Pyruvate dehydrogenase

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Pyruvate dehydrogenase (PDH) is an enzyme that is part of the citric acid cycle. It catalyzes the reaction that transforms pyruvate into acetyl-CoA, a process called pyruvate decarboxylation. PDH activity is inhibited by pyruvate dehydrogenase kinase (PDK).

PDH activity is controlled by multiple different factors, including but not limited to:

  • PDH kinases (PDKs), that inhibit activity of PDH enzymes
  • PDH phosphatases that yank away PDH’s phosphate group so it does not function properly
  • Sirtuin 4 (SIRT4), which is also an inhibitor for PDH
  • PDK1, 2, 3, and 4
  • A shift in these or their expression means a shift towards higher glucose, lower pyruvate, lower Acetyl Co-A, and fewer energy-rich molecules produced in the cell to do work.

PDH activity can be increased by supplementing with L-carnitine.[1]

In ME/CFS[edit | edit source]

A large study by Fluge and Mella of 200 patients meeting the Canadian Consensus Criteria and 102 controls found a pattern of amino acids that suggested functional impairment of pyruvate dehydrogenase (PDH), supported by increased mRNA expression of the inhibitory PDH kinases 1, 2, and 4; sirtuin 4; and PPARδ in peripheral blood mononuclear cells from both sexes.[2]

Learn more[edit | edit source]

References[edit | edit source]

  1. Arenas, J.; Huertas, R.; Campos, Y.; Díaz, A. E.; Villalón, J. M.; Vilas, E. (Mar 14, 1994). "Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes". FEBS letters. 341 (1): 91–93. doi:10.1016/0014-5793(94)80246-7. ISSN 0014-5793. PMID 8137928. 
  2. Tronstad, Karl J.; Dahl, Olav; Ueland, Per M.; Helgeland, Lars; Sommerfelt, Kristian; McCann, Adrian; Schäfer, Christoph; Bohnen, Louis M. L. J.; Baranowska, Katarzyna A. (Jan 3, 2017). "Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome". JCI Insight. 1 (21). doi:10.1172/jci.insight.89376. ISSN 0021-9738. 

enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.