Kynurenine

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Kynurenine is an amino acid that is produced in the body by the metabolism of the essential amino acid tryptophan.[1][2]

ME/CFS[edit | edit source]

The Open Medicine Foundation's ME/CFS Severely Ill Big Data Study found that patients in the study group with severe ME had one of several defects involving the IDO2 gene, which affected tryptophan - kynurenine metabolism.[3] This lead to the Metabolic Trap theory.[3]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Medical Definition of KYNURENINE". www.merriam-webster.com. Retrieved Nov 30, 2019. 
  2. National Center for Biotechnology Information. "Kynurenine". PubChem Database. Retrieved Jan 19, 2020. 
  3. 3.03.1 Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.