List of abnormal findings in chronic fatigue syndrome and myalgic encephalomyelitis

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Myalgic encephalomyelitis is a multi-system disease. Numerous biological abnormalities have been found in multiple bodily system, however no common, central cause or mechanism has yet been elucidated.

Nervous system[edit | edit source]

Central nervous system[edit | edit source]

Autonomic nervous system[edit | edit source]

Peripheral nervous system[edit | edit source]

Muscular system[edit | edit source]

Immune system[edit | edit source]

Immune dysregulation[edit | edit source]

Chronic infection[edit | edit source]

Lymphatic system[edit | edit source]

Cardiovascular system[edit | edit source]

Heart[edit | edit source]

Circulation[edit | edit source]

Blood vessels[edit | edit source]

Blood[edit | edit source]

Digestive system[edit | edit source]

Gastrointestinal tract[edit | edit source]

Liver[edit | edit source]

Nutrition[edit | edit source]

Metabolism[edit | edit source]

Cellular respiration[edit | edit source]

Exercise[edit | edit source]

  • reduced pain threshold[75]
  • translocation of bacteria[76]
  • loss of capacity to recover from acidosis on repeat exercise[77]
  • increased expression of sensory, adrenergic and immune genes following muscle exertion[78][79][80]
  • decreased oxygen utilization[81]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Mathew, Sanjay J.; Mao, Xiangling; Keegan, Kathryn A.; Levine, Susan M.; Smith, Eric L. P.; Heier, Linda A.; Otcheretko, Viktor; Coplan, Jeremy D.; Shungu, Dikoma C. (Apr 2009). "Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: anin vivo3.0 T1H MRS imaging study". NMR in Biomedicine. 22 (3): 251–258. doi:10.1002/nbm.1315. ISSN 0952-3480. 
  2. Murrough, James W.; Mao, Xiangling; Collins, Katherine A.; Kelly, Chris; Andrade, Gizely; Nestadt, Paul; Levine, Susan M.; Mathew, Sanjay J.; Shungu, Dikoma C. (Jul 2010). "Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder". NMR in Biomedicine. 23 (6): 643–650. doi:10.1002/nbm.1512. ISSN 1099-1492. PMID 20661876. 
  3. Shungu, Dikoma C.; Weiduschat, Nora; Murrough, James W.; Mao, Xiangling; Pillemer, Sarah; Dyke, Jonathan P.; Medow, Marvin S.; Natelson, Benjamin H.; Stewart, Julian M. (Sep 2012). "Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology". NMR in biomedicine. 25 (9): 1073–1087. doi:10.1002/nbm.2772. ISSN 1099-1492. PMC 3896084Freely accessible. PMID 22281935. 
  4. Natelson, Benjamin H.; Vu, Diana; Coplan, Jeremy D.; Mao, Xiangling; Blate, Michelle; Kang, Guoxin; Soto, Eli; Kapusuz, Tolga; Shungu, Dikoma C. (Jan 2, 2017). "Elevations of ventricular lactate levels occur in both chronic fatigue syndrome and fibromyalgia". Fatigue: Biomedicine, Health & Behavior. 5 (1): 15–20. doi:10.1080/21641846.2017.1280114. ISSN 2164-1846. PMC 5754037Freely accessible. PMID 29308330. 
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serum - the clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation

serum - the clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation

Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.