Nitrogen hypothesis

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

The nitrogen hypothesis or nitrogen metabolism hypothesis of ME/CFS was first proposed by Christopher Armstrong in 2018.[1]

Theory[edit | edit source]

According to the Open Medicine Foundation, the nitrogen hypothesis states that: "nitrogen-containing by-products of energy production accumulate more readily in the cells of people with ME / CFS, these nitrogen-containing by-products can be damaging to the cells and their process of producing energy".[1]

Evidence[edit | edit source]

In 2020, the Open Medicine Foundation announced that Christopher Armstrong had been awarded a grant to investigate the nitrogen hypothesis at the Open Medicine Foundation's ME/CFS Collaborative Research Center at Stanford University, run by the Dr. Ron Davis.[1]

In Aug 2020, the Open Medicine Foundation stated "Armstrong first noted increased usage of amino acids, which contains nitrogen, in the metabolism of people with ME/CFS while working at the University of Melbourne. He was the first to apply metabolomics to the field of ME/CFS, publishing his results in 2015. Metabolomics is the study of small molecules (metabolites) using common standards of detection that enable different studies to be comparative and additive."[1]

Treatment[edit | edit source]

None has been proposed yet.

Articles and blogs[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 "Grant Awarded to Nitrogen Hypothesis Study". Open Medicine Foundation. August 29, 2020. Retrieved August 29, 2020.