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Nitric oxide hypothesis
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
The NO/ONOO cycle (pronounced no/oh no) is also known as the nitric oxide cycle theory, is a hypothesis developed by Dr Martin Pall.
Theory[edit | edit source]
Dr Martin L. Pall states: "I propose here a novel hypothesis of CFS in which either viral or bacterial infection induces one or more cytokines, IL-1beta IL-6, TNF-alpha and IFN-gamma. These induce nitric oxide synthase (iNOS), leading to increased nitric oxide levels. Nitric oxide, in turn, reacts with superoxide radicals to generate the potent oxidant peroxynitrite. Multiple amplification and positive feedback mechanisms are proposed by which once peroxynitrite levels are elevated, they tend to be sustained at a high level."[1]
Evidence[edit | edit source]
Notable studies[edit | edit source]
Learn more[edit | edit source]
- How Can We Cure NO/ONOO− Cycle Diseases?, Martin L. Pall, 2010
- Nitric oxide and its possible implication in ME/CFS (Part 1 of 2), Phoenix Rising, August 25, 2014
- Nitric oxide and its possible implication in ME/CFS (Part 2 of 2), Phoenix Rising, August 28, 2014
- Nitric oxide - Encyclopaedia of Neuroscience
- Fluge/Mella Take out Patent on Nitric Oxide Treatment for ME/CFS, Health Rising, Jul 31, 2015
See also[edit | edit source]
References[edit | edit source]
- ↑ Pall, Martin L. (January 2000). "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome". Medical Hypotheses. 54 (1): 115–125. doi:10.1054/mehy.1998.0825. ISSN 0306-9877. PMID 10790736.
