: Biology[2]
  • 1993 - MS, California State University Sacramento - Thesis Title: "Lactate and Metabolic Responses to Controlled Frequency Breathing During Graded Tethered Swimming"[2]
  • 1997 - PhD, Florida State University - Dissertation Title: "Role of the Paraventricular Hypothalamic Nuclei and Neuropeptide Y in the Antihypertensive Effect of Food Restriction in Aortic Coarctation Hypertension"[2]
  • 1997-1999 - Post-Doctoral Training, Depts. of Pharmacology and Physiology, Univ. Texas Health Science Center. Gender differences in sodium-dependent hypertension[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Quality of Life/Functional Status (CPET)/Activity Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[3]

Notable studies[edit | edit source]

  • 2001, Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome[4]ABSTRACT
  • 2001, Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective[5]ABSTRACT
  • 2002, Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome[6]ABSTRACT
  • 2003, Subclassifying chronic fatigue syndrome through exercise testing[7]ABSTRACT
  • 2005, Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)[8]FULL TEXT
  • 2007, Legal and Scientific Considerations of the Exercise Stress Test[9]ABSTRACT
  • 2007, Diminished Cardiopulmonary Capacity During Post-Exertional Malaise[10]ABSTRACT
  • 2010, Post-exertional malaise in women with chronic fatigue syndrome[11]ABSTRACT
  • 2011, Diagnostic accuracy of symptoms characterising chronic fatigue syndrome[12]ABSTRACT
  • 2011, Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue[13]
  • 2013, Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome[14]FULL TEXT
  • 2018, Editorial - Checking our blind spots: current status of research evidence summaries in ME/CFS.[15](Introduction)
  • 2018, Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[16]Abstract
  • 2019, Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?[17](Full text)
  • 2019, Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing[18](Full text)

Clinic location[edit | edit source]

The Workwell Foundation is based in Ripon, California.

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]


References[edit | edit source]

  1. http://www.pacific.edu/Academics/Schools-and-Colleges/College-of-the-Pacific/Academics/Departments-and-Programs/Health-Exercise-and-Sport-Sciences/Our-Faculty/Mark-VanNess.html
  2. 2.02.12.22.3 J. Mark VanNess (July 2015), Curriculum Vitae (PDF) (curriculum vitae) 
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019. 
  4. VanNess, J Mark; Snell, Christopher R; Fredrickson, Dean M.; Strayer, David R.; Stevens, Staci R (2001), "Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 8 (3-4): 103-109, doi:10.1300/J092v08n03_09 
  5. Snell, Christopher R; Stevens, Staci R; VanNess, J Mark (2001), "Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective", Journal of Chronic Fatigue Syndrome, 8 (3-4): 117-121, doi:10.1300/J092v08n03_11 
  6. Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2002), "Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome", In Vivo, 16 (2): 107-9, PMID 12073768 
  7. VanNess, J Mark; Snell, Christopher R; Strayer, David R.; Dempsey, IV, Line; Stevens, Staci R (2003), "Subclassifying chronic fatigue syndrome through exercise testing", Med Sci Sports Exerc, 35 (6): 908-13, doi:10.1249/01.MSS.0000069510.58763.E8, PMID 12783037 
  8. Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2005), "Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)", In Vivo, 19 (2): 387-90, PMID 15796202 
  9. Ciccolella, Margaret; Stevens, Staci R.; Snell, Christopher R.; Vanness, J. Mark (2007), "Legal and Scientific Considerations of the Exercise Stress Test", Journal of Chronic Fatigue Syndrome, 14 (2): 61-75, doi:10.1300/J092v14n02_06 
  10. VanNess, J Mark; Snell, Christopher R; Stevens, Staci R (2007), "Diminished Cardiopulmonary Capacity During Post-Exertional Malaise", Journal of Chronic Fatigue Syndrome, 14 (2): 77-85, doi:10.1300/J092v14n02_07 
  11. VanNess, J Mark; Stevens, Staci R; Bateman, Lucinda; Stiles, Travis L; Snell, Christopher R (Jan 4, 2010), "Post-exertional malaise in women with chronic fatigue syndrome", J Womens Health (Larchmt), 2010 Feb;19 (2): 239-44, doi:10.1089/jwh.2009.1507, PMID 20095909 
  12. Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Diagnostic accuracy of symptoms characterizing chronic fatigue syndrome", Disabil Rehabil, 33 (19-20): 1768-75, doi:10.3109/09638288.2010.546936, PMID 21208154 
  13. Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue", Disabil Rehabil, 33 (25-26): 2596-604, doi:10.3109/09638288.2011.582925, PMID 21682669 
  14. Snell, Christopher R; Stevens, Staci R; Davenport, Todd E.; VanNess, J Mark (2013), "Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome", Physical Therapy, 93 (11): 1484–1492, doi:10.2522/ptj.20110368 
  15. Davenport, Todd E.; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (Jul 17, 2018). "Checking our blind spots: current status of research evidence summaries in ME/CFS". Br J Sports Med: bjsports–2018–099553. doi:10.1136/bjsports-2018-099553. ISSN 0306-3674. PMID 30018122. 
  16. Stevens, Staci; Snell, Chris; Stevens, Jared; Keller, Betsy; VanNess, J. Mark (2018). "Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Pediatrics. 6. doi:10.3389/fped.2018.00242. ISSN 2296-2360. 
  17. Davenport, Todd E.; Lehnen, Mary; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (Mar 22, 2019). "Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00082. ISSN 2296-2360. 
  18. Bouquet, Jerome; Li, Tony; Gardy, Jennifer L.; Kang, Xiaoying; Stevens, Staci; Stevens, Jared; VanNess, Mark; Snell, Christopher; Potts, James; Miller, Ruth R.; Morshed, Muhammad; McCabe, Mark; Parker, Shoshana; Uyaguari, Miguel; Tang, Patrick; Steiner, Theodore; Chan, Wee-Shian; De Souza, Astrid-Marie; Mattman, Andre; Patrick, David M.; Chiu, Charles Y. (Mar 21, 2019). "Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing". PLOS ONE. 14 (3): e0212193. doi:10.1371/journal.pone.0212193. ISSN 1932-6203. PMID 30897114. 
  19. http://www.meresearch.org.uk/news/meeting-at-stormont-parliament/

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

Accuracy - The "closeness of an observation to the true clinical state". With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.

Post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others.

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.