In ME and CFS[edit | edit source]
Several of the key symptoms observed by Melvin Ramsay and a part of his Ramsay definition involved muscle including muscle fatigability along with muscle pain and clumsiness (ataxia). Patients also complain of muscle fasciculations.
- mitochondrial abnormalities found via muscle biopsy including: mitochondrial degeneration, deletions of mitochondrial DNA , the reduction of mitochondrial activity
- Increased urinary creatine excretion during relapses
- Increased creatine kinase (postviral fatigue syndrome)
- Persistence of enteroviruses in muscle tissue
Studies[edit | edit source]
See also[edit | edit source]
- Muscle biopsy
- Muscle fasciculations
- Muscle fatigability
- Skeletal muscle
Learn more[edit | edit source]
References[edit | edit source]
- Behan, W. M. H.; More, I. A. R.; Behan, P. O. (Dec 1991). "Mitochondrial abnormalities in the postviral fatigue syndrome". Acta Neuropathologica. 83 (1): 61–65. doi:10.1007/bf00294431. ISSN 0001-6322.
- "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208 (2): 117–120. Apr 19, 1996. doi:10.1016/0304-3940(96)12559-3. ISSN 0304-3940.
- Zhang, C.; Baumer, A.; Mackay, I. R.; Linnane, A. W.; Nagley, P. (Apr 1995). "Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome". Human Molecular Genetics. 4 (4): 751–754. ISSN 0964-6906. PMID 7633428.
- Albrecht, Robert (Mar 21, 1964). "Epidemic Neuromyasthenia Outbreak in a Convent in New York State". Journal of the American Medical Association. 187: 904–907.
- Gow, J. W.; Behan, W. M. H.; Simpson, K.; McGarry, F.; Keir, S.; Behan, P. O. (Jan 1, 1994). "Studies on Enterovirus in Patients with Chronic Fatigue Syndrome". Clinical Infectious Diseases. 18 (Supplement_1): S126–S129. doi:10.1093/clinids/18.Supplement_1.S126. ISSN 1537-6591.
- Cunningham, Louise; Bowles, N. E.; Lane, R. J. M.; Dubowitz, V.; Archard, L. C. (1990). "Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA". Journal of General Virology. 71 (6): 1399–1402. doi:10.1099/0022-1317-71-6-1399.
- Archard, L C; Bowles, N E; Behan, P O; Bell, E J; Doyle, D (Jun 1, 1988). "Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase, Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase". Journal of the Royal Society of Medicine. 81 (6): 326–329. doi:10.1177/014107688808100608. ISSN 0141-0768. PMID 3404526.
- Gow, J. W.; Behan, W. M.; Clements, G. B.; Woodall, C.; Riding, M.; Behan, P. O. (Mar 23, 1991). "Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome". BMJ. 302 (6778): 692–696. doi:10.1136/bmj.302.6778.692. ISSN 0959-8138. PMID 1850635.
- Pietrangelo, Tiziana; Fulle, Stefania; Coscia, Francesco; Gigliotti, Paola Virginia; Fanò-Illic, Giorgio (Sep 7, 2018). "Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome". European Journal of Translational Myology. 28 (3). doi:10.4081/ejtm.2018.7688. ISSN 2037-7460. PMID 30344981.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.