Indoleamine-2,3-dioxygenase 2

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Indoleamine-2,3-dioxygenase 2 is more commonly known as IDO2 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan.[1] The gene encoding IDO2, also known as IDOL1, is also sometimes referred to as IDO2.[2]

Function[edit | edit source]

ME/CFS[edit | edit source]

The ME/CFS Severely Ill Big Data Project analyzed genes of 20 patients who were severely ill with ME and CFS, and identified several different genetic defects in the genes encoding the IDO2 enzyme.

Notable studies and publications[edit | edit source]

  • 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[3](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

  • IDO2 - National Center for Biotechnology Information

References[edit | edit source]

  1. Ball, Helen J.; Yuasa, Hajime J.; Austin, Christopher J. D.; Weiser, Silvia; Hunt, Nicholas H. (Mar 1, 2009). "Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway". The International Journal of Biochemistry & Cell Biology. 41 (3): 467–471. doi:10.1016/j.biocel.2008.01.005. ISSN 1357-2725. 
  2. National Center for Biotechnology Information (Mar 13, 2020). "IDO2 indoleamine 2,3-dioxygenase 2 [Homo sapiens (human)] - Gene - NCBI". Retrieved May 1, 2020. 
  3. Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue (idiopathic chronic fatigue) without additional symptoms. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

metabolic trap hypothesis - An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.

etiology - The cause of origin, especially of a disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.