Muscle

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In ME and CFS[edit | edit source]

Several of the key symptoms observed by Melvin Ramsay and a part of his Ramsay definition involved muscle including muscle fatigability along with muscle pain and clumsiness (ataxia). Patients also complain of muscle fasciculations.

Numerous abnormalities have been found in the skeletal muscle of Myalgic Encephalomyelitis patients including:

Studies[edit | edit source]

  • 2018, Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome[9](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Behan, W. M. H.; More, I. A. R.; Behan, P. O. (Dec 1991). "Mitochondrial abnormalities in the postviral fatigue syndrome". Acta Neuropathologica. 83 (1): 61–65. doi:10.1007/bf00294431. ISSN 0001-6322. 
  2. 2.02.1 "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208 (2): 117–120. Apr 19, 1996. doi:10.1016/0304-3940(96)12559-3. ISSN 0304-3940. 
  3. Zhang, C.; Baumer, A.; Mackay, I. R.; Linnane, A. W.; Nagley, P. (Apr 1995). "Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome". Human Molecular Genetics. 4 (4): 751–754. ISSN 0964-6906. PMID 7633428. 
  4. Albrecht, Robert (Mar 21, 1964). "Epidemic Neuromyasthenia Outbreak in a Convent in New York State". Journal of the American Medical Association. 187: 904–907. 
  5. Gow, J. W.; Behan, W. M. H.; Simpson, K.; McGarry, F.; Keir, S.; Behan, P. O. (Jan 1, 1994). "Studies on Enterovirus in Patients with Chronic Fatigue Syndrome". Clinical Infectious Diseases. 18 (Supplement_1): S126–S129. doi:10.1093/clinids/18.Supplement_1.S126. ISSN 1537-6591. 
  6. Cunningham, Louise; Bowles, N. E.; Lane, R. J. M.; Dubowitz, V.; Archard, L. C. (1990). "Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA". Journal of General Virology. 71 (6): 1399–1402. doi:10.1099/0022-1317-71-6-1399. 
  7. Archard, L C; Bowles, N E; Behan, P O; Bell, E J; Doyle, D (Jun 1, 1988). "Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase, Postviral Fatigue Syndrome: Persistence of Enterovirus RNA in Muscle and Elevated Creatine Kinase". Journal of the Royal Society of Medicine. 81 (6): 326–329. doi:10.1177/014107688808100608. ISSN 0141-0768. PMID 3404526. 
  8. Gow, J. W.; Behan, W. M.; Clements, G. B.; Woodall, C.; Riding, M.; Behan, P. O. (Mar 23, 1991). "Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome". BMJ. 302 (6778): 692–696. doi:10.1136/bmj.302.6778.692. ISSN 0959-8138. PMID 1850635. 
  9. Pietrangelo, Tiziana; Fulle, Stefania; Coscia, Francesco; Gigliotti, Paola Virginia; Fanò-Illic, Giorgio (Sep 7, 2018). "Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome". European Journal of Translational Myology. 28 (3). doi:10.4081/ejtm.2018.7688. ISSN 2037-7460. PMID 30344981. 

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

BMJ - The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.