Indoleamine-2,3-dioxygenase 1

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Indoleamine-2,3-dioxygenase 1 or IDO or IDO-1 is more commonly known as IDO1 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan to N-formyl kynurenine.[1][2] The gene encoding IDO1 is also sometimes referred to as IDO1.[1]

Function[edit | edit source]

ME/CFS[edit | edit source]

Notable studies and publications[edit | edit source]

  • 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[3] (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

  • IDO1 - National Center for Biotechnology Information

References[edit | edit source]

  1. 1.0 1.1 National Center for Biotechnology Information (March 22, 2020). "IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI". Retrieved May 1, 2020.
  2. Ball, Helen J.; Yuasa, Hajime J.; Austin, Christopher J.D.; Weiser, Silvia; Hunt, Nicholas H. (March 1, 2009). "Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway". The International Journal of Biochemistry & Cell Biology. 41 (3): 467–471. doi:10.1016/j.biocel.2008.01.005. ISSN 1357-2725.
  3. Phair, RobertD.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.