Immunoglobulin A
Immuglobulin A or IgA is an antibody that plays a crucial role in mucosal immunity.
It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.
Function[edit | edit source]
IgA is considered the first line for defense against infections.[1]
ME/CFS[edit | edit source]
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[2]
Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[3]
See also[edit | edit source]
Learn more[edit | edit source]
- Immunoglobulin A - British Society for Immunology
- The Adaptive Immune Response: B-lymphocytes and Antibodies
References[edit | edit source]
- ↑ "Immunoglobulin A (IgA)". British Society for Immunology. Retrieved March 23, 2021.
- ↑ Maes, Michael; Twisk, Frank N; Kubera, M; Ringel, K; Leunis, JC; Geffard, M (October 2, 2011). "Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome". J Affect Disord. 136 (3): 909–17. doi:10.1016/j.jad.2011.09.010. PMID 21967891.
- ↑ Maes, Michael; Mihaylova, I; Leunis, JC (September 27, 2006). "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability". J Affect Disord. 99 (1–3): 237–40. doi:10.1016/j.jad.2006.08.021. PMID 17007934.
