Cobalamin
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(Redirected from Vitamin B12)
Vitamin B12, also known as cobalamin, is a water-soluble vitamin, one of the B vitamins. Forms of cobalamin include hydroxo-cobalamin, cyano-cobalamin, methyl-cobalamin, and adenosyl-cobalamin.
Physiology[edit | edit source]
B12 is involved in cellular metabolism and formation of red blood cells (RBCs). It has an integral role in brain and nervous system function. Absorption of B12 from dietary sources requires an intrinsic factor (IF or GIF), i.e., a glycoprotein, synthesized in and secreted from parietal cells in the lining of the human stomach.
Immune system[edit | edit source]
Vitamin B12 deficiency may be associated with decreased natural killer cell activity.[1]
ME/CFS[edit | edit source]
Deficiency[edit | edit source]
Notable studies[edit | edit source]
- 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger [2] (Abstract)
- 2015, Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia[3] (Full Text)
See also[edit | edit source]
- Vitamin B12 deficiency
- Vitamin
- B vitamins
- B vitamin complex
- Malnutrition
- Martin Pall
- Carl-Gerhard Gottfries
Learn more[edit | edit source]
- Linus Pauling Institute Micronutrient Information Center - Vitamin B12
- B12 - rationale for using vitamin B12 in CFS - Dr. Sarah Myhill
References[edit | edit source]
- ↑ Tamura, J.; Kubota, K.; Murakami, H.; Sawamura, M.; Matsushima, T.; Tamura, T.; Saitoh, T.; Kurabayshi, H.; Naruse, T. (April 1, 1999), "Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment", Clinical & Experimental Immunology, 116 (1): 28–32, doi:10.1046/j.1365-2249.1999.00870.x, ISSN 1365-2249, retrieved November 9, 2016
- ↑ Pall, Martin L. (2000). Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger. Journal of Chronic Fatigue Syndrome, Vol. 8, Iss. 2, pp. 39-44. doi: 10.1300/J092v08n02_04
- ↑ Regland, Björn; Forsmark, Sara; Halaouate, Lena; Matousek, Michael; Peilot, Birgitta; Zachrisson, Olof; Gottfries, Carl-Gerhard (2015), "Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.", PLoS ONE, 10 (4), doi:10.1371/journal.pone.0124648
