Portal:Energy metabolism

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Energy metabolism

Abnormalities in energy metabolism and exercise intolerance are key features of myalgic encephalomyelitis, whose cardinal symptom is post-exertional malaise. (more...)


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Two-day cardiopulmonary exercise testing or 2-day CPET is a of post-exertional malaise (PEM), one of the cardinal symptoms that distinguishes between individuals with and without ME/CFS. The hypothesis is that ME/CFS patients are almost unique in having a severe deterioration in the second of the two cardiopulmonary exercise tests performed on consecutive days. The test is also frequently used in research to compare outcomes pre- and post- exercise. (more...)


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Dr J. Mark VanNess, PhD, is a member of the scientific advisory committee of the Workwell Foundation which specializes in two-day cardiopulmonary exercise testing (2-day CPET) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia and other fatiguing conditions. He has been working on ME/CFS since 1999, and is particularly interested in issues of autonomic dysfunction and mechanisms that produce post-exertional malaise.

Dr VanNess serves as an Associate Professor of Health, Exercise & Sport Sciences, Department of Sport Sciences, and an Adjunct Instructor at the College of Engineering, both at the University of the Pacific, Stockton, California. (more...)


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2010 VanNess Post exertional worsening of symptoms chart.png
Post-exertional malaise symptoms after exercise in ME/CFS.


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.