Vascular endothelial growth factor

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Vascular Endothelial Growth Factor (VEGF) or Vascular Endothelial Growth Factor A (VEGF-A) is a signal protein produced by cells that stimulates blood vessel formation (vasculogenesis and angiogenesis).[1] Vascular Endothelial Growth Factor was originally known as vascular permeability factor (VPF).

The VEGF family help maintain blood vessel and lymphatic systems.[1]

ME/CFS[edit | edit source]

Landi et al. (2016) found lower levels of VEGF, IL-7 and IL-16 in 100 long-term ME/CFS patients compared to controls but studies by Horning et al. (2015) and Montoya et al. (2017) did not find this statistically significant.[2][3]

Notable studies[edit | edit source]

  • 2016, Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Maniscalco, W. M.; D’Angio, C.T. (January 1, 2006). Laurent, Geoffrey J.; Shapiro (eds.). VASCULAR ENDOTHELIAL GROWTH FACTOR. Oxford: Academic Press. pp. 413–418. ISBN 978-0-12-370879-3. Unknown parameter |editor2- first= ignored (help)
  2. Landi, Abdolamir; Broadhurst, David; Vernon, Suzanne D.; Tyrrell, D. Lorne J.; Houghton, Michael (February 2016). "Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome". Cytokine. 78: 27–36. doi:10.1016/j.cyto.2015.11.018. ISSN 1096-0023. PMID 26615570.
  3. Giloteaux, Ludovic; O'Neal, Adam; Castro-Marrero, Jesús; Levine, Susan M.; Hanson, Maureen R. (October 12, 2020). "Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study". Journal of Translational Medicine. 18 (1): 387. doi:10.1186/s12967-020-02560-0. ISSN 1479-5876.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.