List of abnormal findings in chronic fatigue syndrome and myalgic encephalomyelitis

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Myalgic encephalomyelitis/chronic fatigue syndrome is a complex multi-system disease and biological abnormalities in patients have been found affecting multiple bodily systems. No single biomarker-based diagnostic test has been validated but patients have a range abnormal physical findings affecting multiple bodily systems.[1] The CDC states that diagnosing ME/CFS relies on a physical and psychiatric assessment, observations, medical history, clinical interview, and results from a mix of blood and urine tests.[2]

Nervous system[edit | edit source]

Brain[edit | edit source]

  • Progressive brain changes[3]

Central nervous system[edit | edit source]

Autonomic nervous system[edit | edit source]

Peripheral nervous system[edit | edit source]

Muscular system[edit | edit source]

Immune system[edit | edit source]

Immune dysregulation[edit | edit source]

Chronic infection[edit | edit source]

Lymphatic system[edit | edit source]

Cardiovascular system[edit | edit source]

Heart[edit | edit source]

Circulation[edit | edit source]

Blood vessels[edit | edit source]

Blood[edit | edit source]

Digestive system[edit | edit source]

Gastrointestinal tract[edit | edit source]

Liver[edit | edit source]

Nutrition[edit | edit source]

Metabolism[edit | edit source]

  • Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review[72]
  • Analysis of peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction, supporting a model of deficient ATP production in ME/CFS.[73]

Cellular respiration[edit | edit source]

Exercise[edit | edit source]

  • reduced pain threshold[81]
  • translocation of bacteria[82]
  • loss of capacity to recover from acidosis on repeat exercise[83]
  • increased expression of sensory, adrenergic and immune genes following muscle exertion[84][85][86]
  • decreased oxygen utilization[87]
Abnormal findings in Chronic fatigue syndrome and myalgic encephalomyelitis. There is no single biomarker, but tests have found differences in blood flow to the brain, hand grip strength, metabolite and mitochondria abnormalities, reduced heart output, white and red blood cell differences, reduced blood volume, differences in gut bacteria, neuroinflammation, abnormal responses to exercise, and other abnormalities.

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

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  2. Centers of Disease Control (May 15, 2019). "Diagnosis of ME/CFS | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Centers for Disease Control and Prevention. Retrieved September 26, 2020.
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Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

orthostatic intolerance (OI) - The development of symptoms when standing upright, where symptoms are relieved upon reclining. Patients with orthostatic intolerance have trouble remaining upright for more than a few seconds or a few minutes, depending upon severity. In severe orthostatic intolerance, patients may not be able to sit upright in bed. Orthostatic intolerance is often a sign of dysautonomia. There are different types of orthostatic intolerance, including postural orthostatic tachycardia syndrome (POTS).

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

anticholinergic (ACh) - Involving blocking the neurotransmitter acetylcholine. Anticholinergic side effects may include dilated pupils in the eyes, photophobia, dry mouth, decreased mucus in the lungs, respiratory depression, decreased gastrointestinal motility, constipation, decreased then increased blood pressure, rapid heartbeat or heart palpitations, urinary retention, vasodilation, drowsiness, confusion, and agitation, and decreased sweating.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

membrane The word "membrane" can have different meanings in different fields of biology. In cell biology, a membrane is a layer of molecules that surround its contents. Examples of cell-biology membranes include the "cell membrane" that surrounds a cell, the "mitochondrial membranes" that form the outer layers of mitochondria, and the "viral envelope" that surrounds enveloped viruses. In anatomy or tissue biology, a membrane is a barrier formed by a layer of cells. Examples of anatomical membranes include the pleural membranes that surrounds the lungs, the pericardium which surrounds the heart, and some of the layers within the blood-brain barrier.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

metabolomics The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

The information provided at this site is not intended to diagnose or treat any illness.
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