These are selected articles related to the energy metabolism which appear on Portal:Energy metabolism.
A single cellular mitochondrion
are organelles found in all cells that have a nucleus. In the human body, that would be all cells except red blood cells. They generate most of a cell's energy by manufacturing adenosine triphosphate, ATP
. Mitochondria have their own independent genome
called mitochondrial DNA
) is a worsening of many ME/CFS
symptoms as a result of physical or mental exertion. Patients, ME/CFS
organizatons, clinicians and researchers that work in the ME/CFS field often referred to it as "the marker," i.e., the main symptom that differentiates ME
from other fatiguing illnesses. PEM can last for days to weeks after the exertion. (more...
Citric acid cycle/Krebs cycle/TCA cycle
is a series of enzyme
-catalyzed chemical reactions that form a key part of aerobic respiration in cells. This work takes place inside the mitochondria
Energy Envelope Theory
is a self-management tool to reduce symptom severity and the frequency of relapses. This theory suggests that because variations in day-to-day energy levels are often unpredictable in people with ME/CFS
, they are to assess their perceived energy levels on a daily basis (or in smaller time increments, as needed) and use that level to gauge their energy expenditure for the day. It encourages people with ME/CFS
to accept their daily energy limitations and not exceed or fight them. (more...
(PDH) is an enzyme
that is part of the citric acid cycle
. It catalyzes the reaction that transforms pyruvate
, a process called pyruvate decarboxylation. A large study by Fluge
of 200 patients meeting the Canadian Consensus Criteria
and 102 controls found a pattern of amino acids that suggested functional impairment of pyruvate dehydrogenase (PDH), supported by increased mRNA expression of the inhibitory PDH kinases 1, 2, and 4; sirtuin 4; and PPARδ in peripheral blood mononuclear cells from both sexes. (more...
Two-day cardiopulmonary exercise testing
or 2-day CPET
is a of post-exertional malaise
(PEM), one of the cardinal symptoms that distinguishes between individuals with and without ME/CFS
. The hypothesis is that ME/CFS patients are almost unique in having a severe deterioration in the second of the two cardiopulmonary exercise tests performed on consecutive days. The test is also frequently used in research to compare outcomes pre- and post- exercise. (more...
is marked by a significant decrease in the ability to sustain exercise
and, often, to engage in it altogether. Exercise induces abnormal gene expression, bacterial translocation, lactic acid build-up, and oxidative impairment in patients. (more...