The kynurenine pathway or tryptophan kynurenine pathway is the primary route for metabolizing the essential amino acid tryptophan in humans and other mammals in order to generate cellular energy in the form of nicotinamide adenine dinucleotide (NAD+).
Function[edit | edit source]
The kynurenine pathway
ME/CFS[edit | edit source]
The metabolic trap hypothesis suggests that a metabolic problem exists in one or more areas of a person with ME/CFS, with a defect in the IDO2 enzyme of the tryptophan kynurenine pathway being identified as a possible metabolic trap.
See also[edit | edit source]
Learn more[edit | edit source]
- What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?
- Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?
References[edit | edit source]
- Chen, Yiquan; Guillemin, Gilles J. (Jan 8, 2009). "Kynurenine Pathway Metabolites in Humans: Disease and Healthy States". International Journal of Tryptophan Research : IJTR. 2: 1–19. ISSN 1178-6469. PMC . PMID 22084578.
- Savitz, Jonathan (Apr 12, 2019). "The kynurenine pathway: a finger in every pie". Molecular Psychiatry: 1–17. doi:10.1038/s41380-019-0414-4. ISSN 1476-5578.
- Davis, I.; Liu, A. (Jul 2015). "What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?". Expert review of neurotherapeutics. 15 (7): 719–721. doi:10.1586/14737175.2015.1049999. ISSN 1473-7175. PMID 26004930.
- Mellor, Andrew L.; Lemos, Henrique; Huang, Lei (2017). "Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?". Frontiers in Immunology. 8. doi:10.3389/fimmu.2017.01360. ISSN 1664-3224.
enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.
metabolic trap hypothesis - An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.