Lactate dehydrogenase

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Lactate dehydrogenase (LDH) converts lactic acid to pyruvate and back.

Increased serum concentrations of LDH have been found in ME patients during the acute phase.[1]

Abnormally high LDH was found in patients of the 1955 Royal Free Hospital outbreak.[2]

One study on 579 CDC-criteria CFS patients found lower levels of LDH relative to controls.[3]

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  1. Fegan, KG; Behan, PO; Bell, EJ (June 1983), "Myalgic encephalomyelitis--report of an epidemic.", J R Coll Gen Pract, 33 (251): 335–337, PMID 6310104
  2. Ramsay, A. Melvin (November 1978). "'Epidemic neuromyasthenia' 1955-1978". Postgraduate Medical Journal. 54: 718–721.
  3. Bates, David W.; Buchwald, Dedra; Lee, Joshua; Kith, Phalla; Doolittle, Teresa; Rutherford, Cynthia; Churchill, W. Hallowell; Schur, Peter H.; Wener, Mark; Wybenga, Donald; Winkelman, James (January 9, 1995). "Clinical Laboratory Test Findings in Patients With Chronic Fatigue Syndrome". Archives of Internal Medicine. 155 (1): 97–103. doi:10.1001/archinte.1995.00430010105014. ISSN 0003-9926.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.