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Vitamin B12, also known as cobalamin, is a water-soluble vitamin, one of the B vitamins. Forms of cobalamin include hydroxo-cobalamin, cyano-cobalamin, methyl-cobalamin, and adenosyl-cobalamin.

Physiology[edit | edit source]

B12 is involved in cellular metabolism and formation of red blood cells (RBCs). It has an integral role in brain and nervous system function. Absorption of B12 from dietary sources requires an intrinsic factor (IF or GIF), i.e., a glycoprotein, synthesized in and secreted from parietal cells in the lining of the human stomach.

Immune system[edit | edit source]

Vitamin B12 deficiency may be associated with decreased natural killer cell activity.[1]

ME/CFS[edit | edit source]

Deficiency[edit | edit source]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Tamura, J.; Kubota, K.; Murakami, H.; Sawamura, M.; Matsushima, T.; Tamura, T.; Saitoh, T.; Kurabayshi, H.; Naruse, T. (April 1, 1999), "Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment", Clinical & Experimental Immunology, 116 (1): 28–32, doi:10.1046/j.1365-2249.1999.00870.x, ISSN 1365-2249, retrieved November 9, 2016
  2. Pall, Martin L. (2000). Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger. Journal of Chronic Fatigue Syndrome, Vol. 8, Iss. 2, pp. 39-44. doi: 10.1300/J092v08n02_04
  3. Regland, Björn; Forsmark, Sara; Halaouate, Lena; Matousek, Michael; Peilot, Birgitta; Zachrisson, Olof; Gottfries, Carl-Gerhard (2015), "Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.", PLoS ONE, 10 (4), doi:10.1371/journal.pone.0124648