Immunoglobulin A

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Immuglobulin A (IgA) is an antibody that plays a crucial role in mucosal immunity.

It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.

Chronic fatigue syndrome[edit | edit source]

A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[1]

Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[2]

Learn more[edit | edit source]

References[edit | edit source]

Myalgic encephalomyelitis or chronic fatigue syndrome


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history