The plasma membranes of cells contain combinations of glycosphingolipids and protein receptors organized in glycolipoprotein microdomains termed lipid rafts. Lipid rafts are disbursed through the cell membrane and play important roles in protein and lipid transport, as well as cell signaling.
A study of patients with postural orthostatic tachycardia syndrome for autoimmunoreactive IgGs to lipid raft proteins in the heart. Patients with chronic fatigue syndrome were found to have decreased sphingolipids and glycosphingolipids, building blocks of lipid rafts.
Learn more[edit | edit source]
- Naviaux's metabolism paper is about as big as you think, #MEAction, August 30th 2016
- Metabolic features of chronic fatigue syndrome, Robert Naviaux Study
- III 6 1 Lipid Rafts - youtube
- Membranes Ch. 2 Lipid Rafts - youtube
- Cholesterol, lipid rafts, and disease - The Journal of Clinical Investigaiton
See also[edit | edit source]
References[edit | edit source]
- "Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with postural orthostatic tachycardia syndrome". Translational Research. 162 (1): 34–44. Jul 1, 2013. doi:10.1016/j.trsl.2013.03.002. ISSN 1931-5244.
- Naviaux, Robert K.; Naviaux, Jane C.; Li, Kefeng; Bright, A. Taylor; Alaynick, William A.; Wang, Lin; Baxter, Asha; Nathan, Neil; Anderson, Wayne (Sep 13, 2016). "Metabolic features of chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 113 (37): E5472–E5480. doi:10.1073/pnas.1607571113. ISSN 0027-8424. PMID 27573827.