Immunoglobulin A
Immuglobulin A (IgA) is an antibody that plays a crucial role in mucosal immunity.
It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.
Chronic fatigue syndrome[edit | edit source]
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[1]
Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[2]
Learn more[edit | edit source]
- Immunoglobulin A, Wikipedia
References[edit | edit source]
- ↑ Maes, Michael; Twisk, Frank N; Kubera, M; Ringel, K; Leunis, JC; Geffard, M (Oct 2, 2011), "Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome", J Affect Disord, 2012 Feb;136(3): 909-17, doi:10.1016/j.jad.2011.09.010, PMID 21967891
- ↑ Maes, Michael; Mihaylova, I; Leunis, JC (Sep 27, 2006), "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability", J Affect Disord, 2007 Apr;99(1-3): 237-40, doi:10.1016/j.jad.2006.08.021, PMID 17007934
antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.
serum - The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)
serum - The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)
The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.
