Research studies of Nancy Klimas

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Nancy Klimas, MD, is a prolific researcher. A list of research studies related to chronic fatigue syndrome and fibromyalgia are listed below:

Studies prior to year 2000[edit | edit source]

  • 1994, Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression[1] - (Abstract)
  • 1995, Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew[2]
  • 1995, Relationships of Cognitive Difficulties to Immune Measures, Depression and Illness Burden in Chronic Fatigue Syndrome[3] - (Abstract)
  • 1996, Interindividual Immune Status Variation Patterns in Patients with [Chronic Fatigue Syndrome]]: Association with Gender and the Tumor Necrosis Factor System[4]
  • 1998, Pathogenesis of chronic fatigue syndrome and fibromyalgia - (No abstract available)[5]

2000[edit | edit source]

  • 2000, Comparative Analysis of Lymphocytes in Lymph Nodes and Peripheral Blood of Patients with Chronic Fatigue Syndrome[6] - (Abstract)
  • 2000, Chronic Fatigue Syndrome: Evidence Supporting the Hypothesis of a Behaviorally-Activated Neuromodulator of Fatigue[7]
  • 2000, Clinical and Immunologic Effects of Autologous Lymph Node Cell Transplant in Chronic Fatigue Syndrome[8] - (Abstract)
  • 2000, Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance[9]
  • 2000, Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance[10] - (Abstract)

2001[edit | edit source]

  • 2001, Cytokine and Other Immunologic Markers in Chronic Fatigue Syndrome and Their Relation to Neuropsychological Factors[11] - (Abstract)

2002[edit | edit source]

2003[edit | edit source]

2004[edit | edit source]

2005[edit | edit source]

2006[edit | edit source]

2007[edit | edit source]

2008[edit | edit source]

2009[edit | edit source]

2010[edit | edit source]

2011[edit | edit source]

2012[edit | edit source]

2013[edit | edit source]

  • 2013, A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome[28] - (Full text)
  • 2013, Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis[29] - (Abstract)
  • 2013, Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden[30] - (Full text)

2014[edit | edit source]

2015[edit | edit source]

  • 2015, Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome[34] - (Abstract)
  • 2015, Chronic fatigue syndrome and co-morbid and consequent conditions: evidence from a multi-site clinical epidemiology study[35] - (Abstract)
  • 2015, Distinct plasma immune signatures in ME/CFS are present early in the course of illness[36] - (Full text)
  • 2015, Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors[37] - (Full Text)
  • 2015, Using gene expression signatures to identify novel treatment strategies in gulf war illness[38] - (Full text)

2016[edit | edit source]

2017[edit | edit source]

2018[edit | edit source]

2019[edit | edit source]

  • 2019, From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story[51]
  • 2019, Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome[52] - (Abstract)
  • 2019, Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary[53] - (Abstract)
  • 2019, Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules[54] - (Abstract)
  • 2019, Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study[55] - (Abstract)
  • 2019, Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue[56] - (Abstract)

2020[edit | edit source]

  • 2020, Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS[57] - (Full text)
  • 2020, Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls[58] - (Full text)


See also[edit | edit source]

References[edit | edit source]

  1. Patarca, Roberto; Klimas, Nancy; Lugtendorf, S; Antoni, Michael H.; Fletcher, Mary Ann (1994), "Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression", Clinical Infectious Diseases, 18: S147-53, PMID 8148443
  2. Lutgendorf, SK; Antoni, MH; Ironson, G; Fletcher, MA; Penedo, F; Baum, A; Schneiderman, N; Klimas, N (1995). "Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew". Psychosomatic Medicine. 57 (4): 310-23. PMID 7480560.
  3. Lutgendorf, Susan; Klimas, Nancy; Antoni, Michael; Brickman, Andrew; Fletcher, Mary Ann (1995), "Relationships of Cognitive Difficulties to Immune Measures, Depression and Illness Burden in Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 1 (2): 23-41, doi:10.1300/J092v01n02_03
  4. Klimas, Nancy; Sandler, Dmitry; Garcia, Maria N.; Fletcher, Mary Ann (1996), "Interindividual Immune Status Variation Patterns in Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 2 (1): 13-39, doi:10.1300/J092v02n01_03
  5. Klimas, NG (1998), "Pathogenesis of chronic fatigue syndrome and fibromyalgia", Growth Hormone & IGF Research, 8 (Suppl B): 123-6, PMID 10990146
  6. Fletcher, Mary Ann; Maher, Kevin; Patarca-Montero, Roberto; Klimas, Nancy (2000), "Comparative Analysis of Lymphocytes in Lymph Nodes and Peripheral Blood of Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 7 (3): 65-75, doi:10.1300/J092v07n03_06
  7. Hurwitz, Barry E.; Brownley, Kimberly A.; Fletcher, Mary Ann; Klimas, Nancy G. (2000), "Chronic Fatigue Syndrome: Evidence Supporting the Hypothesis of a Behaviorally-Activated Neuromodulator of Fatigue", Journal of Chronic Fatigue Syndrome, 6 (1): 45-63, doi:10.1300/J092v06n02_06
  8. Klimas, Nancy; Patarca-Montero, Roberto; Maher, Kevin; Fletcher, Mary Ann (2000), "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance", Journal of Chronic Fatigue Syndrome, 8 (1): 39-55, doi:10.1300/J092v08n01_03
  9. Roberto Patarca Montero, Nancy G. Klimas & Mary Ann Fletcher. (2000). Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance. Journal of Chronic Fatigue Syndrome, Vol. 8, Iss. 1, pp. 3-37. http://dx.doi.org/10.1300/J092v08n01_02
  10. Montero, Roberto Patarca; Klimas, Nancy G.; Fletcher, Mary Ann (2000). "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance". Journal of Chronic Fatigue Syndrome. 8 (1): 3–37. doi:10.1300/J092v08n01_02.
  11. Patarca-Montero, Roberto; Antoni, Michael; Fletcher, Mary Ann; Klimas, Nancy G. (March 2001). "Cytokine and Other Immunologic Markers in Chronic Fatigue Syndrome and Their Relation to Neuropsychological Factors". Applied Neuropsychology. 8 (1): 51–64. doi:10.1207/S15324826AN0801_7. ISSN 0908-4282.
  12. Reeves, W.C.; Lloyd, A.; Vernon, S.D.; Klimas, N.; Jason, L.A.; Bleijenberg, G.; Evengard, B.; White, P.D.; Nisenbaum, R.; Unger, E. (2003), "Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution", BMC Health Services Research, 3 (25), doi:10.1186/1472-6963-3-25
  13. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02
  14. Glaser, R.; Padgett, D.A.; Litsky, M.L.; Baiocchi, R.A.; Yang, E.V.; Chen, M.; Yeh, P-E.; Klimas, N.G.; Marshall, G.D.; Whiteside, T.; Herberman, R.; Kiecolt-Glaser, J.K.; Williams, M.V. (2005), "Stress-associated changes in the steady state expression of latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer", Brain, Behavior and Immunity, 19 (2): 91-103, doi:10.1016/j.bbi.2004.09.001, PMID 15664781
  15. Klimas, NG; Koneru, AO (2007), "Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions", Current Rheumatology Reports, 9 (6): 482-7, PMID 18177602
  16. Jones, James F.; Kohl, Katrin S.; Ahmadipour, Nooshin; Bleijenberg, Gijs; Buchwald, Dedra; Evengard, Birgitta; Jason, Leonard A.; Klimas, Nancy G.; Lloyd, Andrew (August 2007). "Fatigue: Case definition and guidelines for collection, analysis, and presentation of immunization safety data". Vaccine. 25 (31): 5685–5696. doi:10.1016/j.vaccine.2007.02.065. ISSN 0264-410X.
  17. Fletcher, Mary Ann; Zeng, Xiao R; Barnes, Zachary; Levis, Silvina; Klimas, Nancy G (2009), "Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome", Journal of Translational Medicine, 7 (96), doi:10.1186/1479-5876-7-96
  18. Hurwitz BE, Coryell VT, Parker M, Martin P, Laperriere A, Klimas NG, Sfakianakis GN, Bilsker MS. Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function. Clinical Science (Lond). 2009 Oct 19;118(2):125-35. doi: 10.1042/CS20090055.
  19. Fletcher, Mary Ann; Rosenthal, Martin; Antoni, Michael; Ironson, Gail; Zeng, Xiao R; Barnes, Zachary; Harvey, Jeanna M; Hurwitz, Barry; Levis, Silvina; Broderick, Gordon; Klimas, Nancy G (2010), "Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome", Behavioral and Brain Functions, 6 (76), doi:10.1186/1744-9081-6-76
  20. Broderick, Gordon; Fuite, Jim; Kreitz, Andrea; Vernon, Suzanne; Klimas, Nancy; Fletcher, Mary Ann (2010), "A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome", Brain, Behavior, and Immunity, 24 (7): 1209–1217, doi:10.1016/j.bbi.2010.04.012
  21. Fletcher, M. A., Zeng, X. R., Maher, K., Levis, S., Hurwitz, B., Antoni, M., Broderick, G., Klimas, N. G. (2010). Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26. PLoS ONE, 5(5), e10817. http://doi.org/10.1371/journal.pone.0010817
  22. Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, A C P; Speight, N; Vallings, R; Bateman, L; Baumgarten-Austrheim, B; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Jo, D; Lewis, D; Light, A; Marshall-Gradisnik, S; Mena, I; Mikovits, JA; Miwa, K; Murovska, M; Pall, ML; Stevens, S (2011), "Myalgic encephalomyelitis: International Consensus Criteria.", Journal of Internal Medicine, 270 (4): 327-38, doi:10.1111/j.1365-2796.2011.02428.x, PMID 21777306
  23. Brenu, EW; van Driel, ML; Staines, DR; Ashton, KJ; Ramos, SB; Keane, J; Klimas, NG; Marshall-Gradisnik, SM (2011), "Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis", Journal of Translational Medicine, 9 (81), doi:10.1186/1479-5876-9-81
  24. Jason, LA; Unger, ER; Dimitrakoff, JD; Fagin, AP; Houghton, M; Cook, DB; Marshall, GD, Jr; Klimas, N; Snell, C (2012), "Minimum data elements for research reports on CFS", Brain, Behavior, Immunology, 26 (3): 401-6, doi:10.1016/j.bbi.2012.01.014, PMID 22306456
  25. Klimas, NG; Broderick, G; Fletcher, MA (2012), "Biomarkers for chronic fatigue", Brain, Behavior, and Immunity, 26 (8): 1202-10, doi:10.1016/j.bbi.2012.06.006, PMID 22732129
  26. Broderick, Gordon; Katz, Ben Z; Fernandes, Henrique; Fletcher, Mary Ann; Klimas, Nancy; Smith, Frederick A; O'Gorman, Maurice RG; Vernon, Suzanne D; Taylor, Renee (2012), "Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue", Journal of Translational Medicine, 10 (191), doi:10.1186/1479-5876-10-191
  27. Alter, Harvey J.; Mikovits, Judy A.; Switzer, William M.; Ruscetti, Francis W.; Lo, Shyh-Ching; Klimas, Nancy; Komaroff, Anthony L.; Montoya, Jose G.; Bateman, Lucinda; Levine, Susan; Peterson, Daniel; Levin, Bruce; Hanson, Maureen R.; Genfi, Afia; Bhat, Meera; Zheng, HaoQiang; Wang, Richard; Li, Bingjie; Hung, Guo-Chiuan; Lee, Li Ling; Sameroff, Stephen; Heneine, Walid; Coffin, John; Hornig, Mady; Lipkin, W. Ian (2012), "A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus", mBio, 3 (5): e00266–12, doi:10.1128/mBio.00266-12
  28. Smylie, Anne Liese; Broderick, Gordon; Fernandes, Henrique; Razdan, Shirin; Barnes, Zachary; Collado, Fanny; Sol, Connie; Fletcher, Mary Ann; Klimas, Nancy (June 25, 2013). "A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome". BMC Immunology. 14: 29. doi:10.1186/1471-2172-14-29. ISSN 1471-2172. PMC 3698072. PMID 23800166.
  29. Broderick, Gordon; Ben-Hamo, Rotem; Vashishtha, Saurabh; Efroni, Sol; Nathanson, Lubov; Barnes, Zachary; Fletcher, Mary Ann; Klimas, Nancy (February 1, 2013). "Altered immune pathway activity under exercise challenge in Gulf War Illness: An exploratory analysis". Brain, Behavior, and Immunity. 28: 159–169. doi:10.1016/j.bbi.2012.11.007. ISSN 0889-1591.
  30. Lattie, Emily G.; Antoni, Michael H.; Fletcher, Mary Ann; Czaja, Sara; Perdomo, Dolores; Sala, Andreina; Nair, Sankaran; Fu, Shih Hua; Penedo, Frank J. (2013). "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden". Fatigue : biomedicine, health & behavior. 1 (4). doi:10.1080/21641846.2013.843255. ISSN 2164-1846. PMC 3837381. PMID 24278791.
  31. Hall, DL; Lattie, EG; Antoni, MH; Fletcher, MA; Czaja, S; Perdomo, D; Klimas, NG (2014), "Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome", Psychoneuroendocrinology, 49: 26-31, doi:10.1016/j.psyneuen.2014.06.021, PMID 25049069
  32. Craddock, Travis J. A.; Fritsch, Paul; Rice, Jr, Mark A.; del Rosario, Ryan M.; Miller, Diane B.; Fletcher, Mary Ann; Klimas, Nancy G.; Broderick, Gordon (2014), "A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome", PLOS One, 9 (1): e84839, doi:10.1371/journal.pone.0084839
  33. Irlbeck, David M.; Vernon, Suzanne D.; McCleary, K. Kimberly; Bateman, Lucinda; Klimas, Nancy G.; Lapp, Charles W.; Peterson, Daniel L.; Brown, James R.; Remlinger, Katja S.; Wilfret, David A.; Gerondelis, Peter (2014). "No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank". BMC Research Notes. 7: 461. doi:10.1186/1756-0500-7-461.
  34. Klimas, N.G.; Ironson, G.; Carter, A.; Balbin, E.; Bateman, L.; Felsenstein, D.; Levine, S.; Peterson, D.; Chiu, K.; Allen, A.; Cunningham, K.; Gottschalk, C.G.; Fletcher, M; Hornig, M.; Canning, C.; Komaroff, A.L. (2015), "Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome", Fatigue: Biomedicine, Health & Behavior, 3 (2): 75-96, doi:10.1080/21641846.2015.1023652
  35. Bateman, L.; Darakjy, S.; Klimas, N.; Peterson, D.; Levine, S.M.; Allen, A.; Carlson, S.A.; Balbin, E.G.; Gottschalk, G.; March, D. (2015), "Chronic fatigue syndrome and co-morbid and consequent conditions: evidence from a multi-site clinical epidemiology study", Fatigue: Biomedicine, Health & Behavior, 3 (1): 1-15, doi:10.1080/21641846.2014.978109
  36. Hornig, M; Montoya, JG; Klimas, NG; Levine, SM; Felsenstein, D; Bateman, L; Peterson, DL; Gottschalk, CG; Schultz, AF; Che, X; Eddy, ML; Komaroff, AL; Lipkin, WI (2015). "Distinct plasma immune signatures in ME/CFS are present early in the course of illness". Science Advances. 1 (1). doi:10.1126/sciadv.1400121.
  37. Hall, DL; Antoni, MH; Lattie, EG; Jutagir, DR; Czaja, S; Perdomo, D; Lechner, SC; Stagl, JM; Bouchard, LC; Gudenkauf, LM; Traeger, L; Fletcher, MA; Klimas, NG (2015), "Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors", Fatigue: Biomedicine, Health & Behavior, 3 (3): 142-155, doi:10.1080/21641846.2015.1039289, PMID 26180660
  38. Craddock, Travis J.A.; Harvey, Jeanna M.; Nathanson, Lubov; Barnes, Zachary M.; Klimas, Nancy G.; Fletcher, Mary Ann; Broderick, Gordon (July 9, 2015). "Using gene expression signatures to identify novel treatment strategies in gulf war illness". BMC Medical Genomics. 8. doi:10.1186/s12920-015-0111-3. ISSN 1755-8794. PMC 4495687. PMID 26156520.
  39. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Ironson, Gail H.; Wohlgemuth, William; Vera Nunez, Maria; Garcia, Lina; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2016), "Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women", Journal of Neuroimmunology, 0 (0), doi:10.1016/j.jneuroim.2016.12.008
  40. Russell, Lindsey; Broderick, Gordon; Taylor, Renee; Fernandes, Henrique; Harvey, Jeanna; Barnes, Zachary; Smylie, AnneLiese; Collado, Fanny; Balbin, Elizabeth; Katz, Ben; Klimas, Nancy; Fletcher, Mary Ann (2016), "Illness progression in chronic fatigue syndrome: a shifting immune baseline", BMC Immunology, doi:10.1186/s12865-016-0142-3
  41. Harvey, Jeanna M.; Broderick, Gordon; Bowie, Alanna; Barnes, Zachary M.; Katz, Ben Z.; O’Gorman, Maurice R. G.; Vernon, Suzanne D.; Fletcher, Mary Ann; Klimas, Nancy G. (April 26, 2016). "Tracking post-infectious fatigue in clinic using routine Lab tests". BMC Pediatrics. 16. doi:10.1186/s12887-016-0596-8. ISSN 1471-2431. PMC 4847210. PMID 27118537.
  42. Barkin, JA; Czul, F; Barkin, JS; Klimas, NG; Rey, IR; Moshiree, B (2016), "Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis", Digestive Diseases and Sciences, 61 (8): 2344-50, doi:10.1007/s10620-016-4227-x, PMID 27344315
  43. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (2017), "Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model", Int J Psychophysiol, 0 (0), doi:10.1016/j.ijpsycho.2017.09.009
  44. Halpin, P; Williams, MV; Klimas, NG; Fletcher, MA; Barnes, Zachary; Ariza, ME (2017), "Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology", Journal of Medical Virology, doi:10.1002/jmv.24810, PMID 28303641
  45. Nagy-Szakal, Dorottya; Williams, Brent L.; Mishra, Nischay; Che, Xiaoyu; Lee, Bohyun; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Ramanan, Devi; Jain, Komal; Eddy, Meredith L.; Hornig, Mady; Lipkin, W. Ian (2017), "Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome", Microbiome, 5 (44), doi:10.1186/s40168-017-0261-y
  46. Unger, Elizabeth R.; Lin, Jin-Mann S.; Tian, Hao; Natelson, Benjamin H; Lange, Gudrun; Vu, Diana; Blate, Michelle; Klimas, Nancy G.; Balbin, Elizabeth G.; Bateman, Lucinda; Allen, Ali; Lapp, Charles W.; Springs, Wendy; Kogelnik, Andreas M.; Phan, Catrina C.; Danver, Joan; Podell, Richard N.; Fitzpatrick, Trisha; Peterson, Daniel L.; Gottschalk, C. Gunnar; Rajeevan, Mangalathu S.; MCAM Study Group (2017), "Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study.", American Journal of Epidemiology, 1–10, doi:10.1093/aje/kwx029
  47. Hall, DL; Lattie, EG; Milrad, SF; Czaja, S; Fletcher, MA; Klimas, N; Perdomo, D; Antoni, MH (2017), "Telephone-administered versus live group cognitive behavioral stress management for adults with CFS", J Psychosom Res, 93: 41-47, doi:10.1016/j.jpsychores.2016.12.004
  48. Montoya, Jose G; Anderson, Jill N; Adolphs, Danya L; Bateman, Lucinda; Klimas, Nancy; Levine, Susan M; Garvert, Donn W; Kaiser, Jon D (2018), "KPAX002 as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A prospective, randomized trial" (PDF), International Journal of Clinical and Experimental Medicine, 11 (3): 2890-2900
  49. Nagy-Szakal, Dorottya; Barupal, Dinesh K.; Lee, Bohyun; Che, Xiaoyu; Williams, Brent L.; Kahn, Ellie J. R.; Ukaigwe, Joy E.; Bateman, Lucinda; Klimas, Nancy G.; Komaroff, Anthony L.; Levine, Susan; Montoya, Jose G.; Peterson, Daniel L.; Levin, Bruce; Hornig, Mady; Fiehn, Oliver; Lipkin, W. Ian (2018), "Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics", Scientific Reports, 8 (1): 10056, doi:10.1038/s41598-018-28477-9
  50. Trivedi, Malav S.; Oltra, Elisa; Sarria, Leonor; Rose, Natasha; Beljanski, Vladimir; Fletcher, Mary Ann; Klimas, Nancy G.; Nathanson, Lubov (July 2018). "Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA methylation patterns". PlosOne. doi:10.1371/journal.pone.0201066.
  51. Klimas, N.G.; Fletcher, M.A.; Abreu, M.M.; Aenlle, K.; Craddock, T.; Broderick, G. (February 2019). "From biomarkers to targeted treatment: The myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and gulf war illness (GWI) story". Brain, Behavior, and Immunity. 76: e40. doi:10.1016/j.bbi.2018.11.301.
  52. Morris, Matthew C.; Cooney, Katherine E.; Sedghamiz, Hooman; Abreu, Maria; Collado, Fanny; Balbin, Elizabeth G.; Craddock, Travis J.A.; Klimas, Nancy G.; Broderick, Gordon; Fletcher, Mary Ann (March 2019). "Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.03.002.
  53. Richman, Spencer; Morris, Matthew C.; Broderick, Gordon; Craddock, Travis J.A.; Klimas, Nancy G.; Fletcher, Mary Ann (March 2019). "Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.02.011.
  54. Jeffrey, Mary G.; Nathanson, Lubov; Aenlle, Kristina; Barnes, Zachary M.; Baig, Mirza; Broderick, Gordon; Klimas, Nancy G.; Fletcher, Mary Ann; Craddock, Travis J.A. (March 2019). "Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules". Clinical Therapeutics. doi:10.1016/j.clinthera.2019.01.011.
  55. Perez, Melanie; Jaundoo, Rajeev; Hilton, Kelly; Del Alamo, Ana; Gemayel, Kristina; Klimas, Nancy G.; Craddock, Travis J.; Nathanson, Lubov (May 2019). "Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. doi:10.3389/fped.2019.00206.
  56. Milrad, Sara F.; Hall, Daniel L.; Jutagir, Devika R.; Lattie, Emily G.; Czaja, Sara J.; Perdomo, Dolores M.; Ironson, Gail; Doss, Brian D.; Mendez, Armando; Fletcher, Mary Ann; Klimas, Nancy; Antoni, Michael H. (July 2019). "Relationship satisfaction, communication self-efficacy, and chronic fatigue syndrome-related fatigue". Social Science & Medicine: 112392. doi:10.1016/j.socscimed.2019.112392.
  57. Cheema, Amanpreet K.; Sarria, Leonor; Bekheit, Mina; Collado, Fanny; Almenar‐Pérez, Eloy; Martín‐Martínez, Eva; Alegre, Jose; Castro‐Marrero, Jesus; Fletcher, Mary A.; Klimas, Nancy; Oltra, Elisa; Nathanson, Lubov (April 14, 2020). "Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS". Journal of Cellular and Molecular Medicine. 00: 1–13. doi:10.1111/jcmm.15260. ISSN 1582-4934. PMID 32291908.
  58. Abou-Donia, Mohamed B.; Lapadula, Elizabeth S.; Krengel, Maxine H.; Quinn, Emily; LeClair, Jessica; Massaro, Joseph; Conboy, Lisa A.; Kokkotou, Efi; Abreu, Maria (September 5, 2020). "Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls". Brain Sciences. 10 (9): 610. doi:10.3390/brainsci10090610. ISSN 2076-3425.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

neuroendocrine relating to hormones that influence the nervous system

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

etiology The cause of origin, especially of a disease.

autoantibody An antibody that works against the body's own antigens, a hallmark of autoimmune diseases. Autoantibodies are the opposite of an antibodies.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience. Although "Somatic Symptom Disorder" is the term used by DSM-5, the term "Bodily Distress Disorder" has been proposed for ICD-11. (Learn more: www.psychologytoday.com)

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.