Lactic acid is a biologically important acid and a by-product of anaerobic metabolism. The conjugate base of lactic acid is called lactate. Most of the time, the term "lactic acid" refers to L-lactic acid, the form of lactic acid produced in animals. Some bacteria produce a different form, called D-lactic acid. There is evidence that lactic acid in animals may be an important fuel for myocardial energy metabolism.
In human disease[edit | edit source]
ME/CFS[edit | edit source]
Elevated blood lactate has been found in both resting ME/CFS patients and following exertion. ME/CFS patients with higher elevated lactate at rest may have more severe post-exertional malaise after activity.
See also[edit | edit source]
Learn more[edit | edit source]
The talk page may contain suggestions.
References[edit | edit source]
- Chatham, John C (July 15, 2002). "Lactate – the forgotten fuel!". The Journal of Physiology. 542 (Pt 2): 333. doi:10.1113/jphysiol.2002.020974. ISSN 0022-3751. PMC 2290415. PMID 12122132.
- Ghali, Alaa; Lacout, Carole; Ghali, Maria; Gury, Aline; Beucher, Anne-Berengere; Lozac’h, Pierre; Lavigne, Christian; Urbanski, Geoffrey (December 11, 2019). "Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome". Scientific Reports. 9 (1): 1–9. doi:10.1038/s41598-019-55473-4. ISSN 2045-2322.
post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.