Martin Pall

Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A. He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.

Dr. Pall was one of the authors of the 2011 case definition, the International Consensus Criteria.

Education

• 1962 - B.A., Johns Hopkins University, Baltimore, MD
• 1968 - Ph.D., California Institute of Technology, Pasadena, CA

NO/ONOO-cycle

Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.

He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle. He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.

Book

• 2007, Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome

Articles

• 2007, Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD
• 2009, Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS
• 2010, How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter

Talks and interviews

• 2007, "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"
• 2007, Speaker at the 2nd Invest in ME International ME Conference - Biochemical Underpinnings of ME/CFS - (Video)
• 2014, Martin Pall explains "Unexplained Illnesses" (English with French subtitles)

Publications on ME/CFS

• 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome - (Abstract)
• 2000, Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation - (Abstract)
• 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger - (Abstract)
• 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite - (Full text)
• 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder - (Abstract)
• 2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients - (Abstract)
• 2002, Chronic fatigue syndrome/myalgic encephalitis - (Full access)
• 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients - (Abstract)
• 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due - (Abstract)
• 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease - (Abstract)
• 2011, Myalgic encephalomyelitis: International Consensus Criteria - (Full text)
• 2011, Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? - (Abstract)

Online presence

• ResearchGate

See also

• Anna Dorothea Hoeck
• N-acetylcysteine
• Nitric oxide hypothesis

See chronic fatigue syndrome.

See ME/CFS.

See myalgic encephalomyelitis.

etiology The cause of origin, especially of a disease.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.