M. Ronald Glaser, Ph.D, (d. April 3, 2019) was a professor in the Department of Cancer Biology and Genetics and Director of the Institute for Behavioral Medicine Research at the College of Medicine, The Ohio State University, Columbus, Ohio. His main research interests were tumor virology/stress and immunology.
Dr. Glaser advocated that a possible subset of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) could be from viral reactivation following a stressful event. In 2012, Dr Glaser and his team announced work on a possible diagnostic biomarker for CFS that involves the detection of EBV-encoded DNA polymerase and EBV-encoded dUTPase, two proteins that are produced early in the process of Epstein-Barr virus reactivation.
Chronic Fatigue Syndrome Advisory Committee[edit | edit source]
2001 CDC Case Definition Workshop[edit | edit source]
In 2001, the CDC held a three-day workshop on Issues Related to the Chronic Fatigue Syndrome (CFS) Research Case Definition. Dr Glaser was one of the invited participants. During the workshop, Dr Glaser gave the presentation: "Immune Modulation by Latent Herpesvirus Proteins."
Notable studies[edit | edit source]
- 1986, Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity.
- 1998, Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome.
- 2005, Stress-associated changes in the steady state expression of latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer
- 2012, Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset(Full Text)
Talks and interviews[edit | edit source]
Online presence[edit | edit source]
Learn more[edit | edit source]
- 2013, "Dr. Ronald Glaser - Chronic Fatigue Syndrome and the Pathophysiology of EBV Infection " by Cort Johnson
- 2019, Obituary
See also[edit | edit source]
References[edit | edit source]
- "Ronald Glaser - View Obituary & Service Information". Ronald Glaser Obituary. Retrieved April 6, 2019.
- HHS.gov (2009), May 27 & 28, 2009 CFSAC Meeting (PDF) (Roster)
- HHS.gov (2010), October 12 & 13, 2010 CFSAC Meeting (PDF) (Roster)
- Glaser, Ronald; Rice, John; Speicher, Carl E.; Stout, Julie C.; Kiecolt-Glaser, Janice K. (October 1986), "Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity.", Behavioral Neuroscience, 100 (5): 675-678, doi:10.1037/0735-7044.100.5.675
- Glaser, R; Kiecolt-Glaser, JK (1998), "Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome.", The American Journal of Medicine, 105: 35S-42S, PMID 9790480
- Glaser, R.; Padgett, D.A.; Litsky, M.L.; Baiocchi, R.A.; Yang, E.V.; Chen, M.; Yeh, P-E.; Klimas, N.G.; Marshall, G.D.; Whiteside, T.; Herberman, R.; Kiecolt-Glaser, J.K.; Williams, M.V. (2005), "Stress-associated changes in the steady state expression of latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer", Brain, Behavior and Immunity, 19 (2): 91-103, doi:10.1016/j.bbi.2004.09.001, PMID 15664781
- Lerner, AM; Ariza, ME; Williams, M; Jason, L; Beqaj, S; Fitzgerald, JT; Lemeshow, S; Glaser, R (2012), "Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset", PLoS ONE, 7 (11): e47891, doi:10.1371/journal.pone.0047891
Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.
stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.