Creatine kinase

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Creatine kinase (CK) is an enzyme that uses ATP to convert creatine into phosphocreatine and adenosine diphosphate. It is an enzyme found in the inner mitochondrial membrane. Creatine kinase is a marker of tissue damage. There are three isoenzymes of creatine kinase: skeletal muscle CK-MM, myocardium CK-MB, & brain and smooth muscle CK-BB. Elevated levels are found in patients suffering from heart attack, severe muscle breakdown, and muscular dystrophy.

A study found increased levels of creatine kinase in the muscle biopses of patients with postviral fatigue syndrome.[1] A study measured plasma creatine kinase as a surrogate measure of a lowered oxidative phosphorylation in skeletal muscle of ME/CFS patients (n=15) and healthy controls. They found low plasma creatine kinase levels before and 24 hours after an exercise challenge in ME/CFS patients and healthy controls. This suggested muscle mitochondria were normal, since 24 hours after strenuous exercise CK did not leak to the blood, as is the case in patients with defective oxidative phosphorylation.[2] A 2019 study found markedly reduced serum CK concentrations in severe ME/CFS (n=56), but not in less severe cases.[3]

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enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

serum - the clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.