Pyrroloquinoline Quinone
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
 | This article is a stub. |
Pyrroloquinoline Quinone or PQQ occurs normally in human tissue and certain plants, and is available as a natural supplement.[1][2] PQQ is believed to induce mitochondrial biogenesis.[2]
Potential uses[edit | edit source]
No established uses, although it has antioxidant, anti-inflammatory and neuroprotective effects and may help with mitochondrion dysfunction and help modulate energy metabolism.[2]
Cusack Protocol[edit | edit source]
The Cusack Protocol, which was devised for Ehlers-Danlos syndrome involves using eight different supplements, including PQQ.[3][4]
Evidence[edit | edit source]
[1] No clinical trials of PQQ have involved ME/CFS patients.[2]
Risks and safety[edit | edit source]
Based on limited studies, PQQ appears to be safe, although this has not been confirmed in patients with ME/CFS.[2]
Costs and availability[edit | edit source]
PQQ is available over the counter.
Notable studies[edit | edit source]
- 2018, Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements[2] - (Book chapter)
- 2013, Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects[1] - (Full text)]
Learn more[edit | edit source]
- Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects - Harris et al. (2013)
See also[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 Harris, Calliandra B.; Winyoo, Chowanadisai; Mishchuk, Darya O.; Satre, Mike A.; Slupsky, Carolyn M.; Rucker, Robert B. (December 1, 2013). "Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects". The Journal of Nutritional Biochemistry. 24 (12): 2076–2084. doi:10.1016/j.jnutbio.2013.07.008. ISSN 0955-2863.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Nicolson, Garth L.; Ferreira, Gonzalo; Settineri, Robert; Ellithorpe, Rita R.; Breeding, Paul; Ash, Michael E. (2018). "Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements". In Oliveira, Paulo J. (ed.). Mitochondrial Biology and Experimental Therapeutics. Cham: Springer. pp. 499–522. doi:10.1007/978-3-319-73344-9_22. ISBN 978-3-319-73344-9.
- ↑ Cusack, Deborah. "What Works?". EDS and Polysaccharides. Retrieved October 4, 2020.
- ↑ Ehlers-Danlos Support Wilmington (March 10, 2016). "Cusack Protocol (slides)". facebook.com.
