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Citations needed, cleanup needed, notable studies (2018)
Common co-morbid diagnoses[edit | edit source]
The following are known or thought to be frequently co-morbid with and possibly related to ME
- Postural orthostatic tachychardia (POTS)
- Ehler's Danlos Syndromes
- Mast cell activation disorder
- Irritable bowel syndrome
Other immune and neuro-immune diseases[edit | edit source]
There are several conditions that are not known to be comorbid with ME but where our understanding of the underlying pathophysiology might inform approaches to researching all immune diseases, or where treatments may have applications across diagnosis.
- Common variable immunodeficiency (CVID)
- Idiopathic intracranial hypertension
- Multiple sclerosis
- Lyme disease
- Female predominant diseases
Common missed or misdiagnoses[edit | edit source]
- Ehler's Danlos Syndromes (EDS)
- Chronic Lyme disease
- Mast cell activation syndrome (MCAS)
- Mitochondrial myopathy
- Postural Orthostatic Tachycardia Syndrome (POTS)
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- NICE (2017). "NICE CG53 guidance evidence | Appendix C - stakeholder consultation comments table". www.nice.org.uk. Retrieved Dec 6, 2018.
- Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.