Immunoglobulin A
Immuglobulin A (IgA) is an antibody that plays a crucial role in mucosal immunity.
It is the main immunoglobulin found in mucous secretions including the gastrointestinal tract.
Chronic fatigue syndrome[edit | edit source]
A study of 128 ME/CFS patients found significantly increased IgA response to lipopolysaccharides (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum IL-1, TNFα, neopterin and elastase. The study concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.[1]
Another study found elevated serum concentrations of both IgA and IgM to LPS of gram-negative bacteria. Serum IgA levels correlated with illness severity as measured by the FibroFatigue scale[2]
Learn more[edit | edit source]
- Immunoglobulin A, Wikipedia
References[edit | edit source]
- ↑ Maes, Michael; Twisk, Frank N; Kubera, M; Ringel, K; Leunis, JC; Geffard, M (Oct 2, 2011), "Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome", J Affect Disord, 2012 Feb;136(3): 909-17, doi:10.1016/j.jad.2011.09.010, PMID 21967891
- ↑ Maes, Michael; Mihaylova, I; Leunis, JC (Sep 27, 2006), "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability", J Affect Disord, 2007 Apr;99(1-3): 237-40, doi:10.1016/j.jad.2006.08.021, PMID 17007934
Myalgic encephalomyelitis or chronic fatigue syndrome
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
