Red blood cell

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Red blood cells (RBCs), or erythrocytes, are the most common type of blood cell in the human body.

Discoctyes are normally shaped red blood cells and stomatocytes are cup-shaped red blood cells[1] which may appear to have a slit shape in the center, like a coffee bean.

In ME/CFS[edit | edit source]

Red blood cell shapes. Cup-shaped stomatocytes, next to normal biconcave discoctyes.[https://link.springer.com/article/10.1007/s12195-008-0019-5 Citation: Khairy, K., Foo, J. & Howard, J. Cel. Mol. Bioeng. (2008) 1: 173.

Red blood cell abnormalities have been found in patients with chronic fatigue syndrome and Gulf War Illness

A small study of veterans with Gulf War Illness found increased deformability (the ability of erythrocytes to change shape under a given level of applied stress without rupturing) along with increased mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell distribution width (RDW).[2]

A 1989 study found higher numbers of cup-form red blood cells known as stomatocytes in ME patients versus controls.[3]

Studies[edit | edit source]

  • 1989, Red blood cell morphology in chronic fatigue syndrome.[4]
  • 1991, Red blood cell magnesium and chronic fatigue syndrome.[5]
  • 1994, Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome.[6]
  • 2004, Autonomic function and serum erythropoietin levels in chronic fatigue syndrome.[7]
  • 2018, Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome.[8]
  • 2018, Abnormal rheological properties of red blood cells as a potential marker of Gulf War Illness: A preliminary study.[2]

See also[edit | edit source]

References[edit | edit source]

  1. Khairy, Khaled; Foo, JiJinn; Howard, Jonathon (September 3, 2008). "Shapes of Red Blood Cells: Comparison of 3D Confocal Images with the Bilayer-Couple Model". Cellular and Molecular Bioengineering. 1 (2): 173. doi:10.1007/s12195-008-0019-5. ISSN 1865-5033. PMC 2963995. PMID 21031149.
  2. 2.02.1 Falvo, Michael J.; Chen, Yang; Klein, Jacquelyn C.; Ndirangu, Duncan; Condon, Michael R. (2018). "Abnormal rheological properties of red blood cells as a potential marker of Gulf War Illness: A preliminary study". Clinical Hemorheology and Microcirculation. 68 (4): 361–370. doi:10.3233/CH-170262. ISSN 1875-8622. PMID 29660926.
  3. Simpson, LO (1989), "Nondiscocytic erythrocytes in myalgic encephalomyelitis", The New Zealand Medical Journal, 102 (864): 126-127, PMID 2927808
  4. Lloyd, A.; Wakefield, D.; Smith, L.; Isbister, J.; McGrath, M.; Collings, A.; Bajenov, N. (July 22, 1989). "Red blood cell morphology in chronic fatigue syndrome". Lancet (London, England). 2 (8656): 217. ISSN 0140-6736. PMID 2568543.
  5. Cox, I. M.; Campbell, M. J.; Dowson, D. (March 30, 1991). "Red blood cell magnesium and chronic fatigue syndrome". Lancet (London, England). 337 (8744): 757–760. ISSN 0140-6736. PMID 1672392.
  6. Hinds, G.; Bell, N. P.; McMaster, D.; McCluskey, D. R. (September 1994). "Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome". Annals of Clinical Biochemistry. 31 (Pt 5): 459–461. doi:10.1177/000456329403100506. ISSN 0004-5632. PMID 7832571.
  7. Winkler, Andrea S.; Blair, Dorothy; Marsden, Joanne T.; Peters, Timothy J.; Wessely, Simon; Cleare, Anthony J. (February 2004). "Autonomic function and serum erythropoietin levels in chronic fatigue syndrome". Journal of Psychosomatic Research. 56 (2): 179–183. doi:10.1016/S0022-3999(03)00543-9. ISSN 0022-3999. PMID 15016575.
  8. Saha, Amit K.; Schmidt, Brendan R.; Wilhelmy, Julie; Nguyen, Vy; Abugherir, Abed; Do, Justin K.; Nemat-Gorgani, Mohsen; Davis, Ronald W.; Ramasubramanian, Anand K. (December 28, 2018). "Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome". Clinical Hemorheology and Microcirculation. doi:10.3233/CH-180469. ISSN 1875-8622. PMID 30594919.

morphology The form and structure of plants and animals. A branch of biology.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience. Although "Somatic Symptom Disorder" is the term used by DSM-5, the term "Bodily Distress Disorder" has been proposed for ICD-11. (Learn more: www.psychologytoday.com)

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.