Nitric oxide hypothesis

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(Redirected from NO/ONOO cycle)

The NO/ONOO cycle (pronounced no/oh no) is also known as the nitric oxide cycle theory, is a hypothesis developed by Dr Martin Pall.

Theory[edit | edit source]

Dr Martin L. Pall states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radicals to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."[1]

Evidence[edit | edit source]

Notable studies[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]