Immunoglobulin A

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Immuglobulin A (IgA) is an antibody that plays a crucial role in mucosal immunity.

It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.

Chronic fatigue syndrome[edit | edit source]

A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[1]

Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[2]

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References[edit | edit source]

Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response. [1]

Myalgic encephalomyelitis or chronic fatigue syndrome, often used when both illnesses are considered the same.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.