Michael Houghton, PhD, is a Professor at the Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada. He was the first to successfully identify and clone the Hepatitis C virus. His professional interests are the Hepatitis C virus, the Hepatitis B virus, and exploring if other chronic illnesses are caused or exacerbated by an acute or persistent viral infection.
Dr. Houghton and his virology team are working on a biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) using diagnostic cytokine patterns (specifically circulating interleukin (IL)-16, IL-7, and Vascular Endothelial Growth Factor A (VEGF-A). The team is also investigating if a novel pathogen is associated with a cluster of CFS patients.
Awards[edit | edit source]
- Canada Excellence Research Chair in Virology at the University of Alberta
- 2000, Albert Lasker Clinical Medical Research Award
Chronic Fatigue Syndrome Advisory Committee[edit | edit source]
Notable studies[edit | edit source]
- 2011, No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome(Full Text)
- 2012, Minimum data elements for research reports on CFS.(Full text)
- 2016, Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome(Full text)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Landi, Abdolamir; Broadhurst, David; Vernon, Suzanne D.; Tyrrell, D. Lorne J.; Houghton, Michael (Feb 2016). "Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome". Cytokine. 78: 27–36. doi:10.1016/j.cyto.2015.11.018.
- HHS.gov (2010), October 12 & 13, 2010 CFSAC Meeting (PDF) (Roster)
- Steffen, Imke; Tyrrell, D. Lorne; Stein, Eleanor; Montalvo, Leilani; Lee, Tzong-Hae; Zhou, Yanchen; Lu, Kai; Switzer, William M.; Tang, Shaohua; Jia, Hongwei; Hockman, Darren; Santer, Deanna M.; Logan, Michael; Landi, Amir; Law, John; Houghton, Michael; Simmons, Graham (Nov 17, 2011). "No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome". PLoS ONE. 6 (11): e27870. doi:10.1371/journal.pone.0027870. ISSN 1932-6203. PMC . PMID 22114717.
- Jason, LA; Unger, ER; Dimitrakoff, JD; Fagin, AP; Houghton, M; Cook, DB; Marshall, GD, Jr; Klimas, N; Snell, C (2012), "Minimum data elements for research reports on CFS", Brain, Behavior, Immunology, 26 (3): 401-6, doi:10.1016/j.bbi.2012.01.014, PMID 22306456
Chronic fatigue syndrome advisory committee (CFSAC) - (sometimes pronounced SIF-SACK) A US government advisory council that met twice per year, covering current topics related to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Meetings usually lasted for two days and the results were presented to the Secretary of Health and Human Services (HHS). After 15 years, on September 5, 2018, CFSAC's charter was not renewed by the Department of HHS, effectively dissolving the committee without notice or warning.
Antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.