Immunoglobulin A
Immuglobulin A or IgA is an antibody that plays a crucial role in mucosal immunity.
It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.
Contents
Function[edit | edit source]
IgA is considered the first line for defense against infections.[1]
ME/CFS[edit | edit source]
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[2]
Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[3]
See also[edit | edit source]
Learn more[edit | edit source]
- Immunoglobulin A - British Society for Immunology
- The Adaptive Immune Response: B-lymphocytes and Antibodies
References[edit | edit source]
- ↑ "Immunoglobulin A (IgA)". British Society for Immunology. Retrieved March 23, 2021.
- ↑ Maes, Michael; Twisk, Frank N; Kubera, M; Ringel, K; Leunis, JC; Geffard, M (October 2, 2011), "Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome", J Affect Disord, 136 (3): 909-17, doi:10.1016/j.jad.2011.09.010, PMID 21967891
- ↑ Maes, Michael; Mihaylova, I; Leunis, JC (September 27, 2006), "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability", J Affect Disord, 99 (1–3): 237-40, doi:10.1016/j.jad.2006.08.021, PMID 17007934
antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)
serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)
The information provided at this site is not intended to diagnose or treat any illness.
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