Lactic acid

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Lactic acid is a biologically important acid and a by-product of anaerobic metabolism. The conjugate base of lactic acid is called lactate. Most of the time, the term "lactic acid" refers to L-lactic acid, the form of lactic acid produced in animals. Some bacteria produce a different form, called D-lactic acid. There is evidence that lactic acid in animals may be an important fuel for myocardial energy metabolism.[1]

In human disease[edit | edit source]

ME/CFS[edit | edit source]

Elevated ventricular lactate has been found in the brains of ME/CFS patients.[2] Elevated blood lactate has been found in both resting ME/CFS patients[3] and following exertion. ME/CFS patients with higher elevated lactate at rest may have more severe post-exertional malaise after activity.[3]

See also[edit | edit source]

Learn more[edit | edit source]

https://www.khanacademy.org/test-prep/mcat/physical-sciences-practice/physical-sciences-practice-tut/e/enzymes---passage-2

References[edit | edit source]

  1. ↑ Chatham, John C (July 15, 2002). "Lactate – the forgotten fuel!". The Journal of Physiology. 542 (Pt 2): 333. doi:10.1113/jphysiol.2002.020974. ISSN 0022-3751. PMC 2290415. PMID 12122132.
  2. ↑ Natelson, Benjamin; Mao, Xiangling; Stegner, Aaron J; Lange, Gudrun; Vu, Diana; Blate, Michelle; Kang, Guoxin; Soto, Eli; Kapusuz, Tolga; Shungu, Dikoma C (2017). "Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity". Journal of the Neurological Sciences. 375: 411-416. doi:10.1016/j.jns.2017.02.046. PMC 5393352.
  3. ↑ 3.0 3.1 Ghali, Alaa; Lacout, Carole; Ghali, Maria; Gury, Aline; Beucher, Anne-Berengere; Lozac’h, Pierre; Lavigne, Christian; Urbanski, Geoffrey (December 11, 2019). "Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with Myalgic encephalomyelitis/Chronic fatigue syndrome". Scientific Reports. 9 (1): 1–9. doi:10.1038/s41598-019-55473-4. ISSN 2045-2322.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

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