Indoleamine-2,3-dioxygenase 2

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Indoleamine-2,3-dioxygenase 2 is more commonly known as IDO2 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan.[1] The gene encoding IDO2, also known as IDOL1, is also sometimes referred to as IDO2.[2]

Function[edit | edit source]

ME/CFS[edit | edit source]

The ME/CFS Severely Ill Big Data Project analyzed genes of 20 patients who were severely ill with ME and CFS, and identified several different genetic defects in the genes encoding the IDO2 enzyme.

Notable studies and publications[edit | edit source]

  • 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[3](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

  • IDO2 - National Center for Biotechnology Information

References[edit | edit source]

  1. Ball, Helen J.; Yuasa, Hajime J.; Austin, Christopher J. D.; Weiser, Silvia; Hunt, Nicholas H. (March 1, 2009). "Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway". The International Journal of Biochemistry & Cell Biology. 41 (3): 467–471. doi:10.1016/j.biocel.2008.01.005. ISSN 1357-2725.
  2. National Center for Biotechnology Information (March 13, 2020). "IDO2 indoleamine 2,3-dioxygenase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved May 1, 2020.
  3. Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

metabolic trap hypothesis An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.

etiology The cause of origin, especially of a disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.