John McLaren-Howard

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

John McLaren-Howard, DSc,[1] is the director of the Acumen Medical Limited, a laboratory in Devon, UK.[2] He is a Fellow of the American College of Nutrition.[1]

He was a co-author of the publication "Myalgic Encephalomyelitis – Adult & Paediatric: International Consensus Primer for Medical Practitioners," following the 2012 publication of the 2012 International Consensus Criteria (and co-written with many of the same authors of the latter).[1]

Notable studies[edit | edit source]

  • 2009, Chronic fatigue syndrome and mitochondrial dysfunction[3]
  • 2012, Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[4]
  • 2013, Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit[5]

References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
  2. ↑ "Acumen Medical Limited". cqc.org.uk. Retrieved January 21, 2019.
  3. ↑ Myhill, S; Booth, NE; McLaren-Howard, J (January 15, 2009), "Chronic fatigue syndrome and mitochondrial dysfunction", International Journal of Clinical Experimental Medicine, 2 (1): 1–16, PMID 19436827
  4. ↑ Booth, NE; Myhill, S; McLaren-Howard, J (June 15, 2012), "Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", International Journal of Clinical Experimental Medicine, 5 (3): 208–220, PMID 22837795
  5. ↑ Myhill, S; Booth, NE; McLaren-Howard, J (2013), "Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit", International Journal of Clinical Experimental Medicine, 6 (1): 1–15, PMID 23236553

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

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