Mark VanNess

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Dr J. Mark VanNess, PhD, is a member of the scientific advisory committee of the Workwell Foundation which specializes in two-day cardiopulmonary exercise testing (2-day CPET) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia and other fatiguing conditions. He has been working on ME/CFS since 1999, and is particularly interested in issues of autonomic dysfunction and mechanisms that produce post-exertional malaise.

Dr VanNess serves as department chair and Full Professor of Health, Exercise & Sport Sciences, Department of Sport Sciences, and an Adjunct Instructor at the College of Engineering, both at the University of the Pacific, Stockton, California.[1]

Education[edit | edit source]

  • 1990 - BS, Wheaton College, Illinois - Major: Exercise Physiology Minor: Biology[2]
  • 1993 - MS, California State University Sacramento - Thesis Title: "Lactate and Metabolic Responses to Controlled Frequency Breathing During Graded Tethered Swimming"[2]
  • 1997 - PhD, Florida State University - Dissertation Title: "Role of the Paraventricular Hypothalamic Nuclei and Neuropeptide Y in the Antihypertensive Effect of Food Restriction in Aortic Coarctation Hypertension"[2]
  • 1997-1999 - Post-Doctoral Training, Depts. of Pharmacology and Physiology, Univ. Texas Health Science Center. Gender differences in sodium-dependent hypertension[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Quality of Life/Functional Status (CPET)/Activity Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[3]

Notable studies[edit | edit source]

  • 2020, Cardiopulmonary responses to exercise in an individual with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome during long-term treatment with intravenous saline: A case study[4] - (Full text)
  • 2020, Properties of measurements obtained during cardiopulmonary exercise testing in individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[5] - (Full text)
  • 2020, Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls[6] - (Full text)
  • 2019, Reproducibility of Measurements Obtained During Cardiopulmonary Exercise Testing in Individuals With Fatiguing Health Conditions: A Case Series[7] - (Abstract)
  • 2019, Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing[8] - (Full text)
  • 2019, Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?[9] - (Full text)
  • 2018, Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[10] - (Abstract)
  • 2018, Editorial - Checking our blind spots: current status of research evidence summaries in ME/CFS[11] - (Introduction)
  • 2013, Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome[12] - (Full text)
  • 2013, Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression[13] - (Full text)
  • 2011, Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue[14] - (Full text)
  • 2011, Diagnostic accuracy of symptoms characterising chronic fatigue syndrome[15] - (Abstract)
  • 2011, Psychomotor Function and Response Inhibition in Chronic Fatigue Syndrome[16] - (Full text)
  • 2010, Post-exertional malaise in women with chronic fatigue syndrome[17] - (Abstract)
  • 2007, Diminished Cardiopulmonary Capacity During Post-Exertional Malaise[18] - (Full text)
  • 2007, Legal and Scientific Considerations of the Exercise Stress Test[19] - (Abstract)
  • 2005, Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)[20] - (Full text)
  • 2003, Subclassifying chronic fatigue syndrome through exercise testing[21] - (Abstract)
  • 2002, Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome[22] - (Abstract)
  • 2001, Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective[23] - (Abstract)
  • 2001, Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome[24] - (Abstract)

Other publications[edit | edit source]

Clinic location[edit | edit source]

The Workwell Foundation is based in Ripon, California.

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ http://www.pacific.edu/Academics/Schools-and-Colleges/College-of-the-Pacific/Academics/Departments-and-Programs/Health-Exercise-and-Sport-Sciences/Our-Faculty/Mark-VanNess.html
  2. ↑ 2.0 2.1 2.2 2.3 J. Mark VanNess (July 2015), Curriculum Vitae (PDF) (curriculum vitae)
  3. ↑ "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
  4. ↑ Davenport, Todd E.; Ward, Michael K.; Stevens, Staci R.; Stevens, Jared; Snell, Christopher R.; VanNess, J. Mark (July 20, 2020). "Cardiopulmonary responses to exercise in an individual with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome during long-term treatment with intravenous saline: A case study". Work. 66 (2): 353–359. doi:10.3233/WOR-203214. PMID 32623426.
  5. ↑ Davenport, Todd E.; Stevens, Staci R.; Stevens, Jared; Snell, Christopher R.; Van Ness, J. Mark (July 20, 2020). "Properties of measurements obtained during cardiopulmonary exercise testing in individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Work. 66 (2): 247–256. doi:10.3233/WOR-203170. PMID 32568145.
  6. ↑ Mateo, Lariel J.; Chu, Lily; Stevens, Staci; Stevens, Jared; Snell, Christopher R.; Davenport, Todd; VanNess, J. Mark; Mark VanNess (July 20, 2020). "Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls". Work. 66 (2): 265–275. doi:10.3233/WOR-203168. PMID 32568143.
  7. ↑ Larson, Benjamin; Davenport, Todd E.; Stevens, Staci R.; Stevens, Jared; Van Ness, J. Mark; Snell, Christopher R. (October 2019). "Reproducibility of Measurements Obtained During Cardiopulmonary Exercise Testing in Individuals With Fatiguing Health Conditions: A Case Series". Cardiopulmonary Physical Therapy Journal. 30 (4): 145–152. doi:10.1097/CPT.0000000000000100. ISSN 1541-7891.
  8. ↑ Bouquet, Jerome; Li, Tony; Gardy, Jennifer L.; Kang, Xiaoying; Stevens, Staci; Stevens, Jared; VanNess, Mark; Snell, Christopher; Potts, James; Miller, Ruth R.; Morshed, Muhammad; McCabe, Mark; Parker, Shoshana; Uyaguari, Miguel; Tang, Patrick; Steiner, Theodore; Chan, Wee-Shian; De Souza, Astrid-Marie; Mattman, Andre; Patrick, David M.; Chiu, Charles Y. (March 21, 2019). "Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing". PLOS ONE. 14 (3): e0212193. doi:10.1371/journal.pone.0212193. ISSN 1932-6203. PMID 30897114.
  9. ↑ Davenport, Todd E.; Lehnen, Mary; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (March 22, 2019). "Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00082. ISSN 2296-2360.
  10. ↑ Stevens, Staci; Snell, Chris; Stevens, Jared; Keller, Betsy; VanNess, J. Mark (2018). "Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Pediatrics. 6. doi:10.3389/fped.2018.00242. ISSN 2296-2360.
  11. ↑ Davenport, Todd E.; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (July 17, 2018). "Checking our blind spots: current status of research evidence summaries in ME/CFS". Br J Sports Med: bjsports–2018–099553. doi:10.1136/bjsports-2018-099553. ISSN 0306-3674. PMID 30018122.
  12. ↑ Snell, Christopher R; Stevens, Staci R; Davenport, Todd E.; VanNess, J Mark (2013). "Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome". Physical Therapy. 93 (11): 1484–1492. doi:10.2522/ptj.20110368.
  13. ↑ Meyer, Jacob D.; Light, Alan R.; Shukla, Sanjay K.; Clevidence, Derek; Yale, Steven; Stegner, Aaron J.; Cook, Dane B. (October 2013). "Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression". Fatigue: Biomedicine, Health & Behavior. 1 (4): 190–209. doi:10.1080/21641846.2013.838444. ISSN 2164-1846.
  14. ↑ Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue", Disabil Rehabil, 33 (25–26): 2596–2604, doi:10.3109/09638288.2011.582925, PMID 21682669
  15. ↑ Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Diagnostic accuracy of symptoms characterizing chronic fatigue syndrome", Disabil Rehabil, 33 (19–20): 1768–75, doi:10.3109/09638288.2010.546936, PMID 21208154
  16. ↑ https://www.sciencedirect.com/science/article/abs/pii/S0165178110004543
  17. ↑ VanNess, J Mark; Stevens, Staci R; Bateman, Lucinda; Stiles, Travis L; Snell, Christopher R (January 4, 2010). "Post-exertional malaise in women with chronic fatigue syndrome". J Womens Health (Larchmt). 19 (2): 239–244. doi:10.1089/jwh.2009.1507. PMID 20095909.
  18. ↑ VanNess, J Mark; Snell, Christopher R; Stevens, Staci R (2007). "Diminished Cardiopulmonary Capacity During Post-Exertional Malaise". Journal of Chronic Fatigue Syndrome. 14 (2): 77–85. doi:10.1300/J092v14n02_07.
  19. ↑ Ciccolella, Margaret; Stevens, Staci R.; Snell, Christopher R.; Vanness, J. Mark (2007), "Legal and Scientific Considerations of the Exercise Stress Test", Journal of Chronic Fatigue Syndrome, 14 (2): 61–75, doi:10.1300/J092v14n02_06
  20. ↑ Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2005), "Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)", In Vivo, 19 (2): 387–90, PMID 15796202
  21. ↑ VanNess, J Mark; Snell, Christopher R; Strayer, David R.; Dempsey, IV, Line; Stevens, Staci R (2003), "Subclassifying chronic fatigue syndrome through exercise testing", Med Sci Sports Exerc, 35 (6): 908–913, doi:10.1249/01.MSS.0000069510.58763.E8, PMID 12783037
  22. ↑ Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2002), "Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome", In Vivo, 16 (2): 107–9, PMID 12073768
  23. ↑ Snell, Christopher R; Stevens, Staci R; VanNess, J Mark (2001), "Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective", Journal of Chronic Fatigue Syndrome, 8 (3–4): 117–121, doi:10.1300/J092v08n03_11
  24. ↑ VanNess, J Mark; Snell, Christopher R; Fredrickson, Dean M.; Strayer, David R.; Stevens, Staci R (2001). "Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome. 8 (3–4): 103–109. doi:10.1300/J092v08n03_09.
  25. ↑ Snell, C. R., Van Ness, J. M., & Stevens, S. R. (2004). When Working Out Doesn’t Work Out. CFIDS Chronicle, 17(3), 6–9. https://scholarlycommons.pacific.edu/cop-facarticles/456
  26. ↑ Van Ness, J. M. (2014). An Exercise in Objectivity: A realistic approach to exercise in ME/CFS. Paper presented at Watershed Conference in Bristol, England
  27. ↑ "Meeting at Stormont Parliament". ME Research UK. February 12, 2014.

two-day cardiopulmonary exercise test (CPET) - A diagnostic test which involves testing an ME/CFS patient exercising on an exercise machine, while monitoring their respiration, especially oxygen consumption. This test is repeated the following day in order to confirm the patient's inability to replicate the first-day performance. This test is thought to be the most objective way to detect post-exertional malaise.

See two-day cardiopulmonary exercise test.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The human virome is the collection of all viruses that are found in or on humans.[1]

virome The human virome is the collection of all viruses that are found in or on humans.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

The "closeness of an observation to the true clinical state".[2] With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.[3]

accuracy The "closeness of an observation to the true clinical state". With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

See National Institutes of Health.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) - Chronic Fatigue and Immune Dysfunction Syndrome is another term for Chronic Fatigue Syndrome, but one which emphasizes the immunological aspects of the disease. Popular in the 1990s, this term has apparently fallen into disuse.

See Chronic Fatigue and Immune Dysfunction Syndrome.

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