Julia Newton

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Julia L. Newton is a Clinical Professor of Ageing and Medicine at the University of Newcastle in the United Kingdom. She has published a number of ME/CFS studies focusing on autonomic nervous system dysfunction[1] and the role of inflammation in fatigue. She is a member of the UK CFS/ME Collaborative and is the Joint Medical Adviser of the charity Action for ME.

She is Director of the Newcastle Fatigue Research Group [2] and Associate Medical Director for Research for Newcastle upon Tyne Hospitals NHS Foundation Trust.

Dr. Newton serves on the editorial board of the journal, Fatigue: Biomedicine, Health & Behavior, published on behalf of the IACFS/ME.[3]

Notable studies[edit | edit source]

Talks and interviews[edit | edit source]

Talks for Dutch ME/CFS Society

2014, Playlist on YouTube containing:

Invest in ME International ME Conferences

  • 2008, Speaker at the 3rd Invest in ME International ME Conference on Autonomic Dysfunction: Identification of aetiologically distinct subject groups within ME/CFS[57] - (Video)
  • 2014, Speaker at the 9th Invest in ME International ME Conference [58] DVD available

Learn more[edit | edit source]

Online presence[edit | edit source]

References[edit | edit source]

  1. ↑ "Staff Profile - Institute of Cellular Medicine". Newcastle University. Retrieved August 10, 2018.
  2. ↑ "Fatigue Research - Faculty of Medical Sciences - Newcastle University". ncl.ac.uk. Retrieved August 10, 2018.
  3. ↑ "Fatigue: Biomedicine, Health & Behavior". tandfonline.com. Retrieved November 1, 2019.
  4. ↑ Hoad, A.; Spickett, G.; Elliott, J.; Newton, J. (2008). "Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome". QJM: monthly journal of the Association of Physicians. 101 (12): 961–965. doi:10.1093/qjmed/hcn123. ISSN 1460-2393. PMID 18805903.
  5. ↑ Newton, Julia L.; Sheth, Amish; Shin, Jane; Pairman, Jessie; Wilton, Katharine; Burt, Jennifer A.; Jones, David E.J. (April 2009). "Lower Ambulatory Blood Pressure in Chronic Fatigue Syndrome". Psychosomatic Medicine. 71 (3): 361–365. doi:10.1097/psy.0b013e31819ccd2a. ISSN 0033-3174.
  6. ↑ Hollingsworth, Kieren G.; Jones, David E.J.; Taylor, Roy; Blamire, Andrew M.; Newton, Julia L. (May 17, 2010). "Impaired cardiovascular response to standing in Chronic Fatigue Syndrome". European Journal of Clinical Investigation. 40 (7): 608–615. doi:10.1111/j.1365-2362.2010.02310.x. ISSN 0014-2972.
  7. ↑ Newton, JL; Mabillard, H; Scott, A; Hoad, A; Spickett, G (December 1, 2010). "The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same" (PDF). The Journal of the Royal College of Physicians of Edinburgh. 40 (4): 304–307. doi:10.4997/jrcpe.2010.404. ISSN 1478-2715.
  8. ↑ Jones, David E.J.; Hollingsworth, Kieren G.; Jakovljevic, Djordje G.; Fattakhova, Gulnar; Pairman, Jessie; Blamire, Andrew M.; Trenell, Michael I.; Newton, Julia L. (2011), "Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case–control study", European Journal of Clinical Investigation, 42 (2), doi:10.1111/j.1365-2362.2011.02567.x
  9. ↑ Hollingsworth, KG; Hodgson, T; MacGowan, GA; Blamire, AM; Newton, JL (2012), "Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance cardiac tagging", Journal of Internal Medicine, 271: 264–270, doi:10.1111/j.1365-2796.2011.02429.x
  10. ↑ Frith, J.; Zalewski, P.; Klawe, J.J.; Pairman, J.; Bitner, A.; Tafil-Klawe, M.; Newton, J.L. (September 1, 2012). "Impaired blood pressure variability in chronic fatigue syndrome—a potential biomarker". QJM: An International Journal of Medicine. 105 (9): 831–838. doi:10.1093/qjmed/hcs085. ISSN 1460-2725.
  11. ↑ He, Jiabao; Hollingsworth, Kieren G.; Newton, Julia L.; Blamire, Andrew M. (2013), "Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation", NeuroImage: Clinical, 2: 168-173, doi:10.1016/j.nicl.2012.12.006
  12. ↑ Jason, LA; Brown, A; Evans, M; Sunnquist, M; Newton, JL (2013), "Contrasting chronic fatigue syndrome versus myalgic encephalomyelitis/chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, 1 (3): 168-183, doi:10.1080/21641846.2013.774556
  13. ↑ Gotts, Z.M.; Ellis, J.G.; Newton, Julia L.; Deary, V. (2014), "The role of sleep in chronic fatigue syndrome: a narrative review", Fatigue: Biomedicine, Health & Behavior, 2 (3): 163-184, doi:10.1080/21641846.2014.935607
  14. ↑ Robinson, Lucy J.; Durham, Justin; MacLachlan, Laura L.; Newton, Julia L. (October 2, 2015). "Autonomic function in chronic fatigue syndrome with and without painful temporomandibular disorder". Fatigue: Biomedicine, Health & Behavior. 3 (4): 205–219. doi:10.1080/21641846.2015.1091152. ISSN 2164-1846.
  15. ↑ Jason, L.A.; Sunnquist, M.; Brown, A.; Newton, J.L.; Strand, E.B.; Vernon, S.D. (2015), "Chronic fatigue syndrome versus systemic exertion intolerance disease", Fatigue: Biomedicine, Health & Behavior, 3 (3): 127-141, doi:10.1080/21641846.2015.1051291
  16. ↑ Jason, Leonard A; Sunnquist, Madison; Brown, Abigail; Furst, Jacob; Cid, Marjoe; Farietta, Jillianna; Kot, Bobby; Bloomer, Craig; Nicholson, Laura; Williams, Yolonda; Jantke, Rachel; Newton, Julia L; Strand, Elin Bolle (2015), "Factor Analysis of the DePaul Symptom Questionnaire: Identifying Core Domains", Journal of Neurology and Neurobiology, 1 (4), doi:10.16966/2379-7150.114
  17. ↑ Brown, Audrey E.; Jones, David E.; Walker, Mark; Newton, Julia L. (2015), "Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome", PLoS One, 10 (4), doi:10.1371/journal.pone.0122982
  18. ↑ Jason, LA; Kot, B; Sunnquist, M; Brown, A; Reed, J; Furst, J; Newton, JL; Strand, EB; Vernon, SD (2015), "Comparing and Contrasting Consensus versus Empirical Domains", Fatigue: biomedicine, health & behavior, 3 (2): 63-74, doi:10.1080/21641846.2015.1017344, PMID 26977374
  19. ↑ Rutherford, Gina; Manning, Philip; Newton, Julia L. (2016), "Understanding Muscle Dysfunction in Chronic Fatigue Syndrome", Journal of Aging Research, doi:10.1155/2016/2497348
  20. ↑ Gotts, Zoe; Deary, Vincent; Newton, Julia; Ellis, Jason (2016), "Treatment of insomnia reduces fatigue in chronic fatigue syndrome in those able to comply with the intervention", Fatigue: Biomedicine, Health & Behavior, 4 (4): 208-216, doi:10.1080/21641846.2016.1222699
  21. ↑ Pendergrast, Tricia; Brown, Abigail; Sunnquist, Madison; Jantke, Rachel L.; Newton, Julia L.; Strand, Elin Bolle; Jason, Leonard A. (2016), "Housebound versus nonhousebound patients with myalgic encephalomyelitis and chronic fatigue syndrome", Chronic Illness, doi:10.1177/1742395316644770
  22. ↑ Thorpe, Taylor; McManimen, Stephanie; Gleason, Kristen; Stoothoff, Jamie; Newton, Julia L.; Strand, Elin Bolle; Jason, Leonard A. (2016), "Assessing current functioning as a measure of significant reduction in activity level", Fatigue: Biomedicine, Health & Behavior, 4 (3): 175-188, doi:10.1080/21641846.2016.1206176
  23. ↑ Kidd, Elizabeth; Brown, Abigail; McManimen, Stephanie; Jason, Leonard A.; Newton, Julia L.; Strand, Elin B. (2016), "The Relationship between Age and Illness Duration in Chronic Fatigue Syndrome", Diagnostics, 6 (2): 16, doi:10.3390/diagnostics6020016
  24. ↑ Newton, Julia L.; Finkelmeyer, Andreas; Petrides, George; Frith, James; Hodgson, Tim; Maclachlan, Laura; MacGowan, Guy; Blamire, Andrew M. (2016), "Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study", Open Heart, 3 (1), doi:10.1136/openhrt-2015-000381
  25. ↑ Clark, James E.; Ng, W. Fai; Watson, Stuart; Newton, Julia L. (2016), "The aetiopathogenesis of fatigue: unpredictable, complex and persistent", British Medical Bulletin, 2016 (117): 139–148, doi:10.1093/bmb/ldv057
  26. ↑ Gotts, Z.M.; Deary, V.; Newton, Julia L.; Ellis, J.G. (2016), "A comparative polysomnography analysis of sleep in healthy controls and patients with chronic fatigue syndrome.", Fatigue: Biomedicine, Health & Behavior, 4 (2): 80-93, doi:10.1080/21641846.2016.1167470
  27. ↑ Jason, L. A.; McManimen, S.; Sunnquist, Madison; Brown, A.; Furst, J.; Newton, J.L.; Strand, E. B. (2016), "Case definitions integrating empiric and consensus perspectives", Fatigue: Biomedicine, Health & Behavior, 4 (1): 1-23, doi:10.1080/21641846.2015.1124520
  28. ↑ Jason, Leonard A; Sunnquist, Madison; Brown, Abigail; Evans, Meredyth; Newton, Julia L (2016), "Are Myalgic Encephalomyelitis and chronic fatigue syndrome different illnesses? A preliminary analysis", Journal of Health Psychology, 21 (1): 3-15, doi:10.1177/1359105313520335
  29. ↑ Jason, Leonard A; McManimen, Stephanie; Sunnquist, Madison; Newton, Julia L; Strand, Elin Bolle (2017), "Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia", ECronicon, 5 (1): 19-28, PMID 28713879
  30. ↑ Maclachlan, Laura; Watson, Stuart; Gallagher, Peter; Finkelmeyer, Andreas; Jason, Leonard A.; Sunnquist, Madison; Newton, Julia L. (2017), "Are current chronic fatigue syndrome criteria diagnosing different disease phenotypes?", PLOS One, doi:10.1371/journal.pone.0186885
  31. ↑ Tomas, Cara; Finkelmeyer, Andreas; Hodgson, Tim; MacLachlan, Laura; MacGowan, Guy A; Blamire, Andrew M; Newton, Julia L (2017), "Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study", Open Heart, doi:10.1136/openhrt-2017-000697
  32. ↑ Strassheim, Victoria; Lambson, Rebecca; Hackett, Katie L.; Newton, Julia L. (July 3, 2017). "What is known about severe and very severe chronic fatigue syndrome? A scoping review". Fatigue: Biomedicine, Health & Behavior. 5 (3): 167–183. doi:10.1080/21641846.2017.1333185. ISSN 2164-1846.
  33. ↑ Jason, LA; McManimen, S; Sunnquist, M; Newton, JL; Strand, EB (2017), "Clinical criteria versus a possible research case definition in chronic fatigue syndrome/myalgic encephalomyelitis", Fatigue: biomedicine, health & behavior, doi:10.1080/21641846.2017.1299077
  34. ↑ Davidson, Sean L.; Gotts, Zoe M.; Ellis, Jason G.; Newton, Julia L. (March 2017), "Two year follow-up of sleep diaries and polysomnography in chronic fatigue syndrome: a cohort study", Fatigue: Biomedicine, Health & Behavior, doi:10.1080/21641846.2017.1297280
  35. ↑ O'Connor, Kelly; Sunnquist, Madison; Nicholson, Laura; Jason, Leonard A; Newton, Julia L; Strand, Elin B (December 12, 2017). "Energy envelope maintenance among patients with myalgic encephalomyelitis and chronic fatigue syndrome: Implications of limited energy reserves". Chronic Illness: 174239531774647. doi:10.1177/1742395317746470. ISSN 1742-3953. PMID 29231037.
  36. ↑ Tomas, Cara; Brown, Audrey; Strassheim, Victoria; Elson, Joanna; Newton, Julia; Manning, Philip (October 24, 2017). "Cellular bioenergetics is impaired in patients with chronic fatigue syndrome". PLOS ONE. 12 (10): e0186802. doi:10.1371/journal.pone.0186802. ISSN 1932-6203. PMID 29065167.
  37. ↑ Schoeman, Elizna M.; Van Der Westhuizen, Francois H.; Erasmus, Elardus; van Dyk, Etresia; Knowles, Charlotte V.Y.; Al-Ali, Shereen; Ng, Wan-Fai; Taylor, Robert W.; Newton, Julia L. (March 16, 2017). "Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome". BMC Medical Genetics. 18 (1). doi:10.1186/s12881-017-0387-6. ISSN 1471-2350. PMID 28302057.
  38. ↑ Zalewski, Pawel; Finkelmeyer, Andreas; Frith, James; = Maclachlan, Laura; Blamire, Andrew; Newton, Julia L. (2018). "Liver volume is lower and associates with resting and dynamic blood pressure variability in chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 6 (3): 141-152. doi:10.1080/21641846.2018.1488525.
  39. ↑ Tomas, Cara; Newton, Julia L (2018), "Metabolic abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a mini-review", Biochemical Society Transactions, doi:10.1042/BST20170503, PMID 29666214
  40. ↑ Brown, Audrey E; Dibnah, Beth; Fisher, Emily; Newton, Julia L; Walker, Mark (2018), "Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS", Bioscience Reports, 38 (3): BSR20180242, doi:10.1042/BSR20180242, PMC 5938427, PMID 29654166
  41. ↑ Strassheim, Victoria; Welford, Jenny; Ballantine, Rob; Newton, Julia L. (December 2018). "Managing fatigue in postural tachycardia syndrome (PoTS): The Newcastle approach". Autonomic Neuroscience. 215: 56–61. doi:10.1016/j.autneu.2018.02.003.
  42. ↑ Clark, James E.; Davidson, Sean L.; Maclachlan, Laura; Newton, Julia L.; Watson, Stuart (2017), "Rethinking childhood adversity in chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, doi:10.1080/21641846.2018.1384095
  43. ↑ Finkelmeyer, Andreas; He, Jiabao; Maclachlan, Laura; Watson, Stuart; Gallagher, Peter; Newton, Julia L.; Blamire, Andrew M. (2018), "Grey and white matter differences in Chronic Fatigue Syndrome – A voxel-based morphometry study", NeuroImage: Clinical, 17: 24-30, doi:10.1016/j.nicl.2017.09.024, PMID 29021956
  44. ↑ Lynn, Megan; Maclachlan, Laura; Finkelmeyer, Andreas; Clark, James; Locke, James; Todryk, Stephen; Ng, Wan-Fai; Newton, Julia L.; Watson, Stuart (2018). "Reduction of glucocorticoid receptor function in Chronic Fatigue Syndrome". Mediators of Inflammation. doi:10.1155/2018/3972104.
  45. ↑ Strassheim, Victoria Jane; Sunnquist, Madison; Jason, Leonard A.; Newton, Julia L. (September 1, 2018). "Defining the prevalence and symptom burden of those with self-reported severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a two-phase community pilot study in the North East of England". BMJ Open. 8 (9): e020775. doi:10.1136/bmjopen-2017-020775. ISSN 2044-6055. PMID 30232103.
  46. ↑ Venter, Marianne; Tomas, Cara; Pienaar, Ilse S.; Strassheim, Victoria; Erasmus, Elardus; Ng, Wan-Fai; Howell, Neil; Newton, Julia L.; Van der Westhuizen, Francois H. (December 2019). "MtDNA population variation in Myalgic encephalomyelitis/Chronic fatigue syndrome in two populations: a study of mildly deleterious variants". Scientific Reports. 9 (1). doi:10.1038/s41598-019-39060-1. ISSN 2045-2322. PMID 30814539.
  47. ↑ Robinson, Lucy J.; Gallagher, Peter; Watson, Stuart; Pearce, Ruth; Finkelmeyer, Andreas; Maclachlan, Laura; Newton, Julia L. (February 5, 2019). "Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction". PLOS ONE. 14 (2): e0210394. doi:10.1371/journal.pone.0210394. ISSN 1932-6203.
  48. ↑ Słomko, Joanna; Newton, Julia L; Kujawski, Sławomir; Tafil-Klawe, Małgorzata; Klawe, Jacek; Staines, Donald; Marshall-Gradisnik, Sonya; Zalewski, Pawel (March 2019). "Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study". BMJ Open. 9 (3): e023955. doi:10.1136/bmjopen-2018-023955. ISSN 2044-6055. PMID 30850404.
  49. ↑ Tomas, Cara; Brown, Audrey E.; Newton, Julia L.; Elson, Joanna L. (March 1, 2019). "Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types". PeerJ. 7: e6500. doi:10.7717/peerj.6500. ISSN 2167-8359. PMID 30847260.
  50. ↑ Strassheim, Victoria; Deary, Vincent; Webster, Deborah A.; Douglas, Jane; Newton, Julia L.; Hackett, Katie L. (July 9, 2019). "Conceptualizing the benefits of a group exercise program developed for those with chronic fatigue: a mixed methods clinical evaluation". Disability and Rehabilitation: 1–11. doi:10.1080/09638288.2019.1636315. ISSN 0963-8288.
  51. ↑ Morten, Karl J.; Newton, Julia L.; Joanna L. Elson; Potter, Michelle; Lodge, Tiffany A.; Tomas, Cara (August 7, 2019). "Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test". Scientific Reports. 9 (1): 1–9. doi:10.1038/s41598-019-47966-z. ISSN 2045-2322.
  52. ↑ Tomas, Cara; Elson, Joanna L.; Newton, Julia L.; Strassheim, Victoria; Walker, Mark (April 10, 2020). "The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function". PLoS ONE. 15 (4): e0231136. doi:10.1371/journal.pone.0231136.
  53. ↑ Tomas, Cara; Elson, Joanna L.; Newton, Julia L.; Walker, Mark (December 2020). "Substrate utilisation of cultured skeletal muscle cells in patients with CFS". Scientific Reports. 10 (1): 18232. doi:10.1038/s41598-020-75406-w. ISSN 2045-2322. PMC 7588462. PMID 33106563.
  54. ↑ Kujawski, Sławomir; Cossington, Jo; Słomko, Joanna; Dawes, Helen; Strong, James W.L.; Estevez-Lopez, Fernando; Murovska, Modra; Newton, Julia L.; Hodges, Lynette (October 26, 2020). "Prediction of Discontinuation of Structured Exercise Programme in Chronic Fatigue Syndrome Patients". Journal of Clinical Medicine. 9 (11): 3436. doi:10.3390/jcm9113436. ISSN 2077-0383. PMC 7693605. PMID 33114704.
  55. ↑ Kujawski, Sławomir; Cossington, Jo; Słomko, Joanna; Zawadka-Kunikowska, Monika; Tafil-Klawe, Małgorzata; Klawe, Jacek; Buszko, Katarzyna; Jakovljevic, Djordje; Kozakiewicz, Mariusz; Morten, Karl J.; Dawes, Helen; Strong, James W.L.; Murovska, Modra; Van Oosterwijck, Jessica; Estevez-Lopez, Fernando; Newton, Julia L.; Hodges, Lynette; Zalewski, Paweł; European Network on ME/CFS, (EUROMENE) (April 6, 2021). "Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients". Journal of Clinical Medicine. 10 (7): 1542. doi:10.3390/jcm10071542. ISSN 2077-0383.
  56. ↑ "Standing up for Fatigue - Professor Julia Newton and Professor Jason Ellis". Retrieved August 10, 2018.
  57. ↑ Invest in ME Research. "IIMEC3". Invest in ME Research. Retrieved August 10, 2018.
  58. ↑ Invest in ME Research. "IIMEC9 International ME Conference 2014". Invest in ME Research. Retrieved August 10, 2018.
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