Portal:Energy metabolism
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Energy metabolism
Abnormalities in energy metabolism and exercise intolerance are key features of myalgic encephalomyelitis, whose cardinal symptom is post-exertional malaise. (more...)
Selected article
Pyruvate dehydrogenase (PDH) is an enzyme that is part of the citric acid cycle. It catalyzes the reaction that transforms pyruvate into acetyl-CoA, a process called pyruvate decarboxylation. A large study by Fluge and Mella of 200 patients meeting the Canadian Consensus Criteria and 102 controls found a pattern of amino acids that suggested functional impairment of pyruvate dehydrogenase (PDH), supported by increased mRNA expression of the inhibitory PDH kinases 1, 2, and 4; sirtuin 4; and PPARδ in peripheral blood mononuclear cells from both sexes. (more...)
Selected biography
Christopher William Armstrong, is a post doctorate student in the Department of Biochemistry and Molecular Biology and a Bio21 Molecular Science & Biotechnology Institute researcher at the University of Melbourne, Melbourne, Australia with an interest in the dysfunction of energy metabolism of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (more...)
Topics
- ATP-Dependent RNA Helicase DDX51
- Cell danger response hypothesis
- Cellular respiration
- Glycolysis
- Ketosis
- Kynurenine
- Lactic acid
- Lactic acidosis
- Metabolic
- Metabolic features of chronic fatigue syndrome
- Metabolomics
- Mitochondrial disorder
- Peroxisome
- Category:Anaerobic respiration
- Category:Beta-oxidation
- Category:Cellular respiration
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