Indoleamine-2,3-dioxygenase 1

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Indoleamine-2,3-dioxygenase 1 or IDO or IDO-1 is more commonly known as IDO1 is an enzyme in the kynurenine pathway involved in the metabolism of the essential amino acid tryptophan to N-formyl kynurenine.[1][2] The gene encoding IDO1 is also sometimes referred to as IDO1.[1]

Function[edit | edit source]

ME/CFS[edit | edit source]

Notable studies and publications[edit | edit source]

  • 2019, The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS[3](Full text)

See also[edit | edit source]

Learn more[edit | edit source]

  • IDO1 - National Center for Biotechnology Information

References[edit | edit source]

  1. 1.01.1 National Center for Biotechnology Information (March 22, 2020). "IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved May 1, 2020.
  2. Ball, Helen J.; Yuasa, Hajime J.; Austin, Christopher J. D.; Weiser, Silvia; Hunt, Nicholas H. (March 1, 2009). "Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway". The International Journal of Biochemistry & Cell Biology. 41 (3): 467–471. doi:10.1016/j.biocel.2008.01.005. ISSN 1357-2725.
  3. Phair, Robert D.; Davis, Ronald W.; Kashi, Alex A. (2019). "The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS". Diagnostics. 9 (3): 82. doi:10.3390/diagnostics9030082.

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

metabolic trap hypothesis An hypothesis which proposes that the normal metabolic functioning of the cell has become "trapped" in an abnormal state, which may lead to body-wide symptoms.

etiology The cause of origin, especially of a disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.