Immunoglobulin A
Immuglobulin A (IgA) is an antibody that plays a crucial role in mucosal immunity.
It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.
Chronic fatigue syndrome[edit | edit source]
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[1]
Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[2]
Learn more[edit | edit source]
- Immunoglobulin A, Wikipedia
References[edit | edit source]
- ↑ Maes, Michael; Twisk, Frank N; Kubera, M; Ringel, K; Leunis, JC; Geffard, M (Oct 2, 2011), "Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome", J Affect Disord, 2012 Feb;136(3): 909-17, doi:10.1016/j.jad.2011.09.010, PMID 21967891
- ↑ Maes, Michael; Mihaylova, I; Leunis, JC (Sep 27, 2006), "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability", J Affect Disord, 2007 Apr;99(1-3): 237-40, doi:10.1016/j.jad.2006.08.021, PMID 17007934
Myalgic encephalomyelitis or chronic fatigue syndrome, often used when both illnesses are considered the same.
The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.
