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Gastroparesis is a neuro-muscular abnormality that causes delayed gastric emptying which, in turn, causes a premature full feeling while eating, bloating, nausea, acid reflux, regurgitation, belching, and occasional vomiting. It is a co-morbid condition associated with ME/CFS, Ehlers Danlos Syndrome, and several other diseases.[1][2]

Gastroparesis may be precipitated by a viral illness such as Epstein-Barr virus or a viral infection that causes gastroenteritis or the “stomach flu." Studies have implicated an immune dysfunction, as well as, a dysfunction of the autonomic nervous system as part of the pathophysiology. It can, also, result when the vagus nerve is damaged by illness or injury.[3] Seventy to eighty percent of individuals with primary gastroparesis are young women.[4]

There is no cure, at present, for gastroparesis, so the primary treatment is to manage symptoms with: pro-motility medications, acid-suppressing medications, antacids, and anti-nausea medications if needed. Diet, also, plays a large role in symptom control. In particular, avoid high fat and high fiber foods, eat small portions throughout the day, and use liquid food supplements.[5]

Gastroparesis is frequently misdiagnosed as Irritable Bowel Syndrome (IBS), but the chief difference is where the distress is occurring. Gastroparesis refers to a disorder in the upper digestion system, especially the stomach, whereas, IBS refers to the lower digestion system, especially the bowels. A series of tests may be necessary for determining if one has gastroparesis, including: endoscopy, CT scan, upper gastrointestinal (GI) series, breath test, and a Gastric emptying study.[6] The American Motility Society has established that a 4-hour “Gastric emptying test" is the standard for diagnosing gastroparesis.[7]

Studies[edit | edit source]

  • 2004, Gastric emptying is slow in chronic fatigue syndrome[8](Full Text)
  • 2016, Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis[9](Abstract)

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References[edit | edit source]

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

enterovirus - A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more:

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.